Ahmed Eltanahy

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems Multi-Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential end....

🧠 A new era for brain #organoids! Researchers have created Multi-Region Brain Organoids that model human brain development more accurately by integrating cerebral, mid-hindbrain & endothelial regions.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

#neuroskyence #devbio 🧪

Uridine Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

a great not-to-miss piece from the @lyssiotislab.bsky.social

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

Online now: A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Norepinephrine signals through astrocytes to modulate synapses | Science www.science.org/doi/10.1126/...

Eltanahy et al. (University of Nevada) used Mightex’s #PolygonDMD Illuminator to reveal how violet light (405 nm) regulates ocular fluid balance via calcium signaling and choroid pressure dynamics. Precision light control in action!
👉 Read more here: www.mightexbio.com/light-sensit...

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour - Nature A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

www.nature.com/articles/s41...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...

Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY

Niche-specific therapeutic targeting of myeloid cells in the central nervous system In this review, Prinz and Frosch describe how the central nervous system is partitioned into distinct immune niches, each hosting unique myeloid cell populations that shape disease outcomes. They highlight novel cellular and molecular strategies to modulate these populations in a compartment-specific manner and discuss the challenges in translating these approaches from animal models to clinical practice.

Online now: Niche-specific therapeutic targeting of myeloid cells in the central nervous system

A neuroimmune circuit mediates cancer cachexia-associated apathy Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system - Nature Cell Biology Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...

Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma.

Wonder if these NSCs exist in humans & can show similar therapeutic potential

www.nature.com/articles/s41...

NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection - Nature Metabolism Krapić, Kavazović and colleagues dissect the mechanism by which natural killer cells drive adipose tissue remodelling during viral infection, thus fuelling antiviral immune responses.

And here is the link to the original research paper from Krapić, et al: www.nature.com/articles/s42...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics www.nature.com/articles/s42...

Thanks Dr. Earley. Much appreciated.

Me too please. Thanks 😊

Thanks Dr. Mullins for your interest.

Thank you @haoyin.bsky.social ... much appreciated 😊

Happy to share my paper at PNAS!
#Choriocapillaris is intrinsically sensitive to light, endowed with #Opsins, a mechanism that we show is necessary for ocular physiology and the mysterious #choroid. t.co/TcxDuuS30O