Check out our preprint for details! We also look at the development of layer 6 corticothalamic neuron dendrites, which differ from axons in both time course and activity dependence, the maturation of PV interneuron physiology and connectivity, and more (end)
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Synaptogenesis is selective for parvalbumin interneurons within layer 6, and in translaminar connections to layer 4. This is despite these interneurons being far less abundant than neighboring excitatory neurons in both layers (6/7)
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Example traces of patch clamp recordings of layer 6 corticothalamic neurons with parvalbumin interneurons, or with other layer 6 corticothalamic neurons, at P7 and at P15.
Do excitatory neurons selectively innervate their targets from the beginning, or make synapses promiscuously and then eliminate the off-target ones? We find that layer 6 corticothalamic neurons selectively form functional synapses to parvalbumin interneurons (5/7)
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Example reconstructions of a control and a Kir2.1-expressing layer 6 corticothalamic neuron, showing increased axonal arborization in the Kir2.1-expressing cell
How does developmental neuronal activity affect axon arbor growth? We found that hyperpolarizing layer 6 corticothalamic neurons increased axon arbor elaboration specifically in layer 6, but not in layers 4 or 5 (4/7)
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When and how do layer 6 corticothalamic neurons elaborate their intracortical axon branches? Using sparse labeling and lightsheet imaging we found two stages of outgrowth separated by a period of stasis in the first two postnatal weeks (3/7)
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We focused on layer 6 corticothalamic neurons, which have a striking preference for connections to inhibitory interneurons that express parvalbumin over other excitatory cell types. In mice, this synaptic preference for inhibitory neurons can regulate cortical responses to sensory input (2/7)
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NINDS K99 Fellow in the Zuchero lab @ Stanford | myelin cell biology | Former Helen Hay Whitney | PhD in the Walter lab
@UCSF | she/her
Glasshalfemptologist.
https://drugmonkey.wordpress.com/
science & health @ The Atlantic
Inserm research director at Institut NeuroMyoGène in Lyon, France
Interested in cerebral cortex development, kinases and all things mitochondria
Post-doc in the Zuchero and Soltesz labs, Stanford Neurosurgery, studying neuron-oligodendrocyte interactions. Previously PhD in the Kolodkin lab @HopkinsNeuro
Professor of Neuroscience. Studying neural development, regeneration, and control of innate behaviors at Johns Hopkins.
@sethblackshaw at Twitter.
Neuroscientist of sorts. Head of the Kebschull Lab at Johns Hopkins BME. https://www.kebschull-lab.org/
Director, Translational Neuroscience at Lieber Institute and Professor, Johns Hopkins School of Medicine studying molecular regulation across species in circuits impacted in complex brain disorders. Native plants/flowers/wetland habitats. Own opinions.
Neuroscientist, Associate Professor at JHU, Memory tagging and reconstitution, Circuit assembly, Synaptic connectivity, Cognitive Learning, Tool development
Hopkins | Kavli NDI
Temporal Decision Making, Neural representations of time, timing, and time evolving value
https://sites.google.com/site/marshallshuler/
Kurt Golcuk, Elissa Sutlief, Charlie Walters, Rebekah Zhang, Shichen Zhang, Ziyi Guo, Jiayi Chen
The Johns Hopkins OneNeuro Initiative is building a university-wide neuroscience community to understand the brain - from molecules to mind.
Hacker, Computational Neuroscience, ML beyond logistic regression, bear and muscle spindle aficionado. Passionate about open source. #deeplabcut and see https://mathislab.org for more.
Neuroscience Professor at Harvard University. Personal account and posts here. Research group website: https://vnmurthylab.org.
Assistant professor at Tufts University studying molecular mechanisms of synapse function. Views my own. https://www.bygravelab.com
🇨🇦 neuroscientist, postdoc at UCSF · NINDS K99 fellow · oligodendrocytes & myelin | synapses & circuits · PhD Johns Hopkins/NIDA, BSc UofT · she/her
www.oligodendrocyte.org
Official Bluesky account of The Kavli Foundation.
Advancing science for the benefit of humanity.🔬
kavlifoundation.org
Advancing the frontiers of basic science through grantmaking, research and public engagement. Sign up for our newsletter: simonsfoundation.org/newsletter
Postdoc in the Calipari Lab at Vanderbilt University
🇩🇪 neuroscientist, postdoc in Ding lab @Stanford · NINDS K99 fellow · motor circuits | synaptic plasticity | in vivo imaging · BS TU München, PhD Johns Hopkins · he/him
sites.google.com/view/richard-roth/
