Jose M. Adrover

🔥Trio Fatale: Neutrophils, NETs and Necrosis
👉 authors.elsevier.com/a/1lk-k3qNrU...

We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau

Congrats!

A new model of #TumorNecrosis👹

Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis

a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...

Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...

#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation

#Cancer patients display an elevated burden of #CardiovascularDisease. This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...

Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social

rupress.org/jem/article/...

Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis Major Finding: A Ly6GhighLy6Clow subset of neutrophils drives pleomorphic necrosis by forming intravascular neutrophil extracellular traps (NET).Concept: Tumor cells adjacent to neutrophil-induced nec...

Thanks to Cancer Discovery for highlighting our manuscript with such a nice summary!

Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...

@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis

go.nature.com/4lzilSb

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com

This project started when I joined the @megeblad.bsky.social lab at @cshlnews.bsky.social, and continued at @hopkinsmedicine.bsky.social and at
@crick.ac.uk, with help from many colleagues along the way! It has been an absolute pleasure to work with Mikala and the rest of the team! (13/13)

We show, therefore, that tumour necrosis is not a passive phenomenon, but an active phenomenon that we can target by targeting neutrophils or their NET formation ability. And by reducing tumour necrosis we can reduce metastatic spread. (12/13)

There, they form NETs and enter a feedforward loop with platelets that ultimately leads to the blockage of blood flow and subsequent necrosis of downstream tumour regions. This induces cancer cells around these necrotic regions to change and become more metastatic. (11/13)

In summary, we found that the tumour changes the haematopoietic compartment and drives the production of vascular-restricted neutrophils. Then, neutrophils leave the bone marrow and enter the bloodstream, eventually reaching the tumour vasculature. (10/13)

These neutrophils form NETs more efficiently than normal neutrophils, interact more with platelets, and, intriguingly, cannot extravasate and are stuck in the vasculature. We called them vascular-restricted neutrophils (vrPMNs). (9/13)

But why are neutrophils forming NETs in the vasculature? We found that the tumour communicates with the bone marrow and changes myelopoiesis to produce a novel neutrophil subpopulation. (8/13)

Using spatial transcriptomics, we found that tumour necrosis increased metastasis because cancer cells in peri-necrotic areas gained pro-metastatic traits in a TGFb-driven manner. (7/13)

We found that the process was driven by NETs. When we block NETs genetically or pharmacologically, tumour necrosis is greatly reduced. This, interestingly, also reduced metastatic spread. (6/13)

These aggregates were blocking blood flow in the tumour, and that caused the necrosis of downstream tumour regions. (5/13)

Interestingly, around necrotic regions we found vessels that contained intraluminal aggregates of neutrophils, NETs and platelets. (4/13)

We found that the architecture of necrosis was peculiar and intricate in different tumour models (we call it “pleomorphic necrosis”), and these regions were covered by neutrophils and NETs. (3/13)

Tumour necrosis is associated with a bad prognosis across the board of cancer types, including in breast cancer. But it was thought to be a passive phenomenon due to cancer growth outpacing nutrient supply. (2/13)

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Open call for a Postdoctoral Fellow - Cancer Macroenvironment Lab Open postdoctoral position at the Cancer Macroenvironment Lab led by Dr. Adrover at the Francis Crick Institute in London

Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here: adroverlab.com/open-positio...

Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…

💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵

www.sciencedirect.com/science/arti...

I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!

William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer.

#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk

If you’re attending #AACR25 stop by and say "Hi!" to our colleagues in @cancergrand.bsky.social at stand 2327, and Cancer Tools at stand 2424 in the exhibition hall.

View of Chicago by night

I’m thrilled to be presenting our work next Monday the 28th at the #AACR25 in beautiful Chicago!