Dr. Utkarsh Bhardwaj

Hidden networks in the brain Dendritic nanotubes extend brain connectivity beyond synapses

In Science, researchers report the observation of dendritic nanotubes in brain tissue from mice and humans. The discovery suggests that the current understanding of the brain’s organization may be incomplete, overlooking a hidden layer of connectivity. #SciencePerspective https://scim.ag/470Cdr4

Our Brain—Immune Axis Gets A Jolt Facts, data and analytics about biomedical matters

A rundown on the big advances we’re seeing on the brain-immune axis

erictopol.substack.com/p/our-braini...

Congratulations Kathrin!

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...

Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes

Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate that targets the ce...

#WeekendRead! #LiveForever! Ji &co show @cp-cellmetabolism.bsky.social that stem cell derived exomes contain a miRA capable of block cell cycle inhibitors, allowing the proliferation of senescent cells & rejuvenating mice extending life span & physical performances! www.cell.com/cell-metabol...

Endothelial cells as key players in cerebral small vessel disease - Nature Reviews Neuroscience Cerebral small vessel disease is a common cause of dementia and stroke. In this Perspective, Wardlaw and co-workers describe evidence from human brain imaging and preclinical models that points to dys...

🚨 Timely and interesting review on brain endothelial cells doi.org/10.1038/s415... #cerebrovascular

Adaptations of neutrophils in cancer There is a renewed interest in neutrophil biology, largely instigated by their prominence in cancer. From an immunologist’s perspective, a conceptual …

#MustRead for #Neutrophils & #TumorImmunology lovers! @cp-immunity.bsky.social by @MelissaNg @DanielaCerezo-Wallis @LaiGuanNg & @andreshidalgo.bsky.social! www.sciencedirect.com/science/arti...

Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections | mBio The unfolded protein response (UPR) is a cellular stress response pathway activated by the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER) (1). The UPR aims to restore...

ER stress in cells (cell-autonomous) can be transmitted to neighbouring unstressed cells to generate a broader systemic ER stress response (cell non-autonomous ER stress) and hence have a wider impact in an organism where the stress was initially induced. Its significance to virus infections! 👇🏽

It feels like everyone has a stomach bug. A new norovirus strain might be to blame, CDC data suggests Lower immunity to the new GII.17 strain could be leading to more infections.

www.cbsnews.com/news/new-nor...

#AMentorIsForever 💎🔬🧪🧬🧫

Wow! Congratulations to whole team 😊 amazing work (My weekend read) 😁

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Wow!!

Overwintering of Usutu virus in mosquitoes, The Netherlands - Parasites & Vectors Analyses of mosquito-borne virus outbreaks have revealed the presence of similar virus strains over several years. However, it remains unclear how mosquito-borne viruses can persist over winter, when ...

Another paper from a great collaboration in the OneHealthPACT consortium link.springer.com/article/10.1...