Rainero lab

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration - PubMed Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain l...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration.
pubmed.ncbi.nlm.nih.gov/40669465/

A unified pan-cancer proteome atlas In this issue of Cancer Cell, Knol et al. present the Pan-Cancer Proteome Atlas (TPCPA), a proteomic resource developed using single-shot data-independent acquisition mass spectrometry (DIA-MS). TPCPA...

A unified pan-cancer proteome atlas
www.cell.com/cancer-cell/...

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration - PubMed Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (R...

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.
pubmed.ncbi.nlm.nih.gov/40614209/

On my way to #CRUKAllFellows meeting. Looking forward to it!

Outside influences: The impact of extracellular matrix mechanics on cell migration - PubMed "No cell is an island" - highlights the interconnectedness of cellular behavior and the extracellular matrix (ECM). Cell migration is inherently contextual, as cells navigate and adapt to their enviro...

Outside influences: The impact of extracellular matrix mechanics on cell migration.
pubmed.ncbi.nlm.nih.gov/40571339/

Event carbon calculator - the Node I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your

Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.

thenode.biologists.com/event-carbon...

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!
@mcb-sheffield.bsky.social

Fantastic lab walk with @helenkmatthews.bsky.social ! Thanks to Bian, Rachele and @vichart33.bsky.social for organising

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages Huang et al. demonstrate that the intermediate filaments protein vimentin orchestrates actin stress fibers and podosomes, thereby facilitating efficient extracellular matrix (ECM) degradation via inte...

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages
www.cell.com/developmenta...

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

Sheffield Pancreatic Cancer Research Network Meet the Team

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

We are delighted to host @cassiejclarke.bsky.social
today from the @cruk-si.bsky.social!

"Neutrophil metabolism supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes"

📍 Alfred Denny Conference Room
📅 10th June - 1pm

Our own Alice presenting her MRes poster #biosciences
@mcb-sheffield.bsky.social
@sheffielduni.bsky.social

Image Source: https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00126-8 Figure 1 Key anti- and protumour functions of the extracellular matrix (ECM). Antitumour functions are shown in green and protumour functions are shown in red.

Extracellular matrix plays an important role in #cancer.

"Understanding spatial matrix heterogeneity and its interactions with immune cells is critical for improving immunotherapy responses in matrix-rich cancers, such as pancreatic cancer."
🧪🧬 #Science #Biology #Health
www.cell.com/trends/cance...

Exciting opportunity to join the cancer research community in Sheffield!!

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾
#WeAreInternational
@mcb-sheffield.bsky.social
@sheffielduni.bsky.social

Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

🧵1/6 — Preprint Alert!
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...

Congratulations Bian on passing you PhD viva!!! Thanks to @zech-lab.bsky.social, @helenkmatthews.bsky.social and John for examining
@mcb-sheffield.bsky.social

The Rab25-ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity - PubMed The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a critical role in cancer progression. Focusing on ovarian cancer, Yuan et al. reveal an ECM-dependent signaling ax...

Nice to see our work reviewed in @febsj.bsky.social by @fbaschieri.bsky.social
The Rab25-ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity.
pubmed.ncbi.nlm.nih.gov/40406984/

We are delighted to host @vickysanzmoreno.bsky.social today from the @icr.ac.uk!

"Biomechanical hallmarks and vulnerabilities of metastatic cancer cells"

📍 Alfred Denny Conference Room
📅 4th June - 1pm

@insigneoinstitute.bsky.social
@sheffielduni.bsky.social
@sheffielduni.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination - InFLAMES Research Flagship Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to dete...

In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread.
#Illusia
@ivaskalab.bsky.social

mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this idea by demonstrating that mTO...

mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion
click.notification.elsevier.com/CL0/https:%2...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - PubMed Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized importance of integrin pho...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells.
pubmed.ncbi.nlm.nih.gov/40419795/

Totally agree!! It was an amazing meeting

Latest addition to our Wall of Fame - Rachele 🇮🇹

Amazing talk by Ife at the @mcb-sheffield.bsky.social 2nd year PGR symposium

ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription Abugable et al. investigated the role of ADP-ribosylation in NuMA function during DNA repair. They demonstrate that ADP-ribosylation-deficient NuMA impairs repair kinetics and transcription and fails ...

📣 New paper alert!

The El-khamisy lab uncovered how a key protein, NuMA, helps repair damaged DNA and protect important control regions of our genome, especially after oxidative stress.

🛡️ Protecting the genome = protecting health.
www.cell.com/cell-reports...

I cannot wait for this meeting, it's going to be awesome