Kyoto University develops protein to help remove cancer cells
The protein binds to unwanted cells to make it easier for immune cells to pick out their target for removal.
If you are interested in reading more about Crunch (and seeing candid shots of Suzuki-sensei), here are a few news links! ๐ฐ
English:
www.japantimes.co.jp/news/2025/09...
Japanese:
www.nikkei.com/article/DGXZ...
Korean:
www.medipana.com/article/view...
Chinese:
geneonline.news/%E4%BA%AC%E9...
09.09.2025 07:52 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Phagocytic clearance of targeted cells with a synthetic ligand - Nature Biomedical Engineering
A synthetic protein ligand enables the recognition of surface proteins on unwanted cells, targeting them for engulfment and elimination in vivo.
Yamato-sanโs research on Crunch was just published in Nature Biomedical Engineering!!
What is Crunch? ๐ค
Crunch is a tool we developed to remove non-dying cells by taking advantage of MerTK-mediated cell engulfment. ๐ฝ๏ธ
doi.org/10.1038/s415...
09.09.2025 07:47 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
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If you would like to find out more about testicular in vivo revival screening, the method is detailed in this Star Protocol paper: doi.org/10.1016/j.xp... ๐ฆ ๐๐
14.03.2025 06:16 โ ๐ 0 ๐ 1 ๐ฌ 0 ๐ 0
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Not only can revival screening be used in vitro, it can also be used in vivo! ๐
Using in vivo revival screening, Noguchi-san identified Rd3 as a significant factor in spermatogenesis
doi.org/10.1016/j.xg...
14.03.2025 06:13 โ ๐ 0 ๐ 1 ๐ฌ 0 ๐ 0
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What is revival screening? In this Molecular Cell paper, Dr. Maruoka illustrates how he was able to use this method to screen for sgRNAs enriched in dying cells ๐ต
Interested? Read more here: doi.org/10.1016/j.mo...
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Physicist | Editorial Development @rsc.org for Japan and Korea regions | Views expressed here are mine โ๏ธ๐
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Cell biologist at NIH researching mechanisms of protein and organelle transport, and related diseases. Special interest in neurons and neurodevelopmental disorders. Passionate about science, nature, travel, and music. Views are my own.
Research group leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany.
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She / her
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Biologist recognized worldwide for her groundbreaking work leading to the revolutionary CRISPR-Cas9 genome engineering technology.
Visit: <www.emmanuelle-charpentier.org>