Caleb Lareau

🖨️ Hot off the press 🍾 :
I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version:

rdcu.be/e4Lg8

Wellcome Connecting Science Single Cell Biology hybrid conference Conference dates: 10-12 June 2026 Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online. Bursary deadline: 16 March 2026 Abstract deadline: 30 March 2026 In person registration deadline: 11 May 2026 Virtual registration deadline: 1 June 2026 Image of a conference delegate presenting a scientific poster.

Registration for Single Cell Biology 2026 is now open! #SingleCell26

Join us as we explore new single cell research insights and discoveries beyond the traditional model organisms🧬

🗓️ 10-12 June
📍 Wellcome Genome Campus, UK
Bursaries available

📎 bit.ly/4pyTK21
#SingleCell #Spatial #Genomics

Excited to share my first preprint on federated conditional analysis of rare single variant and aggregate association tests across six genetically-inferred ancestry groups in All of Us and UK Biobank doi.org/10.64898/202...

Preprint from @lpachter.bsky.social lab argues journals should treat results as machine-readable objects, not just PDFs. Narratives stay for humans, but claims, evidence, and evaluations should ship in structured form so machines can index and verify. www.biorxiv.org/content/10.6... 1/ 🧵

I feel like vegemite jokes are an untapped market wdyt @psmibert.bsky.social

Thanks for the enthusiastic support and charting the path 🙏

Re-analysis of human population-scale whole genome seq data elucidates genetic architecture of EBV DNA persistence, a framework for the broader human virome
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...

This was a fun and rewarding collaboration! A great example of extracting biological signal from data hiding in plain sight

Scraps of viral DNA in biobank samples reveal secrets of Epstein–Barr virus Viral DNA that is usually dismissed when sequencing the human genome could help to uncover useful information about complex diseases.

There is also a wonderful summary of our work (including some important limitations) from Kristen Wade & Jill Hollenbach www.nature.com/articles/d41...

Scientists Inch Closer to Solving the ‘Kissing Disease’ Mystery Scientists have identified 22 genes that increase the risk of conditions like lupus, stroke, and rheumatoid arthritis in patients who’ve caught the virus behind mono, an illness known as the “kissing ...

EBV infection is a major detriment to human health. @ryandhindsa.bsky.social, Slavé, and I discussed the impact of this work with @bloomberg.com and some future outlooks

www.bloomberg.com/news/article...

What's been particularly gratifying about this study is the corroboration by independent groups that have arrived at complementary conclusions. Those preprints are here:

www.medrxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

www.medrxiv.org/content/10.6...

Our prior thread digesting this work is available here. The key findings are the same from the preprint, but there's a boatload of new analyses for corroboration and interpretation of this new biomarker.

bsky.app/profile/cale...

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.

Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social

www.nature.com/articles/s41...

Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA   Join the Cancer Signaling & Microenvironment Pro... Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA   Join the Cancer Signaling & Microenvironment Program at ...

The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.

More info here:
www.linkedin.com/feed/update/...

Questions: DM/Email me.

i see this all the time with no mention of structural suppression:

- Electoral College winner-take-all
- working day elections
- voter registration burden

turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.

We've summarized a detailed thread on this work over on X/Twitter (x.com/CalebLareau/...).

As newcomers to this protein design field, we’d very much welcome thoughts, feedback, missing citations, or ideas on how to steer this work next!

We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—

Fred's Team Support cancer research at Memorial Sloan Kettering Cancer Center.

If you are able, please consider donating to our team’s effort. 100% of your donations support riot work for a cure! secure2.convio.net/mskcc/site/T...

I had an unbelievable first time running the NYC Marathon with
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!

Typical day in lab honestly

The squad 🍌🍌🍌

We have some BIG PLANS TONIGHT!!!
with @ronanchaligne.bsky.social @mskcancercenter.bsky.social

Memorial Sloan Kettering Cancer Center Physician-Scientist Elected to the Prestigious National Academy of Medicine Omar Abdel-Wahab, MD, Chair of the Molecular Pharmacology Program at Sloan Kettering Institute (SKI); Evnin Family Chair in Molecular Pharmacology and Attending Physician on the Leukemia Service at Me...

We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu.

With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.

Congratulations, Dr. Abdel-Wahab!

bit.ly/49ezKw0

Zero arrests. 100,000 people. No violence. This who we are.

#nokings #nyc #weareallthefrog

Penn, U. of Southern California Reject Trump Compact The universities follow the Massachusetts Institute of Technology and Brown University in rejecting the Trump administration’s proposal that would require sweeping changes.

Penn and USC have also rejected the Compact!

That makes 4 - stronger together.

www.insidehighered.com/news/faculty...

The data is from April but holy moly

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians!

The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.