The Kueh lab

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

Identification of proliferating neural progenitors in the adult human hippocampus Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

KuehLab on X: "Our latest preprint, on T cell receptor (TCR) signaling by condensate nucleation! This theory + experiment study was led by the brilliant Will White, with Jay Groves @UCB_Chemistry and David Baker @UWproteindesign and @Arielbs100.  (1/n) https://t.co/JGLukouM44" / X Our latest preprint, on T cell receptor (TCR) signaling by condensate nucleation! This theory + experiment study was led by the brilliant Will White, with Jay Groves @UCB_Chemistry and David Baker @UWproteindesign and @Arielbs100.  (1/n) https://t.co/JGLukouM44

For a summary, check out: x.com/Kueh_Lab/sta... (apologies, but this is on the old platform)

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social

www.pnas.org/doi/10.1073/...

First Phase 2 randomized trial of engineered T cells for a solid tumor—GI cancer— with some encouraging results
www.thelancet.com/journals/lan... @thelancet.com

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Congratulations Joe and Endi!

Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.

(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.

Q: How do we get ultra-high-res 3D genome maps?

A: New deep learning model, Cleopatra.

Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

Congratulations @anshulkundaje.bsky.social and co-workers! I'm partial to the composite TF motifs in thymic/immune development but this is a fantastic resource for many fields!

Check out this great resource of single cell multiome data, cell annotations, regulatory DNA models of cell type resolved chromatin accessibility & comprehensive annotation of motifs & sequence syntax for multiple tissues in early human development 1/

1. For the past thirty years I've had the best job in the world.


I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Trump promised scientific breakthroughs. Researchers say he’s breaking science. NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

Powerful new Washington Post story up...

wapo.st/426d9fT

(Gift link)

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NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

It’s the economy stupid- “There is no better investment than one that saves lives, supports local economies and drives America’s global leadership in biomedical innovation” www.forbes.com/sites/michae...

Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...

Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Me too. See you all there!!

I'm going to Stand Up for Science 2025 in Seattle. Seattle friends, come join! Fri March 7. Mural Amphitheatre at Seattle Center. 305 Harrison Street, Seattle. 12-3pm PST.

Rubio terminated 5800 USAID contracts – more than 90% of its foreign aid programs – in defiance of the courts.

Here’s a list of just some of the lifesaving awards that were terminated. Nearly all were Congressionally mandated. They’ve saved millions of lives. 🧵

This is a powerful (and accurate) speech both about curiosity driven research and about which institutions would be most hurt by a 15% cap on indirect cost rates (smaller academic med centers) and who would benefit (China).

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Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science."
"The weeks ahead may be the greatest test that the US scientific community has ever faced"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....

the word irony is written on a white background ALT: the word irony is written on a white background

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.

This helps me remember what this is all about.

Ironically, it is about the treatment of pain.

NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.

Mass firings decimate U.S. science agencies White House dismissals and rationale challenged by dismissed scientists and lawsuits

More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.

Opinion | Kennedy’s Anti-Vaccine Views Don’t Represent America (Gift Article) Threatening vaccine access is not only bad science, it’s bad politics.

I have a NYT essay out this morning. There is very little that Americans can agree on these days. Not religion, not sports, and certainly not politics. But there is one thing nearly everyone agrees on: Vaccines are good. (Gift link) www.nytimes.com/2025/02/16/o...

a poster that says if life gives you lemon make lemonade on it ALT: a poster that says if life gives you lemon make lemonade on it

ATTENTION (PLEASE SHARE)

If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.

There are lots of talented and accomplished people who may be looking for new opportunities.

Checking in with sources this morning...

The total from NIH was apparently slightly more than 1500 people (out of 5200 HHS Department-wide)

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Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...