Paula Nieto

🌍 Baking for a better world — one cookie at a time!
On June 25, from 9–11:30h at Parc Científic de Barcelona, we’re selling organ-themed cakes & cookies to raise funds for the DTI Foundation.

Donation & transplantation save lives💚

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer - Nature Communications ‘T cell engagers promote antitumor immunity, but how macrophage modulates this activity in tumor is still unclear. Here the authors show, using biopsies from patients with uveal melanoma and single ce...

🚀New research published in @naturecomms.bsky.social!
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG

📎 www.nature.com/articles/s41...

Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes - Oncogene Oncogene - Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes

📢New paper out in Oncogene!

➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)

📎 www.nature.com/articles/s41...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer - Nature Communications ‘T cell engagers promote antitumor immunity, but how macrophage modulates this activity in tumor is still unclear. Here the authors show, using biopsies from patients with uveal melanoma and single ce...

I'm thrilled to finally share the publication of this collaborative paper in @naturecomms.bsky.social ! Excited to contribute to the immuno-oncology field and can’t wait to see where this takes us! Check it out here: nature.com/articles/s41...
#SingleCell @cnag-eu.bsky.social @hoheyn.bsky.social

Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes - Oncogene Oncogene - Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes

Excited to share a paper I recently collaborated on, now published in Oncogene! 🧬 It was great working on this with an amazing team. Check it out here: www.nature.com/articles/s41...
#melanocyte #oncology #research #collaboration
@cnag-eu.bsky.social
@vhio.bsky.social

🏆Exciting news! Our colleague Gerard Dauner has won the
VHIO Computational Oncology Master Thesis Award

His research, supervised by @paulanietog.bsky.social and
@hoheyn.bsky.social, explores immune dynamics in colorectal and endometrial cancer metastases

#CancerResearch #CNAG @vhio.bsky.social

Big thanks to @paulanietog.bsky.social , @piazeiner.bsky.social , @hoheyn.bsky.social & the team for this collaboration! 🚀 Our study shows how CSF liquid biopsy mirrors CNS tumor immunity using single-cell & spatial transcriptomics. Insights into T cell responses, myeloid dominance & biomarkers!

Excited to collaborate with @hoheyn.bsky.social, @jcnietos.bsky.social, @paulanietog.bsky.social & team on leptomeningeal metastatic disease - a key challenge in #NeuroOncology. Our study reveals unique immune responses in CSF, highlighting CSF liquid biopsy’s potential to guide CNS tumor therapies.

Nice way to begin my journey in the blue platform 🤓

📖 Want the full story? Check out our preprint for more on how immune profiling of CSF is changing our understanding of CNS diseases:

t.co/DbDFmnKe8x

🧠 This study highlights CSF as a window into brain immune activity and tumor biology. Single-cell technologies paired with liquid biopsies pave the way for non-invasive diagnostics and precision oncology 🚀💥

🛠 This has relevant clinical implications:
💪 CSF profiling can guide personalized therapies: i.e. identify active immune responses and monitor therapy resistance
💪 It brings us a step closer to using CSF for tailored cancer treatments

🧫 The Myeloid landscapes of CNS lymphomas and inflammatory diseases presented infiltrating macrophages whereas glioblastomas and brain metastases have more resident-like macrophages and showed relevant metabolic reprogramming (e.g., lactate production).

🔄 Regarding T cell dynamics, CD8 T cells showed high clonal expansion and activity in CNS lymphomas whereas exhausted and regulatory T cell phenotypes dominated in glioblastomas and brain metastases, hinting at immune evasion 😶‍🌫️

We found distinct immune profiles in the CSF:
1. Robust T cell activation & clonal expansion in CNS lymphoma
2. Myeloid-dominated CSF, w/ fewer T cells in glioblastomas & brain metastases
3. Lymphoid cell dominance reflecting active immune responses in CNS inflammatory disorders

💡 Our goal was to establish CSF as a minimally invasive "liquid biopsy" that mirrors brain immune responses.
Therefore enabling:
- Immune response tracking
- Monitoring tumor progression
- Identifying therapy resistance
- Unlocking new biomarkers

This work has been a huge effort where we applied:
✅ Single-cell RNA sequencing
✅ Single cell and deep TCR sequencing
✅ Cell-free DNA sequencing
✅ Spatial transcriptomics
of cerebrospinal fluid and matched blood and brain tissue pieces of patients suffering from CNS diseases.

📢 SUPER EXCITED to share our latest preprint:
Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid

Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others.
biorxiv.org/content/10.110…