Amulya Sreekumar

Check our new venture into drug discovery #glycotime!

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...

Comprehensive experiments in pre-clinical models and clinical data analysis demonstrate that dormancy creates a unique window of opportunity to deplete minimal residual disease and delay recurrence. Congratulations to all the authors on this important body of work!

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

World central kitchen has been doing great work consistently. Every meal counts. Donate here.

donate.wck.org/give/525879/...

Congratulations!! 🥂

As a budding scientist, the idea that form follows function led me to a career studying developmental biology and how these principles are distorted in cancer. Excited to share this preprint reporting a surprising transdifferentiation of breast cancer cells unlocked by dormancy. Link below:

AACR Legislative Action Center Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

Done!

Pathway to independence: a new initiative supporting postdocs on the job market

Apply for our Pathway to Independence programme, a scheme supporting postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: https://buff.ly/3VJGgDC

#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!

Done!

Of course!

The secret is out! 🚀 Thrilled to support Valora's mission to bring our #AbLec technology to patients, alongside co-inventor @carolynbertozzi.bsky.social. More to come, and in the meantime, you can learn more about AbLecs here:
www.biorxiv.org/content/10.1...

Done!

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...

Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy

pubmed.ncbi.nlm.nih.gov/39001819/

Enjoy!

Done! Nice seeing you here Lance

Of course! You're on the list

Done!

Done!

Thanks, Manuel! You're in the pack.

Done!

B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling Sreekumar et al. identify a previously uncharacterized function for the galactosyltransferase B3galt6 in cancer, specifically enabling dormant residual tumor cell survival following therapy or in a re...

Thank you to the organizers of #SFG2024 for hosting a wonderful meeting @sfglycobiology.bsky.social

As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.

www.cell.com/cancer-cell/...

#SFG24 was so much fun - amazing #glycotime in a fantastic place. The right mix between talks by legends in the field and early career colleagues. Thank you to the organizers!
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...

For those of you that prefer feeds over following, I've figured out how to convert starter packs into lists, so you can get your glyco fix as a feed. If you're on the starter pack, you're on the list, and anyone new on the starter pack will get added to the feed!

Of course! Just added you

Of course! You're on the list!

Beautiful crow against a black background

It seems to me that the time is ripe for a Bluesky thread about how—and maybe even why—to befriend crows.

(1/n)

Done! Also, congrats on a wonderful talk at SFG this morning