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"If you're not having fun, you're not learning. There's a pleasure in finding things out."

-Richard Feynman

Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social

Encoding the glucose identity by discrete hypothalamic neurons via the gut-brain axis A specific neuronal population in the brain encoding D-glucose, the brain’s main fuel, has been proposed but not yet identified. Kim et al. discovered a circuit involving CRFPVN neurons, fasting-activ...

Encoding the glucose identity by discrete hypothalamic neurons via the gut-brain axis www.cell.com/neuron/fullt...

Representation of sex-specific social memory in ventral CA1 neurons Recognizing familiar individuals is crucial for adaptive social interactions among animals. However, the multidimensional nature of social memory encompassing sexual information remains unelucidated. ...

Representation of sex-specific social memory in ventral CA1 neurons
www.science.org/doi/10.1126/...

Prefrontal cortex development and its implications in mental illness - Neuropsychopharmacology Neuropsychopharmacology - Prefrontal cortex development and its implications in mental illness

Prefrontal cortex development and its implications in mental illness
www.nature.com/articles/s41...

Precision psychiatry roadmap: towards a biology-informed framework for mental disorders - Molecular Psychiatry Molecular Psychiatry - Precision psychiatry roadmap: towards a biology-informed framework for mental disorders

Precision psychiatry roadmap: towards a biology-informed framework for mental disorders www.nature.com/articles/s41...

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

The do’s and don’ts of scientific image editing
www.nature.com/articles/d41...

Early childhood behavioral inhibition predicts altered social and emotional functioning in early adulthood: An ecological momentary assessment study.
psycnet.apa.org/record/2025-...

The brain works at more than 10 bits per second
www.nature.com/articles/s41...

A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Smelling food primes your brain for satiety.
www.nature.com/articles/s42...

Not just neurons: The diverse cellular landscape of learning and memory Research on learning and memory has primarily focused on neurons. This perspective argues that understanding the biology of memory demands a comprehensive approach that encompasses not only neurons bu...

Not just neurons: The diverse cellular landscape of learning and memory
www.cell.com/neuron/fullt...

Sí, ya lo vi.

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy Rodriguez et al. investigate the impact of biased signaling with a dual GLP-1R/GIPR agonist. Biased GLP-1R and GIPR agonism leads to better and prolonged glucose lowering, greater food intake reductio...

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

www.cell.com/cell-reports...

Conserved brain-wide emergence of emotional response from sensory experience in humans and mice Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discovera...

Conserved brain-wide emergence of emotional response from sensory experience in humans and mice

www.science.org/doi/10.1126/...

Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults www.cambridge.org/core/journal...

Anxiety, fear, panic: An approach to assessing the defensive behavior system across the predatory imminence continuum - Learning & Behavior In order to effectively thwart predation, antipredator defensive behaviors must be matched to the current spatio-temporal relationship to the predator. We have proposed a model where different defensi...

Anxiety, fear, panic: An approach to assessing the defensive behavior system across the predatory imminence continuum

link.springer.com/article/10.3...

Emerging roles of astrocytes as immune effectors in the central nervous system The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocyte...

Emerging roles of astrocytes as immune effectors in the central nervous system

www.cell.com/trends/immun...

The structure of human sweetness A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods. Single-particle cryo-EM reve...

The structure of human sweetness

www.cell.com/cell/fulltex...

The neurobiology of irritable bowel syndrome - Molecular Psychiatry Molecular Psychiatry - The neurobiology of irritable bowel syndrome

The neurobiology of irritable bowel syndrome
www.nature.com/articles/s41...

What clinicians should know about the contribution of modern behavioral genetics to psychiatric problems
www.cambridge.org/core/journal...

Soft touch quells loneliness in mice Touch modulates one of two dueling types of hypothalamic neurons that, thermostat-like, balance an animal’s drive for social interaction.

Soft touch quells loneliness in mice

www.thetransmitter.org/social-behav...

Social belonging: brain structure and function is linked to membership in sports teams, religious groups, and social clubs Abstract. Human behavior across the life span is driven by the psychological need to belong, right from kindergarten to bingo nights. Being part of social

Social belonging: brain structure and function is linked to membership in sports teams, religious groups, and social clubs
academic.oup.com/cercor/artic...

Mapping Lesions That Cause Psychosis This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target

jamanetwork.com/journals/jam...

Individual, intergroup and nation-level influences on belief in conspiracy theories - Nature Reviews Psychology Conspiracy theories have the potential to undermine governments, promote racism, ignite extremism and threaten public health efforts. In this Review, Hornsey et al. synthesize the literature on factor...

Individual, intergroup and nation-level influences on belief in conspiracy theories

go.nature.com/3VoNjiv

Mobile phone dependence is associated with a reduction in brain gray matter volume. // La adicción al celular está asociada con una reducción en la materia gris del cerebro.

The neuroimmune connectome in health and disease
www.nature.com/articles/s41...

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Let us know what's on your mind & what we should be writing about.

Your brain is full of microplastics: are they harming you?
www.nature.com/articles/d41...

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution Pękowska and colleagues model primate astrocyte evolution in the dish and find that human cells are bigger and more complex than their chimpanzee and macaque counterparts. Human astrocytes activate lo...

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution

www.cell.com/cell-stem-ce...