Chen Wang

Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity The cryo-EM structure of the retron Eco8 system reveals an autoinhibited 4:4:4 complex of RT, msDNA, and OLD nuclease. Phage SSB binding to msdDNA unleashes non-specific nuclease activity to restrict phage replication, establishing msDNA as a molecular switch for Eco8 activation.

Online Now: Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity Online now:

30.10.2025 19:14 — 👍 3    🔁 1    💬 0    📌 0

Thank you, Kotaro!

30.10.2025 23:08 — 👍 0    🔁 0    💬 0    📌 0

Molecular mechanism of Eco8-mediated anti-phage defense Yuan et al. uncover how the bacterial defense system Eco8 detects and combats phage infection. Through structural and biochemical analyses, they show that phage ssDNA-binding proteins trigger Eco8 act...

There’s another Retron Eco8 paper published in Molecular Cell today: Molecular mechanism of Eco8-mediated anti-phage defense: Molecular Cell www.cell.com/molecular-ce...

30.10.2025 15:08 — 👍 1    🔁 0    💬 0    📌 0

Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity The cryo-EM structure of the retron Eco8 system reveals an autoinhibited 4:4:4 complex of RT, msDNA, and OLD nuclease. Phage SSB binding to msdDNA unleashes non-specific nuclease activity to restrict ...

I’m thrilled to share our Retron Eco8 paper published in Molecular Cell today. Thanks all Fu lab members and our collaborators.
👉Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. www.cell.com/molecular-ce...

30.10.2025 15:06 — 👍 10    🔁 6    💬 2    📌 0

😥

17.07.2025 01:47 — 👍 0    🔁 0    💬 0    📌 0

Structural insights into type I and type II Lamassu anti-phage systems https://www.biorxiv.org/content/10.1101/2025.06.23.660979v1

24.06.2025 03:17 — 👍 3    🔁 4    💬 0    📌 0

Thrilled to share our new paper uncovering the defense mechanism of Retron-Septu antiphage systems! Grateful to the incredible Fu lab team, our outstanding colleagues at UMass Chan and OSU, and wonderful collaborators at UCSD for their support and contributions.

16.06.2025 14:41 — 👍 1    🔁 0    💬 0    📌 0

❄️🔬🧬🦠🧫 Disassembly activates Retron-Septu for antiphage defense | Science www.science.org/doi/10.1126/... @rti-umasschan.bsky.social #RNA #DNA #retrons #microbiology #phage #immunity #phagesky #MicroSky

16.06.2025 05:31 — 👍 26    🔁 4    💬 0    📌 1

Disassembly activates Retron-Septu for antiphage defense - PubMed Retrons are antiphage defense systems that produce multicopy single-stranded DNA (msDNA) and hold promises for genome engineering. However, the mechanisms of defense remain unclear. The Retron-Septu system...

Hot off the press from the RTI: Disassembly activates Retron-Septu for antiphage defense
pubmed.ncbi.nlm.nih.gov/40504952/?ut... #RNA #RNATherapeutics

13.06.2025 17:02 — 👍 2    🔁 3    💬 0    📌 0

🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9

02.05.2025 21:02 — 👍 70    🔁 29    💬 2    📌 0

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence - Nature Nature - A DNA-gated molecular guard controls bacterial Hailong anti-phage defence

Excited to share my PhD work in the Kranzusch Lab published in @nature.com!

Two key discoveries:
- Nucleotides can act as negative regulators of antiviral immunity
- Ion channel activation is gated by DNA

Thank you to our all collaborators! @soreklab.bsky.social

www.nature.com/articles/s41...

30.04.2025 18:57 — 👍 62    🔁 17    💬 2    📌 1

Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage

Joint work with the Tamulaitienė and Kranzusch labs

www.nature.com/articles/s41...

Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!

30.04.2025 18:44 — 👍 88    🔁 43    💬 2    📌 1

Yale Postdoctoral Positions | Office for Postdoctoral Affairs

My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdoc...

22.04.2025 17:00 — 👍 1    🔁 1    💬 0    📌 0

So excited to see a Fu Lab trainee take the stage at #ASBMB25! Great to see our lab represented.

13.04.2025 15:46 — 👍 2    🔁 1    💬 0    📌 0

Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery https://www.biorxiv.org/content/10.1101/2025.04.02.646746v1

02.04.2025 16:16 — 👍 4    🔁 5    💬 0    📌 0

Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase Bacteria defend themselves from viral predation using diverse immune systems, many of which sense and target foreign DNA for degradation. Defense-associated reverse transcriptase (DRT) systems provide...

Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...

26.03.2025 22:13 — 👍 63    🔁 35    💬 3    📌 2