Daniela Senft

Ageing and Cancer Ageing is a fundamental driver of cancer, fostering the accumulation of genetic and epigenetic changes that disrupt cellular homeostasis, promote immune ...

Check out our focused collection of articles highlighting research on ageing and cancer to better cancer prevention, diagnostics and therapy.
www.nature.com/collections/...

It features #Comments #Reviews #Perspectives from leaders in the field: a 🧵

How does ageing affect cancer? Read all about it in our latest Focus isse ⬇️

The impact of sex on metastasis - Nature Reviews Cancer Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate for mechanistic and quantitative studies for the future development of sex-tailored therapies.

As part of our Series on #SexDifferences in cancer, Yingsheng Zhang & Xue Li wrote a Comment article that outlines the impact of #sex on #metastasis. Check it out ⬇️

Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity - Nature Reviews Cancer Neurotoxicity impacting the central and peripheral nervous systems is a considerable adverse effect of both conventional and novel cancer therapies. In this Review, Karschnia et al. outline what is currently known about the mechanisms that underlie the clinical symptoms of central nervous system injury and peripheral neuropathy and the ongoing development of interventions to treat and prevent this unmet medical need.

Review🚨

Karschnia, Nelson & Dietrich outline what is currently known about the mechanisms that underlie the clinical symptoms of cancer therapy-related central nervous system injury and peripheral neuropathy

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Our SEPTEMBER issue is live! 🌤️🍂🌻🍂

It features articles on:
- ER stress responses in anti-cancer immunity
- Regulatory T cells in the TME
- Metabolic adaptations of brain metastasis
- Engineering strategies for nanoparticles

Read it now👇
bit.ly/4mW1JnQ

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.

We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky

www.nature.com/articles/d41...

Gender and sex interactions are intrinsic components of cancer phenotypes - Nature Reviews Cancer In this Perspective, Joshua Rubin emphasizes the importance of gender–sex interaction (GSI) differences in cancer biology and clinical parameters to enhance precision medicine. He outlines the challenges and opportunities of integrating GSI effects into personalized oncology and argues that optimal outcomes require extending our current molecular approaches to include family history, life history and individual vulnerabilities in our diverse groups of patients with cancer.

🚨 PERSEPCTIVE 🚨

Here Joshua Rubin emphasizes the challenges, opportunities and importance of integrating gender-sex interaction differences into cancer biology & clinical parameters to enhance precision medicine. @uwsom-wwami.bsky.social‬

👇 📖 for more details

Congratulations!!!

Jordan Lee describes the Tumor Molecular Pathology (TMP) machine learning toolkit that can classify new samples into previously defined #TCGA molecular subtypes
@ohsunews.bsky.social
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Metabolic interplays between the tumour and the host shape the tumour macroenvironment - Nature Reviews Cancer In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...

At the #KSTumorMetab25 meeting?

Check out the latest review by Ayelet Erez & colleagues for more details on how metabolic interplay between the tumour & the host shape the tumour macroenvironment.

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bit.ly/3ReWTEo

#REVIEW🚨

Velculescu & Team review targeted and genome-wide #cfDNA detection approaches and discuss their potential to complement existing screening programs or enhance early cancer detection for those cancers without effective screening methods.

Review

#ResearchHighlight 🚨
‪@claballabio.bsky.social‬ from Leanne Li group @crick.ac.uk show that #neuroendocrine #SCLC cells exhibit electrical activity that drives tumour progression. They rely on OXPHOS to meet the high energy demand of these electrophysiological processes. 👀⬇️

Women’s health Research into women’s health has suffered from historical neglect and lack of funding.

To mark #InternationalWomensDay tomorrow, the #NatureReviews Collection on women's health has been updated. Click below to read articles on various aspects of women's health, including brand new Reviews from @natrevcardiol.bsky.social and @natrevgastrohep.bsky.social go.nature.com/30kDWG3

#REVIEW🚨

In this Expert Recommendation, @drholowatyj.bsky.social &Co cover the current state of the field in #AppendicealCancer and propose a conceptual research framework to advance knowledge of this rare cancer to deliver better outcomes for patients.
#RareDiseaseDay @acpmpresearch.bsky.social
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Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer - Nature Reviews Cancer

Triantafyllos Stylianopoulos, Rakesh K. Jain & Co review the utility of continuous models & discrete models in therapy delivery and efficacy in cancer and propose ways to integrate mechanistic and AI-based models to improve patient outcomes.
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bit.ly/3X7JGAu

Re-envisioning genetic predisposition to childhood and adolescent cancers - Nature Reviews Cancer Genetic predisposition is the major known cause of cancer in children and adolescents. In this Review, Kratz highlights the genetic architecture of cancer in children and adolescents, examining cancer predisposition syndromes, cancer predisposition genes, embryonic mosaicism and polygenic risk...

#REVIEW 🚨

Genetic predisposition is the major known cause of cancer in children. In our Feb issue, Kratz highlights the genetic architecture of it, focusing on its roles in cancer prediction, prevention, surveillance and therapy.

📖 👇
https://bit.ly/3ZHhZ...

Chromothripsis in cancer - Nature Reviews Cancer

# REVIEW 🚨
Simovic-Lorenz & Ernst from @dkfz.bsky.social discuss mechanisms of #chromothripsis, its impact on cancer and vulnerabilities of chromothriptic tumours.
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Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities - Nature Reviews Cancer

Beyond prostate cancer: Androgen receptor signaling plays a key role in multiple malignancies. Dotto & collegues explore AR’s context-dependent functions in cancer cells & the TME, and highlight AR-targeting cancer trials.
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Why do patients with cancer die? - Nature Reviews Cancer In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a....

FINALLY 🥁...our top most downloaded article of the year is…. 🥁🥁🥁

Why do patients with cancer die? By @tcox.bsky.social, Erik Sahai, et al.

https://bit.ly/3WIyl...

#metastasis #cancertherapy #cancermodels

@crick.ac.uk @natureportfolio.bsky.social #NRCtop10of2024

Cancer therapy with antibodies - Nature Reviews Cancer In this Review, Paul et al. provide an overview of therapeutic antibodies as an important modality in cancer therapy today. They summarize the different approaches used by antibodies to target cancer cells including those of immune checkpoint inhibitors, bispecific antibodies...

🥳 Our 2nd most downloaded article in 2024:

Cancer therapy with antibodies by Paul, Gabelli, Ho, van Elsas et al.

https://bit.ly/3EjrG...

#drugdevelopment #cancertherapy #antibodytherapy

@natureportfolio.bsky.social #NRCtop10of2024

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic factors induce the epigenetic changes necessary for tumorigenesis.

🥳 Our 4th most downloaded article in 2024:

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues

https://bit.ly/42Cvr...

@rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024

A guide to artificial intelligence for cancer researchers - Nature Reviews Cancer This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery...

🥳 Our 3rd most downloaded article in 2024:

A guide to artificial intelligence for cancer researchers by @jnkt.bsky.social and colleagues

https://bit.ly/3yEzl...

#AI #artificialintelligence #cancermodelling

@natureportfolio.bsky.social #NRCtop10of2024

#REVIEW 🚨

Miriam Merad & Co ‪@sinaiimmuno.bsky.social‬
outline the molecular basis of #DendriticCell maturation and the mechanisms through which cancer impairs #DC maturation and consider the potential for DC-focused cancer #immunotherapeutics.
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Allies in the epidermis - Nature Reviews Cancer Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin.

#RESEARCHHIGHLIGHT

Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, in @cp-cancercell.bsky.social, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin.

Read the highlight here 👇
https://bit.ly/4jL8W...

Maximizing the dual benefit of pet dogs in cancer trials - Nature Reviews Cancer Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.

#COMMENT 🐶 🐱

Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz & Atherton highlight successes and emphasize the need for broader application to improve human cancer treatments.

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https://bit.ly/414hi...

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment - Nature Reviews Cancer In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They highlight opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.

🥳 Our 5th most downloaded article in 2024:

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang

https://bit.ly/4jAOu...

@stanfordpress.bsky.social @stanfordmedicine.bsky.social @natureportfolio.bsky.social #NRCtop10of2024

The evolutionary theory of cancer: challenges and potential solutions - Nature Reviews Cancer Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some non-evolutionary phenomena in cancer cannot be captured by the theory.

🥳 Our 6th most downloaded article in 2024:

The evolutionary theory of cancer: challenges and potential solutions by @lucielaplane.bsky.social & @cmaley.bsky.social

https://bit.ly/3PWjS...

#cancermodels #evolutionarybiology

@sorbonne-universite.fr @natureportfolio.bsky.social #NRCtop10of2024

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities - Nature Reviews Cancer Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies...

🥳 Our 7th most downloaded article in 2024:

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities by Bardelli, Russo et. al
https://bit.ly/3CkSE...

#persistercells #DTPs #cancerresistance

@natureportfolio.bsky.social #NRCtop10of2024

Exploiting temporal aspects of cancer immunotherapy - Nature Reviews Cancer The tumour immune microenvironment greatly affects responses to immune checkpoint therapies. In this Perspective, Zemek et al. explore the dynamic changes in response to both immunotherapy and conventional treatment and advocate for strategic combination therapies over time....

🥳 Our 8th most downloaded article in 2024:

Exploiting temporal aspects of cancer immunotherapy by Lesterhuis et al.
https://bit.ly/3Xs8l...

#immunotherapy

@natureportfolio.bsky.social #NRCtop10of2024

Tertiary lymphoid structures in anticancer immunity - Nature Reviews Cancer Transient ectopic lymphoid structures known as tertiary lymphoid structures (TLS) have been observed in many solid tumour types. Teillaud et al. discuss how these TLS potentially orchestrate immune responses against tumours locally...

🥳 Our 9th most downloaded article in 2024:

Tertiary lymphoid structures in anticancer immunity by Dieu-Nosjean et al.
https://bit.ly/3WGcv...

#cancermicroenvironment

@inserm.fr @natureportfolio.bsky.social #NRCtop10of2024