Dhiraj Indana

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...

This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.

I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...

Excited to contribute to the pioneering work at @damonrunyon.org @hhmi.org @elowitzlab.bsky.social!

How Do Embryos Know How Fast to Develop? In mammals, intracellular clocks begin to tick within days of fertilization.

Nice and clear summary of our work on animal species-specific developmental time in The Scientist
www.the-scientist.com/just-curious...

Amidst these troubling times, I have some positive personal news to share: I will be joining @imbavienna.bsky.social as a new group leader this fall! 🎉 I am excited for fun projects, surprising discoveries, and great discussions within the fantastic science community @vbcscitraining.bsky.social

My first project in the @elowitzlab.bsky.social is finally out in @cellpress.bsky.social! We explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓

doi.org/10.1016/j.ce...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

While our bodies seem static, our cells are constantly changing shape or on the move during tissue homeostasis or wound repair & even more dramatically during embryonic development, during events like gastrulation. Defining how cellular machines mediate these events is a key task for our field 1/n