Lars Bock

Awesome to see this epic piece of work, led by @cecclementi.bsky.social, finally appear in @natchem.nature.com.

The development of a general coarse-grained protein forcefield to describe folding, binding and conformation changes without solvent and all-atom, has been long anticipated!

Dynamics and Energetics of Ribosomal Translation

🐦 For the early birds and #ribosome #MD and #ML enthusiasts #EBSA2025: Don't miss 📌 Lars' @larsvbock.bsky.social oral presentation (O-16.1) tomorrow at 8:30 during session 16 in hall 1: "Combining #Simulations and Machine Learning with Experiments to Explore Ribosomal #Translation" 🔗 t1p.de/ccmwk

One day remaining before this closes!
bsky.app/profile/benj...

🆕📣 Job alert: Our department @compbiophys.bsky.social is looking for a PhD student or Postdoc specializing in theory and methods for non-equilibrium theory and atomistic simulations of complex biomolecules.
More information here: ⬇️

💭 Would you like to contribute to projects in the field of "Theory and Methods for Non-equilibrium #Theory and Atomistic Simulations of Complex# Biomolecules"? Join our department as #PhD student or #Postdoc at @mpi-nat.bsky.social in 🇩🇪 🔗 Here are more details www.mpinat.mpg.de/4965656/10-2... #job

Structural switching dynamically controls the doubly pseudoknotted Rous sarcoma virus–programmed ribosomal frameshifting element | PNAS A hallmark of retrovirus replication is the translation of two different polyproteins from one RNA through programmed –1 frameshifting. This is a m...

Excited to share my latest research. In this paper in PNAS, I use #cryoEM and #crystallography to solve multiple new structures of a viral RNA motif that controls frameshifting.

#virus #retrovirus #structuralbiology #science #biochemistry

www.pnas.org/doi/10.1073/...

🧐 Are you a computational physicist and expert in probability theory? 👉 Contribute to our project "Theory and Algorithms for Structure Determination from Single Molecule X-Ray Scattering Images" as PhD student or Postdoc! 🔗 Check our job advert for more details www.mpinat.mpg.de/4988122/09-2...

Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing

More details about the project including how to apply in the link below. Deadline April 9 2025

candidate.hr-manager.net/ApplicationI...

Oh to be a little Tardigrade scratching its back on a bubble. 🫧🐻🧪

"A screenshot of an NBC News article headline. The headline reads: 'Texas bill would make identifying as transgender a felony punishable by jail.' Below the headline, a subtext states: 'The bill, while unlikely to pass, highlights the increasing extremism of legislation targeting trans people, especially in Texas, in recent years.' The NBC News logo is visible at the top, along with a navigation bar that includes a 'WATCH' button and a user profile icon."

I need y'all to sit with this headline and understand what is being done to our community. They're trying to criminalize our very existence.

This is a campaign of eradication.

www.nbcnews.com/nbc-out/rcna...

There was a lot of #AcademicFreedom, good scholarship, and independent thought in German universities before Hitler. After Hitler had risen to power, many academics fled the country. Some resisted the Nazi regime and were persecuted. Most adapted to a new situation. Here are some examples. 1/n

There have been people less than helpful in my journey here. I wanted to acknowledge those too, bc I know I am not unique in this experience. No thank you to the physics study assoc that made me sing songs about how women couldn't study physics without sleeping with the professor, the day I stepped into university life. No thank you to the 5th year physics student that decided to assign me a stripper name within the first minute of meeting me in the physics coffee corner in my first year. No thank you to the technician that was responsible for onboarding me on the use of the cluster in my third year who raised his eyebrows and asked me if that meant I was some sort of computer girl. No thank you to the senior researcher that sent me utterly inappropriate texts after a conference, then proceeded to apologise months later by telling me they had not been meant for me anyway so no hard feelings remain hopefully And no thank you to him for attending every conference I've been to since. No thank you to the people who told me that it was surprising that I was doing a PhD since I was a girl. No thank you to the man who mistook me for a coffee lady at a conference, and after having to correct him two times that I did not work there, responded with you should consider it. No thank you to the researcher that asked me what I was wearing underneath my outfit during a conference. No thank you to the physicist who declared to a room full of other physicists that biologists don't know how to design an experiment. No thank you to the people who have called me scary instead of strong and intimidating instead of intelligent. And finally, no thank you to the exec board of the TU Delft, whose knee-jerk reaction to being held up a mirror about the social safety at the university, was to sue the party holding up the mirror instead of looking at the problems they highlighted. ... You have made me feel like I do not belong in science & I cannot forgive you for that.

A friend included this anti-acknowledgement section on her PhD thesis. She also added the proposition: “Systematic bullying and undermining of girls and women in STEM starts early on and is the reason why they do not stay in science and related fields.”
Absurd we still need to go through this
🧪👩‍🔬

🥹 Last day at #bps2025 and a 🤩 final poster session with contributions from our group @compbiophys.bsky.social @mpi-nat.bsky.social: Meet Annke, Lars @larsvbock.bsky.social and Malte during today's session 10:30 AM -12:30 PM and discuss their exciting projects with them before you say goodbye...👋

🚨The triennial Ribosome Conference will be held June 22-June 27, 2025 in Pacific Grove, California. Registration is open - hope to see many #Ribosome #RNA aficionados there. #RNASky #AcademicSky 🧪 rna.ucsc.edu/rnacenter/ri...

We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227

We proudly present a selection of research projects from @compbiophys.bsky.social at this year's #bps2025 meeting in LA! Don't miss the oral presentations or posters being presented and find us in the program biophysics.cld.bz/BPS2025-Full...

Recharging batteries in Sta Monica with @compbiophys.bsky.social. Come and reach us in #bps2025! (Contributions listed in the comments)

@reinierdevries.bsky.social
@larsvbock.bsky.social
@steschuu.bsky.social @oberend.bsky.social

If you are interested in postdoctoral research on ligand-gated ion channels and the synapse, or simulation/AI methods for structural biology - drop me a line if you'll be around at Biophysical Society in LA! #bps2025 #bps #biophysics

📢 Out now: Our double feature “Constant pH #cpH Simulation with #FMM Electrostatics in #GROMACS” #openaccess in #JCTC on 🅰️ Design and Applications and 🅱️ GPU Accelerated Hamiltonian Interpolation #HI! 👇 Happy simulating! ☺️

The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics

A view through many Prague towers towards a sunset.

Join us in beautiful Prague to study molecular physics. My group is offering a PhD position at UCT Prague, Czechia related to #protein - #RNA interactions. For more details, visit mhko.science/p/positions/ or contact us directly at positions@mhko.science.

Over 60 German unis and institutes jointly announce they're leaving X due to the "lack of compatibility between the platform and the institutions' core values" (my translation)
nachrichten.idw-online.de/2025/01/10/h...

FIB-SEM dataset visualized with Microscopy Nodes, data from Mocaer et al 2023

Microscopy Nodes is now up on bioRxiv! 🚀

This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).

High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬

www.biorxiv.org/content/10.1...

Are you interested in exploring RNA with cutting-edge techniques in a dynamic, collaborative and international environment? Just click below to learn more or send me a message. We will be happy to connect and discuss this further!

Dear Colleagues in the RNA field, please RT and spread the word :)

📢 Our new paper in #SciAdv on #Bayesian electron density determination from single-molecule #X-ray scattering is out! 🧐 High resolutions can be achieved from #XFEL exp at low S/N ratios using less than 50 #photons per image! 🔗https://www.science.org/doi/10.1126/sciadv.adp4425 @mpi-nat.bsky.social

Systematic analysis of biomolecular conformational ensembles with PENSA Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system

Molecular simulations or AI models produce ever larger and more complex datasets. Comparing different conditions to find meaningful patterns is a bottleneck for many projects.

We address this with PENSA, a flexible open-source analysis library.

Now out in JCP:
doi.org/10.1063/5.02...

🧪 #CompChem

Postdoc of molecular data science

Want to come work with me? Short postdoc opportunity. Deadline tomorrow ⚡️ jobportal.ku.dk/videnskabeli...

Abstract submission for the 2025 Free Energy Workshop are now open! Submissions will be accepted from December 1st to January 15th.
bit.ly/FEW2025Abstr...

We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to positions@mhko.science.

In this work, we use all-atom MD simulations to elucidate why human and rhesus macaque TRIM5α differ in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --