Sandra O. Tomé

Don’t miss the LATE PIA activities this week at #AAIC2025:

🧠 PIA Day session: July 26, 10:15-11:15am

🗒️ PIA Day Resource Fair: July 26, 12:30-2:30pm

🖇️ Intermission session for networking: July 30, 12:15-2pm (room 808)

🩺 LATE Clinical Toolbox: July 30, 2-3:30pm (Hall F)

Alzheimer's disease and its co‐pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of APOE ε4 INTRODUCTION In neurodegenerative dementias, the co-occurrence and interaction of amyloid β peptide (Aβ), tau pathology, and other pathological lesions confound their individual contributions to neu.....

Check out our latest paper👇 Here, we explored the impact of different neuropathologies and APOEe4 on hippocampal degeneration 📉🧠🔬. Very proud of @gawor-neuro.bsky.social for leading this study!

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

You can now join our new LATE PIA! 🧠

istaart.alz.org/groups/home/87

With this PIA, we want to raise awareness of this dementia-driving pathology, foster collaborations, and ultimately improve TDP-43 targeting therapies.
Stay tuned!
#dementia

Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies - Acta Neuropathologica Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describe brains with LATE-NC but lacking intermediate or severe levels of Alzheimer’s...

This new study sought to characterize pure #LATE-NC using data from 32 ADRCs. Importantly, it suggests that pure LATE-NC occurs in about 5% of the elderly population, and is usually associated with #dementia. 🧠🔬

link.springer.com/article/10.1...