Christy Gliniak

Fantastic work by the Dixit lab at Yale sheds light on how amino acid metabolism directly influences adipose tissue function and browning @natrevendo.nature.com #metabolism #obesityresearch rdcu.be/etksL

Adipose tissue ageing: implications for metabolic health and lifespan Nature Reviews Endocrinology, Published online: 23 June 2025; doi:10.1038/s41574-025-01142-8This Review outlines changes in endocrine and metabolic function that occur in various adipose tissue depots during ageing and explains how these alterations contribute to age-related decline in metabolic health. The Review also discusses how various treatments might slow this decline by improving adipose tissue function.

New content online: Adipose tissue ageing: implications for metabolic health and lifespan

Unpicking the effects of FGF21 on longevity Nature Reviews Endocrinology - Unpicking the effects of FGF21 on longevity

Unpicking the effects of FGF21 on longevity - Thanks to Claire Greenhill @natrevendo.nature.com for this apt research highlight on our FGF21 longevity paper! @utswdiabetes @cp-cellmetabolism.bsky.social #metabolism #FGF21 rdcu.be/etg69

FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression This study demonstrates that inducible, adipocyte-specific overexpression of FGF21 in adult male mice improves metabolic health and extends lifespan during high-fat diet feeding. These benefits occur independently of growth suppression and are associated with reduced visceral adipose inflammation and ceramide levels, offering mechanistic insights into FGF21’s pro-longevity effects under metabolic stress.

Online now: FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression

Thank you to Philipp Scherer, friends, and colleagues who contributed over the years to this interesting aging story!! FGF21-based therapeutics have incredible potential for many chronic diseases.

GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

RESEARCH | L Townsend, G Steinberg et. al. (@mcmasteruniversity.bsky.social‬)

Anxiety-like behaviour in mice, under stress, is mediated by GDF15 release in response to adipose lipolysis.

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

Nature research paper: Unravelling cysteine-deficiency-associated rapid weight loss

https://go.nature.com/4mpetns

Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

In mice cysteine-restriction-induced adipose browning and #weightloss requires sympathetic nervous system-derived noradrenaline signalling via β3-adrenergic-receptors that is independent of FGF21 and UCP1 @naturemetabolism.bsky.social
www.nature.com/articles/s42...