Markus Elsner

🚨 Group Leader Opportunity Alert! 🚀
Apply by February 15 and join us in Würzburg. ⬇️

Sollen wie euch mal was sagen?
Diese Woche kommt eine neue Folge! 🥳

(Ja, wir fanden es auch lang, aber *schaut sich in der Welt um*… 🤷‍♀️🤷🏻‍♂️🤷🏼‍♂️🤷‍♂️)

Scalable and multiplexed recorders of gene regulation dynamics across weeks - Nature Nature - Scalable and multiplexed recorders of gene regulation dynamics across weeks

In @natureportfolio.nature.com: CytoTape is a protein-based recording system that lets cells store long-term gene activity histories in situ. It enables multiplexed, single-cell measurements over days to weeks without continuous live imaging 👏 @changyanglinghu.bsky.social & @denisejcai.bsky.social

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.

If you are looking for a distraction, this seems cool. Sticky ends++. If it works as advertised, seems like it could be a game-changer.
www.nature.com/articles/s41...

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities @natcomms.nature.com
www.nature.com/articles/s41...

Review @natrevdrugdiscov.nature.com @grieshaber.bsky.social @biohacker.bsky.social
Roads and detours for CAR T cell therapy in autoimmune diseases
www.nature.com/articles/s41...

Brings back some PhD time PTSD
😜

Recruitment for the EMBL International PhD Programme is officially open! 🔊

At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry and other sectors. Start your career in the life sciences with us!

🔎 Read more here:
tinyurl.com/4jdt2ra5

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...

Computational enzyme design by catalytic motif scaffolding | Nature Enzymes find broad use as biocatalysts in industry and medicine owing to their exquisite selectivity, efficiency and mild reaction conditions. Custom-designed enzymes can produce tailor-made biocatalysts with potential applications that extend beyond natural reactions. However, current design methods require testing a large number of designs and mostly produce de novo enzymes with low catalytic activities1–3. As a result, they require costly experimental optimization and high-throughput screening to be industrially viable4,5. Here we present rotamer inverted fragment finder–diffusion (Riff-Diff), a hybrid machine learning and atomistic modelling strategy for scaffolding catalytic arrays in de novo proteins. We highlight the general applicability of Riff-Diff by designing enzymes for two mechanistically distinct chemical transformations, the retro-aldol reaction and the Morita–Baylis–Hillman reaction. We show that in both cases, it is possible to generate catalysts that exhibit activiti

Innovative method in enzyme design uses catalytic motif scaffolding to enhance efficiency, minimizing costly trials and boosting enzyme activity. PMID:41339546, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-09747-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@biorxivpreprint.bsky.social Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity
www.biorxiv.org/content/10.6...

Wie kann man einen Weinberg nachhaltiger machen?

Ein Video der Hochschule Geisenheim zeigt es:
geistreich.hs-geisenheim.de/geistreich-i...

We are looking for a PhD student to join our project on developing AI-driven, whole-body multi-omics atlases of mammalian organisms:
www.linkedin.com/jobs/view/43...

Deep Piction | Ali Maximilian Ertürk Most of the hardest diseases are systemic. Long COVID is a clear example. Multi organ biology, heterogeneous patient biology, and too little direct visibility into mechanisms and drug action. At Deep...

Our lab's start-up @deeppiction.bsky.social is now developing a therapy for Long Covid:
www.linkedin.com/posts/ali-ma...

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

New preprint on technologies to scale up CRISPR screens.

We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.

We also introduce an approach for cloning lentiviral libraries with billions of elements.

Locum Associate or Senior Editor Job Title: Locum Associate or Senior Editor (Chemical Biology / Biological Chemistry), Nature Chemistry Company: Nature Portfolio Contract Type: Full-time, Fixed Term (maternity leave cover) Location(...

We're hiring! We're looking for a Locum Editor to cover our chemical biology/biochem. The role can be located in either our London or Pune offices. Planned start date is June 1st. Closing date for applications is Feb 2nd. #chemjobs #chemsky springernature.wd3.myworkdayjobs.com/SpringerNatu...

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections - PubMed Analysis of entire transparent rodent bodies after clearing could provide holistic biological information in health and disease, but reliable imaging and quantification of fluorescent protein signals deep inside the tissues has remained a challenge. Here, we developed vDISCO, a pressure-driven, nano …

In case you are interested in our papers:
pubmed.ncbi.nlm.nih.gov/30598527/
pubmed.ncbi.nlm.nih.gov/37562402/

Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy Drug-loaded albumin NPs hijack calvarial immune cells to bypass the BBB via skull-meninges microchannels for CNS drug delivery and stroke therapy, establishing skull-based delivery and immune-assisted...

Check out this fascinating paper that describes the use of immune cells trafficking from the skull bone marrow to sites of injury in the CNS for drug delivery:
www.cell.com/cell/fulltex...

Incidentally, it builds on pathways that our group has contributed to discovering (among others, of course)

I had no idea!

🚨 The deadline has been extended until January 31st!🚨

💯

Is this real or a joke?

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

This is such a cool illustration of how the Mercator map distorts the size of Greenland, which looks as big as the whole continent of Africa on that map but is actually the size of Mexico.

#chembio and #bioorganic crowd. Mark your calendars for ESBOC 2026, registration opens soon!

www.esboc.org.uk

⏱️ 27th-30th May 2026
🏰 The beautiful Schlosshotel Pillnitz GmbH in Dresden/Germany

Now Europe is sandwiched between two enemies that threaten war to obtain its territory.
Hard to believe for someone whose world view has been shaped in the 90s
:(

You are forgetting the FIFA peace prize

Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org