Sri Narasimhan

50,000 years of evolutionary history of India: Impact on health and disease variation A genomic study of 2,762 individuals from India offers important insights into the genomic diversity and evolutionary history of the subcontinent and highlights the extensive genetic variation, gene f...

Our paper out today: 50,000 years of evolutionary history of India: Impact on health and disease variation: Cell www.cell.com/cell/fulltex...

‘Wildest thing’: solar-powered slug steals chloroplasts and stores them for emergencies Marine creatures house contraband structures in special organelles, which the animal raids for food in times of need.

Did you know that sea slugs steal chloroplasts from algae as portable snacks?! Neither did I, but a new Cell paper demonstrates that they do. 🐌🧪

My favorite part is the researchers called the storage for these stolen hors d’oeuvres “kleptosomes” 😂🥰

Summary from Nature & Cell paper linked below.

Elsevier Jobs Elsevier is a global information analytics business that helps institutions and professionals advance healthcare, open science and improve performance for the benefit of humanity. We help researchers ...

Cell is hiring! 4 full-time Scientific Editors - candidates should have an PhD or MD + expertise in cancer/immunology, genetics/genomics, clinical/translational, OR computational biology/AI. Locations: Amsterdam, London, Barcelona, Tokyo, Beijing, Shanghai. Experience is a + tinyurl.com/3rrtvtrj

Scientists design gene delivery systems for cells in the brain and spinal cord NIH-funded breakthrough could enable targeted therapies for many neurological disorders.

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord.

This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.

🧠📈 www.nih.gov/news-events/...

Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at @cp-cell.bsky.social ! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below 👇

Call for Nominations!!

The 2025 Paul Farmer Lectureship and Award for Global Health Equity

www.mcgill.ca/spgh/about-u...

I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...

Interested in postdoc opportunities in Seattle, WA? Join us May 6th for Seattle DROP, a virtual event about biomedical research in Seattle. Hear from recruiting faculty, finding the right mentor and enjoy lunch on us via a delivery voucher within the US!

Registration: tinyurl.com/seattledrop25

Asian diversity in human immune cells The Asian Immune Diversity Atlas (AIDA) is a 5-nation single-cell reference atlas of circulating immune cells from healthy donors in diverse populations. AIDA highlights the impact of sub-continental human diversity on immune cell traits implicated in…

Now online! Asian diversity in human immune cells

Cell Press banner that reads "50 Scientists that Inspire: Putting a spotlight on researchers who drive innovation" The headshots of Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko are illuminated under a spotlight.

Check out our #50ScientistsThatInspire interviews with Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko threaded below🧵

@madhupai.bsky.social @johannajoyce.bsky.social @jpcorreabaena.bsky.social @kokkonut.bsky.social

Microtubules in Asgard archaea Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.

Now online! Microtubules in Asgard archaea

Screenshot of tweet from @AlecStapp “Too many people take biomedical innovation for granted.” Below this is a screenshot from an article on the Atlantic.com. Highlighted is the text: “A child born with cystic fibrosis in the 50s could expect to live until age 5. In the 70s, age 10. In the early 2000s, age 35. With Trikafta came a quantum leap. Today those who begin taking the drug in early adolescence, a recent study projected, can expect to survive to age 82.5 - an essentially normal lifespan.”

I remember the cystic fibrosis patients I took care of 20 years ago.

I also remember the dedicated HIV wards in the hospitals, and that Princess Diana made headlines for shaking hands with AIDS patients.

Progress has been incredible.

Miracles are where you choose to see them.

The most uplifting and energizing afternoon #StandupforScience #Boston

Evolution and genetic adaptation of fishes to the deep sea Genome assemblies from 11 deep-sea fishes, representing key lineages, reveal a convergent rtf1 gene mutation that affects transcriptional efficiency. Additionally, biochemical measurements challenge t...

Evolution and genetic adaptation of fishes to the deep sea www.cell.com/cell/fulltex... @cp-cell.bsky.social #deepsea #ocean #science

The amphipod genome reveals population dynamics and adaptations to hadal environment Genomic analysis of the amphipod Hirondellea gigas revealed population homogeneity within the Mariana Trench but genetic differentiation between nearby hadal features. Multi-omics analysis showed that...

Adapting and survival in the Mariana Trench: The amphipod genome reveals population dynamics and adaptations to hadal environment www.cell.com/cell/fulltex... @cp-cell.bsky.social

Microbial ecosystems and ecological driving forces in the deepest ocean sediments Metagenomic sequencing of 1,648 sediment samples from 6–11 km water depths, including the Mariana Trench, highlights the hadal microbial ecosystem and its environmental driving forces.

Exploring the Mariana Trench: Microbial ecosystems and ecological driving forces in the deepest ocean sediments www.cell.com/cell/fulltex... @cp-cell.bsky.social

Our world is incredible and we need science to lead the way. Today at Cell we proudly publish 3 papers exploring life in the deepest depths of the ocean - the Mariana Trench! Read about the MEER package fm Xing Xiao et al tinyurl.com/y5xf49dv @cp-cell.bsky.social & the papers tinyurl.com/yupkvr9v 👇

Following the NIH decision to cap funding for indirect cost reimbursements at 15%, @nygenome.org Scientific Director Tom Maniatis calls for swift, united action. cell.com/cell/fulltex...

Read his Commentary now in @cp-cell.bsky.social

NSF fact sheet

The National Science Foundation benefits communities in every state.

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

Safeguarding the future of biomedical science in the United States NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

Safeguarding the future of biomedical science in the United States - out in Cell

www.cell.com/cell/fulltex...

Paul Farmer’s Moral Clarity Offers Hope, Amidst Chaos And Darkness On the 3rd anniversary of Dr Paul Farmer's death, several leaders reflect on his lessons for dealing with the ongoing crisis in global health and development

2/2 Paul showed us that health care is a human right—not a privilege. His moral clarity continues to guide us.

@madhupai.bsky.social captures why his work matters now more than ever, read more at @forbes.com: www.forbes.com/sites/madhuk...

Measles infections and symptoms pose far more longterm risks than most realize The virus can cause “immune amnesia,” leaving patients more vulnerable to other infections.

#Measles is not done after the rash has gone away. Measles infections are followed by more disease. #science
www.nbcnews.com/news/amp/rcn...

If you are an NIH or CDC scientist that lost your job, we have a home for you at UTHealth. I’m hiring physician scientists and we also have transplant ID fellowship slots open. Contact me. #IDSky #MedSky

Someone awesome in my circle shared some terrific news with me today but was hesitant to do so because of all that is going on in the science world.

It may appear insensitive that you are celebrating when other colleagues are struggling but I entreat you to celebrate & share good news. 1/

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses The family of coronaviruses known as merbecoviruses has generally been thought to use the host cell protein DPP4 for entry, but this study shows that the merbecovirus HKU5 can enter host cells of the ...

In these 2 papers, we show that two merbecovirus clades (HKU5 & MOW15-22, distantly related to MERS-CoV) independently evolved ACE2 receptor utilization, reshaping our understanding of coronavirus evolution

Led by Young-Jun Park on our side!

@hhmi.bsky.social

www.cell.com/cell/fulltex...

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses Two coronaviruses related to MERS-CoV, which infect European Pipistrellus bats, have been found to use ACE2 as their receptor. These viruses target an ACE2 surface region distant from those recognized...

With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr

www.cell.com/cell/fulltex...

Headshots of the winners of the 5th Annual Rising Black Scientists Awards Jheannelle Johnson of Stanford and Howard University, Victor Ekuta, MD, of the Morehouse School of Medicine, Kenna Gloria Agbugba of Philander Smith University, & Nyasha Milanzi pf Michigan Technological University. Sponsored by Cell Press, Cell Signaling Technology, and the Elsevier Foundation

We are proud to announce the winners of the 5th annual Rising Black Scientists Awards! www.cell.com/news-do/risi...

Learn more about each winner and their essays now published in @cp-cell.bsky.social below. 🧵

Sponsored by #CellPress, @cellsignal.bsky.social, and @elsevierconnect.bsky.social

"The cover image shows an artery with the perivascular space and #CSF depicted as a rain cloud dripping down on #neurons in the shape of trees. Image source: Natalie Hauglund and Nadia Alzoubi." #NeuroArtFriday