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Kostas

@maybeitsyaptaz.bsky.social

PhD Student in the Varelas Lab l Boston University Med l Lung capillary injury and regeneration l πŸ‡¬πŸ‡· in πŸ‡ΊπŸ‡Έ

25 Followers  |  55 Following  |  4 Posts  |  Joined: 01.02.2025  |  1.4396

Latest posts by maybeitsyaptaz.bsky.social on Bluesky

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Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses - PubMed The increased presence of goblet epithelial cells in conducting airways of the respiratory system is common in pulmonary disorders and is often accompanied by disrupted immune and alveolar responses. ...

Our latest study is out! We investigated the effects of inducing goblet airway epithelial cells in the lung arising from YAP/TAZ inhibition, finding distinct inflammatory networks with implications for disease. Congrats to team and first author Carina!

11.09.2025 14:58 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
A1F Riding for a Reason 2025: Mr. Konstantinos Kontodimas - Alpha-1 Foundation

πŸš΄β€β™‚οΈ Excited to be riding in Escape to the Cape (Sept 26–28) to support the Alpha-1 Foundation & the American Lung Association! 🌊
Every mile helps raise awareness + funds for Alpha-1.
πŸ‘‰ Donate here: secure.alpha1.org/site/TR/Endu...

16.09.2025 03:07 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

πŸ”We found that deleting YAP/TAZ in club airway epithelial cells causes goblet cell metaplasia, which in turn sparks acute lung inflammation, showing how epithelial changes can directly fuel immune responses.

16.09.2025 02:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

🚨 New paper alert!
Thrilled to share our latest work in AJRCMB:
β€œAirway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses”
πŸ‘‰ atsjournals.org/doi/abs/10.1165/rcmb.2025-0169OC

16.09.2025 02:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche | EMBO reports imageimageLATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro-oncogenic stromal niche. Inhibitors of YAP/TAZ-TEAD activity blo...

Despite the chaos and uncertainty, I am happy to share our latest publication. In this study, we mapped stromal changes in mammary carcinomas initiated by epithelial LATS1/2 kinase inhibition and demonstrated the effectiveness of TEAD inhibitors in this model.

www.embopress.org/doi/full/10....

15.02.2025 12:59 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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I am truly honored and deeply grateful to receive the American Heart Association #AHA Predoctoral Fellowship. A heartfelt thank you to the #AHA for supporting international students through this incredible opportunity!

13.02.2025 17:44 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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