@markhermanmd.bsky.social
Dad, scientist, physician, other. Endocrine Chief, Houston, TX. All views and opinions are my own.
Characterised members of the human SLC25 mitochondrial family. Members of the mitochondrial carriers are shown in rainbow (blue to red) cartoon and surface representations with their primary substrates shown in sphere representations to scale. Only one paralogue is shown.
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
25.07.2025 11:29 — 👍 29 🔁 9 💬 0 📌 0An underrated form of social media is European travel bloggers coming inexplicably to Houston and then attempting to walk across 12 lane highways only to discover that there are no sidewalks or any other ways to get to any destination on foot once you get outside the city center.
22.07.2025 15:00 — 👍 1254 🔁 120 💬 51 📌 31
New #DiabetesBio
Featuring!
1. Adipose fibrosis
2. GCKR & PNPLA3 in liver metabolism
3. Spotlight on Dr. Barbara Kahn (2025 Renold Award)
🎙️Libsyn: shorturl.at/DPEs3
▶️ YouTube: shorturl.at/K40c1
🎧 Spotify: shorturl.at/slyKl
🍏 Apple Podcasts: shorturl.at/wT3j0
A figure showing the changes from baseline in systolic blood pressure (SBP), plasma aldosterone–renin ratio (ARR), and serum potassium level for each patient.
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
#gastrosky #medsky #immunology
02.07.2025 19:21 — 👍 20 🔁 5 💬 0 📌 0
Understanding the predictors of metabolic dysfunction-associated steatotic liver disease—
ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M
Great nod to the photography work of Bernd and Hilla Becher
22.06.2025 07:19 — 👍 100 🔁 16 💬 2 📌 0
In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results: nej.md/4ngEZ36 #ADASciSessions
21.06.2025 13:05 — 👍 14 🔁 8 💬 1 📌 1
Thousands gather at Houston City Hall for No Kings protest as nationwide movement takes center stage www.houstonchronicle.com/news/houston...
14.06.2025 15:57 — 👍 2 🔁 0 💬 0 📌 0
If you are a researcher whose federal funding has been terminated, the Spencer Foundation is offering rapid response grants to close the gaps. Application deadline is June 13:
(h/t to @agu.org's Planetary Sciences Section newsletter for the info!)
www.spencer.org/research-gra...
A map of the contiguous 48 states titled: Thirty National Weather Service offices are without a chief meteorologist Some of these offices issue forecasts for major population centers such as New York City, Houston and Cleveland. Several are prone to hurricanes and tornadoes. Callouts include: Upton, NY - Covers New York City and southern Connecticut Tampa, FL - Hard hit by Hurricane Milton in 2024 Houston, TX - All management positions vacant Paducah/Louisville/Jackson, KY - Nearly the whole state of Kentucky is covered by forecast areas without leadership
Donald Trump and Elon Musk have left Houston, Tampa, New York and other major cities without head meteorologists just ahead of what will be another busy hurricane season
This is straight-up life-threatening malpractice
(h/t @lisamjarvis.bsky.social )
www.cnn.com/2025/05/02/w...
Powerhouse episode of #DiabetesBio is out!
Catch up w/ #MikeRickels of #DiabetesCareOnAir, hear from 2025 Banting Medalist #SteveKahn, and get the scoop from #ADA Sessions Chair #MarkAtkinson.
Plus, 75 years of NIDDK shorturl.at/uUOjv
YT shorturl.at/Q3cE6
🍎 shorturl.at/Mrz3L
🎧 shorturl.at/iExmL
impact update: apparently, a couple of Houston bakeries/dessert shops are DMing each other about the crazy prices they're seeing after reading this. It's a more widespread problem than we think!
28.04.2025 22:12 — 👍 4 🔁 4 💬 0 📌 0
NIDDK is celebrating its 75th anniversary this year by releasing a collection of articles highlighting the advances made. I am happy that I could contribute to one on advances in cell replacement therapy. Check it out! diabetesjournals.org/diabetes/art...
24.04.2025 18:16 — 👍 7 🔁 1 💬 1 📌 0
The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene".
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
8 Resources to study Transcription factor binding, enhancers and histone modification distribution
1. ENCODE www.encodeproject.org/
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
16.04.2025 21:00 — 👍 2662 🔁 612 💬 145 📌 129
Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org !
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
Now HERE'S an interesting study.
Gets at a burning diet q: Can macronutrient ratios affect energy expenditure?
Til now, the answer from research has been "yes, but only a little."
Here's a study where *decreasing* protein ups energy expenditure a whopping 20%.
www.nature.com/articles/s42...
And now back to our regularly scheduled "Data and Concern" segment...
05.03.2025 12:46 — 👍 45 🔁 18 💬 1 📌 4Nothing new has posted for CSR, but I read a rumor (can't find the source) that new posts might start tomorrow
03.03.2025 20:22 — 👍 2 🔁 0 💬 1 📌 0What are good #biomarkers of #aging? Exciting data on plasma proteomics, epigenetic clocks and other molecular parameters might supplement existing biomarkers of health, morbidity and mortality in the future. However, at the moment, good clinical data from large and heterogeneous...
1/3
Extending my grant update this morning. Here are data limited to new and competitive renewal applications.
The Pause is dead, Long live the Pause...
Confirmed (by many sources) news about 50 NIH Study Sections being allowed to announce meetings in the Federal Register.
As usual, MANY more questions than answers...
1/2
My son's life was saved by medical research. Trump wants to slash it. | Opinion
www.houstonchronicle.com/opinion/lett...
The switch to virtual is just to prevent people from traveling. Unless it is in the register it will still be cancelled the day before or the day of. This has been a consistent pattern.
26.02.2025 14:03 — 👍 7 🔁 0 💬 1 📌 0
Some good-ish news from NIH
“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”
As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
The NIH continues to be fully halted. 11/11 study sections canceled today, which includes the study section my grant was meant to be reviewed at. This is never ending and so damaging.
www.csr.nih.gov/RevPanelsAnd...
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
24.02.2025 16:17 — 👍 371 🔁 293 💬 45 📌 23
