Jo Carpenter

Congratulations Andy! Looks great 🩷

Thrilled to share that our work is now published in Science! ✨

We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭

www.science.org/doi/10.1126/...

🧵1/

“If everything is everywhere, why have distinct areas? Here we show that the function of a brain area is more related to how different types of information are combined (formatted) in neural representations than merely whether that information is present.”

Direct entorhinal control of CA1 temporal coding Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠

rdcu.be/evWtz

Congratulations Dan!!! 🩷✨

Fragmented replay of very large environments in the hippocampus of bats Hippocampal replays in bats flying in a 200-m tunnel depict short fragments of long flight trajectories, suggesting constraints on the mechanisms and functions of replay.

Amazing study: @tamir-eliav.bsky.social from the Ulanovsky lab describes replay events in a large scale environment (200 m tunnel). 🦇

www.cell.com/cell/abstrac...

(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.

Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...

Global modules robustly emerge from local interactions and smooth gradients - Nature The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.

1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social .
Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇

Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.

handsome boy 💖

Congratulations Abe and Rich!!

We are still taking applications!

Hippocampal neuronal activity is aligned with action plans - Nature Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.

It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.”
Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals

www.nature.com/articles/s41...

Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…

Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...

celebrating another year of excellent science, happy animals, and *happy people* at the kavli ❤️✨

@kavlintnu.bsky.social

YouTube video by nature video Do octopuses dream? Brain recordings provide the first clues

Do octopuses dream?
In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible.
youtu.be/006DjAixu9E?...

Let’s go!!!!!! Well deserved 😍

In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate

Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...

I’m biased… but the Mosers together are excellent at lab management (teamwork makes the dream work??)

Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition - Molecular Psychiatry Molecular Psychiatry - Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition

Awesome pub looking at the unique role of AD- and M2-projecting RSC circuits from Xiaoxiao Lin et al.
#neuroskyence
www.nature.com/articles/s41...

Thankful for a loving family, all of my super funny friends, a happy and collaborative lab environment, and my rat Rafael for giving me some beautiful data tonight 🤩🥰🍗

While this result is really exciting, the paper also contains some hidden gems. Ext Data Fig. 3, for instance, show the power spectrum of ripple occurrence. It reveals that ripple rates fluctuate not only on a 24-hour circadian cycle but also on a 4-hour ultradian cycle.

5/

Nice recap of the paper :) ill post the results from our un-included diabetic animals if we can track down the figures

Very timely piece. With 3-4 probes per rat and ultra long recordings, I’ve already generated 95TB of data for a single project. Thinking lots these days about how to store and publish all of this… 😬😬

Raw files vs. spike times x behavior or something in between?? Or both?

go.bsky.app/LdtUYZS

I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.

Tell me who I haven’t found yet

Now out in Neuron! We benchmark place cell models using a massive CA1 dataset—nearly 70,000 rate maps—collected as mice explore environments with different geometries

BVC models perform remarkably well, but we hope this dataset/approach becomes a resource for testing/refining place cell models

This paper adds to a nice list of papers recently that (broadly) merge brain and body biology:

The others one are www.biorxiv.org/content/10.1...

And www.nature.com/articles/s41...

Recurrent Inhibitory Dynamics in the Entorhinal Cortex Support Pattern Separation The entorhinal cortex (EC) provides the major input to the hippocampus (HPC). Numerous computational models on the EC propose that its grid cells serve as a spatial metric, supporting path integration...

Super-psyched to share this preprint from my student Yicong (Alan) Zheng: "Recurrent Inhibitory Dynamics in the Entorhinal Cortex Support Pattern Separation" www.biorxiv.org/content/10.1... It's a new biologicaly-based computational model of the entorhinal-hippocampal system. Thread (1/?)