Faraz Mardakheh

Super happy to announce that our science magazine initiative is now on #BlueSky.
Follow @stemdoradoscimag.bsky.social for magazine life updates, release dates, kids contests, events we will attend to and more. All about making learning science and technology fun, inspiring and memorable for kids!

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

📣 New preprint 📣

We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.

Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications Gene regulation in oocytes relies heavily on poly(A) tail-length changes. Here, the authors develop PAL-AI, a neural network model that predicts tail-length changes, identifies regulatory motifs, and ...

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

This is a genuinely huge opportunity for the right person.

We @dunnschool.bsky.social are proud not only of our discovery science to transform human health, but also of the support we offer early career fellows.

Join us, and launch your independent career!

Please share.

Exciting times!!🎉🍾

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

Woohoo! So psyched to see this awesome work from the Jovanovic lab out in the world! Congrats to all the authors on this tour-de-force!

www.cell.com/cell/fulltex...

An outstanding opportunity - a great Institute in a beautiful city

Optogenetic storage and release of protein and mRNA in live cells and animals - Nature Communications Spatiotemporal control of biomolecules is a key challenge in cell biology. Here, authors introduce RELISR, an optogenetic condensate system enabling reversible, light-dependent sequestration and relea...

Optogenetic storage and release of protein and mRNA in live cells and animals | Nature Communications share.google/gz8nYXZ3hUVh...

#spatialbiology #imagingtools #fluorescencemicroscopy

#RNAsky

Thinking about who's hanging out with you RNA in cells? Here's a super overview of the (many!) things you can do to find out. Many thanks @mardakheh.bsky.social @shechnerlab.bsky.social #RNA #RNAinteractome

It was a lot of fun writing this review with the amazing @shechnerlab.bsky.social! If you are looking for a review of the new RNA-centric methods to study RNA interactions, then look no more!

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
👉 deadline 20/06
👇 check it out

www.godinholab.com

Check out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇

Are you interested in doing a masters in RNA biology? We are accepting students for 2-years masters by research degree (1 year research, 1 year write up). Only 1 year tuition fees (£25k international, £5k home) fees include bench fees normally worth £4k. @biouea.bsky.social www.theakaylab.com

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute Add brief description here

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

Ribonuclease activity undermines immune sensing of naked extracellular RNA Castellano et al. show that when extracellular RNases are inhibited or absent, naked extracellular RNA is internalized spontaneously by cells, inducing inflammation mediated by endosomal TLRs or cytos...

Check out our paper about naked extracellular RNAs uptake, TLR signaling, endosomal escape, and the role of RNases in regulating this process.

www.cell.com/cell-genomic...

New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...

#RNAsky

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

👇👇👇Don’t miss this 👇👇👇

One of my favourite meetings! Registration deadline is 1st of June! Don't miss it!

www.yourlocalguardian.co.uk/news/2517797...

Don’t miss this 👇

Sequence-based prediction of intermolecular interactions driven by disordered regions Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

www.science.org/doi/10.1126/...

This is a fantastic paper, with huge implications for the study of DNA and binding proteins.Also, by combining this side by side to XRNAX, XDNAX might become the best way of addressing the challenging question of dual RNA/DNA binding proteins
Huge congratulations to all involved!🎉🎉🎉
#ChromatinSky

Join us for an in-person mini-symposium at @qmbci.bsky.social on July 16th to discuss several topics at the intersection of RNA biology and cancer. Free to come. Pizza and drinks to network @diunguyenvnuk.bsky.social @kevinrouault.bsky.social @rnasociety.bsky.social 👇👇

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

Repeat-element RNAs integrate a neuronal growth circuit SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...