Simon Beggs

Decreased KCC2 expression in the human spinal dorsal horn... : PAIN date there is no evidence supporting or opposing this hypothesis in humans. Here, we demonstrate that KCC2 expression is decreased in superficial dorsal horn neurons of organ donors who died with a do...

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Happy birthday Brenda Milner! 🧠🎉
Today is her 107th birthday, she's a legend, a superhero.

“It wasn’t like a man, it was like some damned juggernaut”

This is *exactly* what today needed. I am, as ever, in your debt. Cheers!

Very sorry to read this, Stephani. Wishing you all the best for whatever’s next.

How about using Ancho Reyes instead of vodka? Why am I asking? Will report back!

This is fantastic! The lime really elevates it, can't imagine going back to an El Presidente after this, although I should probably make one now, just to be sure...

And the office of Pain Policy and Planning was eliminated. That office has coordinated pain research across NIH for ages and played a key role in many important initiatives.

Elbows out and Bottoms Up! Cheers!

Sometimes the answer is an absinthe fountain. Saturday night at The Parlour with @skochlab.bsky.social working out what the question is.

Yes it’s three penguin kites on a beach in Le Touquet, what of it?

The world is your oyster, quite literally here in Le Touquet in Normandy. I do enjoy a challenge…

A much needed escape to the bucolic Kent countryside for some vintage motorcycle racing. The roar of ancient machines and the perfume of Castrol R in the air. Delicious!

Just thinking about how much time I spend applying for grants and how this dumb shit is gonna spend 20 million or something on this dumb nonsense and will publish it in cureus next to Vinay Prasads latest paper “why Arnold ventures should be allowed to buy people and execute them for sport”

Congratulations Greg!

🧠🐭📊🔬🧬BIG PREPRINT UPDATES:

Mimicking opioid analgesia in cortical pain circuits

We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with our synthetic opioid gene therapy

www.biorxiv.org/content/10.1...

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Meningeal regulatory T cells inhibit nociception in female mice T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (Treg cells) could inhibit nocic...

Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...

I may be tired and a little hoarse, but as I said again and again on the Senate floor, this is a moment where we cannot afford to be silent, when we must speak up.

I think that may have been the previous one. I remember hearing about the hurricane. I was a humble masters student then (mid 90s) so stories of exotic conferences were all second-hand.

Miami was my first, 99? Wading through three telephone directories circling posters, arranging to meet at the notice boards (with 15000 other people). The smell of Spraymount in the departure lounge.

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

Michael Gold, founding president of USASP, explains why industry can’t fill the gap in funding from cuts to NIH in letter to the editor of local paper (Pittsburgh Post Gazette)

Will you be joining us in the 5 minute music dance experience, Mr Rechavi?

It’s that time of the day

Happy St Patrick's Day! I shall be bathing in Guinness later, hopefully.

sorry, what?

Halle-bloody-lujah!

An opportunty to jump at!

The Bordeaux Summer on pain circuits. Five days of talks and hands-on workshops of cutting edge techniques. A few places still available, deadline is the 31st of March. Its an amazing opportunity not to be missed!
bss-neuropain.u-bordeaux.fr/en/