Sofía Vieto

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

17.07.2025 11:27 — 👍 62    🔁 25    💬 3    📌 1

Fig. 2 Whole-body estimates of sea otter metabolism scaled to body mass. Estimated scaled whole-body metabolic rates include predicted [BMR; predicted on the basis of scaled rate for eutherian mammals], sea otter resting metabolic rate, and whole-body skeletal muscle leak capacity.

Several mammal species live in cold-water environments thanks to adaptations like blubber and large size. A notable exception is the sea otter—so how does it stay warm?

A 2021 Science study found an answer: skeletal muscle thermogenesis.

Learn more on #WorldOtterDay: scim.ag/4jjvMDL

28.05.2025 18:28 — 👍 117    🔁 23    💬 2    📌 1

"Psychological safety" was the #1 predictor of an effective team in a study by Google. 'In other words, for a diverse team to work to its fullest capacity, everyone on the team must feel that it is safe to voice his or her opinions without being ridiculed.' 🙏@virusesimmunity.bsky.social

29.04.2025 00:32 — 👍 30    🔁 6    💬 1    📌 1

Opinion | How to Live Healthier for Longer (Gift Article) A new era of medical care is upon us.

Here's what is exciting about the science of aging
my op-ed @nytopinion.nytimes.com
as presented in depth in SUPER AGERS (out 6 May)
www.nytimes.com/2025/04/21/o...

21.04.2025 14:03 — 👍 164    🔁 42    💬 9    📌 7

Thanks for joining us @itaiyanai.bsky.social We had a great time hosting you! You really know how to engage an audience 🥳

17.04.2025 02:34 — 👍 3    🔁 0    💬 1    📌 0

Don’t miss @alazozcan.bsky.social talking about neutrophils of the skin. She’s amazing!!

04.04.2025 18:31 — 👍 2    🔁 0    💬 1    📌 0

Opinion | The Uncertain Fate of the Young American Scientist (Gift Article) Young researchers are choosing between staying in science and staying in the United States.

www.nytimes.com/2025/04/03/o...

Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

04.04.2025 07:32 — 👍 481    🔁 305    💬 18    📌 57

Matrix-producing neutrophils populate and shield the skin Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

19.03.2025 21:28 — 👍 66    🔁 27    💬 8    📌 5

Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma Abstract. Immune checkpoint inhibitors (ICI) targeting the PD-1 pathway have transformed treatment of advanced renal cell carcinoma (RCC), but mechanisms underlying therapeutic response remain largely...

1/Excited to share our latest work in Cancer Discovery @theaacr.bsky.social. Led with #MiyaHugaboom and @kstreet.bsky.social, we show that the presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical responses to PD-1 blockade in #RCC: brnw.ch/21wQUU4

25.02.2025 17:45 — 👍 5    🔁 2    💬 1    📌 1