Suzuki Laboratory's Avatar

Suzuki Laboratory

@jsuzukilab.bsky.social

Understanding biology phenomena at a molecular level ๐Ÿงซ Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University Graduate School of Biostudies, Kyoto University https://www.suzuki.icems.kyoto-u.ac.jp/en/

24 Followers  |  42 Following  |  8 Posts  |  Joined: 26.12.2024  |  1.5502

Latest posts by jsuzukilab.bsky.social on Bluesky

Preview
Kyoto University develops protein to help remove cancer cells The protein binds to unwanted cells to make it easier for immune cells to pick out their target for removal.

If you are interested in reading more about Crunch (and seeing candid shots of Suzuki-sensei), here are a few news links! ๐Ÿ“ฐ

English:
www.japantimes.co.jp/news/2025/09...

Japanese:
www.nikkei.com/article/DGXZ...

Korean:
www.medipana.com/article/view...

Chinese:
geneonline.news/%E4%BA%AC%E9...

09.09.2025 07:52 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Phagocytic clearance of targeted cells with a synthetic ligand - Nature Biomedical Engineering A synthetic protein ligand enables the recognition of surface proteins on unwanted cells, targeting them for engulfment and elimination in vivo.

Yamato-sanโ€˜s research on Crunch was just published in Nature Biomedical Engineering!!

What is Crunch? ๐Ÿค”
Crunch is a tool we developed to remove non-dying cells by taking advantage of MerTK-mediated cell engulfment. ๐Ÿฝ๏ธ

doi.org/10.1038/s415...

09.09.2025 07:47 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Phospholipid scrambling induced by an ion channel/metabolite transporter complex - Nature Communications Phospholipid scrambling is used by cells to alter lipid asymmetry on the plasma membrane. Here, the authors performed CRISPR screenings to identify a heterodimer formed by Tmem63b and Slc19a2 that ind...

Niu Han-san identified a new scramblase, TMEM63b ๐Ÿคฉ

doi.org/10.1038/s414...

14.03.2025 06:21 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4 - Nature Communications Dying cells display an โ€œeat meโ€ signal through phospholipid scrambling. Here, the authors show that activation of the plasma membrane-bound Xkr4 scramblase requires extracellular calcium as a โ€œmolecul...

We also love scramblases!
Panpan-san elucidated the importance of calcium in the activation of Xkr4

doi.org/10.1038/s414...

14.03.2025 06:19 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Redirecting

If you would like to find out more about testicular in vivo revival screening, the method is detailed in this Star Protocol paper: doi.org/10.1016/j.xp... ๐Ÿฆ ๐Ÿ’‰๐Ÿ€

14.03.2025 06:16 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Redirecting

Not only can revival screening be used in vitro, it can also be used in vivo! ๐Ÿ€

Using in vivo revival screening, Noguchi-san identified Rd3 as a significant factor in spermatogenesis

doi.org/10.1016/j.xg...

14.03.2025 06:13 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Redirecting

What is revival screening? In this Molecular Cell paper, Dr. Maruoka illustrates how he was able to use this method to screen for sgRNAs enriched in dying cells ๐Ÿ˜ต

Interested? Read more here: doi.org/10.1016/j.mo...

14.03.2025 06:08 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Genome-Wide Screening Approaches for Biochemical Reactions Independent of Cell Growth | Annual Reviews Genome-wide screening is a potent approach for comprehensively understanding the molecular mechanisms of biological phenomena. However, despite its widespread use in the past decades across various bi...

Suzuki Lab has moved to Bluesky!
Want to find out more about our lab? Weโ€™ve summarized current screening systems, including revival screening, a key technique developed in our lab, here: doi.org/10.1146/annu... ๐Ÿ”‘

14.03.2025 06:01 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@jsuzukilab is following 20 prominent accounts