Carter Brzezinski

This is a really cool transformation, congrats to all involved. Can say from firsthand experience that a lot of those existing 2-H indazole synthesis don’t work as well as advertised (at least in my hands…)

this is such a awesome transformation, congrats to everyone! Kyle and I are real interested in a few of these products in particular 😎

no worries! this one has been haunting me for a bit. thanks for sharing it!

might have missed it but did you post a solution for this one?

Chicago: if you’re around the southside, the point is a beautiful park around the lake. Also Strings is an amazing ramen place in Chinatown - very easily accessible from the train

Lots more on this project that I cant share quite yet, but special thanks to the Sieber lab at TUM for hosting me in Munich to learn and perform these chemoproteomic experiments! Lipoprotein trafficking is clearly an attractive target for gram(-)’s, especially for beta-lactamase expressing bacteria.

We then demonstrated that OXA-23, the beta-lactamase that confers resistance, is itself an outer-membrane lipoprotein. Inhibiting lipoprotein trafficking via LolF thus also causes over-accumulation of OXA-23 to the inner membrane, which exaggerates these inhibitor’s antibiotic properties.

To understand this unique effect, we used a photoaffinity probe of this HTS hit to assign the Lol complex as the protein target of this compound! Resistance selection, Lol overexpression, and CRISPR studies also confirm lipoprotein trafficking as the major MOA.

Also, an awesome collaborative paper I worked on during my PhD is now published in PNAS!

www.pnas.org/doi/10.1073/...

Our collaborators discovered a small molecule that is a BETTER antibiotic against beta-lactam resistant bacteria than beta-lactam sensitive ones. We wanted to understand why.

ATL Roller Derby Pride match! Highly recommend checking out if there’s a team near you :)

nice turnout in ATL!

Free Drug Concepts: A Lingering Problem in Drug Discovery

J Med Chem is on 🔥 with the editorials lately, and I highly recommend giving this one a read. Understanding free drug principles is the gateway to all of pharmacology, and is all too often mangled and misapplied by drug discovery practitioners.

literally just had to do this for all my procedures for an SI… add this to the list of things AI could probably do that would be useful 🥲

A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.

Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9

never used it, but always thought the Beckmann rearrangement was a neat and weird one

Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes - Nature Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other multidrug-resistant bacterial species.

Nature research paper: Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes

https://go.nature.com/4igrfC1

The Cation−π Interaction in Chemistry and Biology The cation−π interaction is an important noncovalent binding force that impacts all areas of chemistry and biology. Extensive computational and gas phase experimental studies have established the pote...

Dougherty (Chem Rev 2025 ASAP) The Cation−π Interaction in Chemistry and Biology (currently free to read) #PhysChem #CompChem #cheminformatics #chemsky 🧪
doi.org/10.1021/acs....

Thanks Dr. Rouhier! Hope all is well back on the hill :)

My PhD Defense is tomorrow!! If you’re interested in hearing about some soon-to-be published work on the discovery and synthesis of new gram-negative antibiotic compounds with a unique mechanism of action, DM for a zoom link!

tbh I’m trying to be both at the same time

yikes same, didn’t realize this…

SuFEx-Enabled Direct Deoxy-Diversification of Alcohols We introduce a new use of sulfonyl fluoride as a bifunctional reagent that facilitates the one-step deoxy-diversification of complex alcohol libraries. Our reaction design features a Sulfur(VI) Fluoride Exchange (SuFEx) mediated activation of alcohols and fluoride-induced activation of silicon-bound nucleophiles. This method enables the direct conversion of alcoholic C–O bonds in complex molecules into diverse analogues via C–C, C–N, C–Cl, and C–Br bond formation while suppressing any elimination side-products.

pubs.acs.org/doi/abs/10.1...

Also Amaechi Odoh (currently at Abbvie I think? Was at Clemson) who published this killer SUFEX paper!!

@lmkdassama.bsky.social, who just published an awesome review on gram(-) antibiotic drug discovery!

Corey ylide ftw, love that reagent

Now this is civil disobedience 🔥🔥🔥

Bag of gloves and towels - figured it was something Sn!

What was the Golden Age of Antibiotics, and how can we spark a new one? Many antibiotics were developed during the “Golden Age of Antibiotics”. How did it happen, why has antibiotic development slowed down since then, and what can we do to reignite it?

Many antibiotics were developed during the “Golden Age of Antibiotics.”

In this short explainer, @scientificdiscovery.dev explains how that happened, why antibiotic development slowed down since then, and how we could speed up development again

ourworldindata.org/golden-age-a...

Identifying Opportunity Targets in Gram-Negative Pathogens for Infectious Disease Mitigation Antimicrobial drug resistance (AMR) is a pressing global human health challenge. Humans face one of their grandest challenges as climate change expands the habitat of vectors that bear human pathogens...

Delighted to share this Outlook that @isaacapaddy.bsky.social and I worked on, now out in ACS Central Science! In this forward-thinking piece and call-to-action, we try to identify "druggable" points of vulnerability in non-model pathogenic bacteria! pubs.acs.org/doi/10.1021/...

Synthesis games for chemists to puzzle over From problem set to puzzle game

If you like Synthordle, perhaps you'll enjoy the backstory -- which involved a would-be summer intern who wouldn't take "we'd love to hire you, but can you come back when you're 16?" for an answer.

cen.acs.org/education/Sy...

IMO a poster session is way more valuable for students, esp if you’re still in the problem-solving stage of a project. I have recieved way more suggestions and useful ideas at posters than the few times I’ve given a talk.