Rainero lab

We are delighted to host Harsha Kantamneni today from the University of Bradford.

"Endosomal Sorting Complex Required for Transport (ESCRT): Roles in receptor trafficking, signalling pathways, drug resistance and disease"

📍 Alfred Denny Conference Room

📅 18th October - 1pm

Congratulations to Shahd on passing her PhD viva!!!!
Thanks to Christoph and Jason @jasonkinglab.bsky.social for examining

The integrin odyssey - a journey full of fundamental discoveries - PubMed Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion...

The integrin odyssey - a journey full of fundamental discoveries.
pubmed.ncbi.nlm.nih.gov/40988584/

Great flash talk by Eric at #NECB2025

@breastcancernow.bsky.social
@mcb-sheffield.bsky.social

Sheffield scientists to be a key part of a groundbreaking Yorkshire Cancer Research hub Scientists from the School of Biosciences have received over £580,000 in funding from Yorkshire Cancer Research.

#NPAW2025 #PostdocAppreciationWeek
Rachele is a @yorkshirecancer.bsky.social funded postdoc, investigating the role of the Rab25/ADAMTS5 axis in ovarian and pancreatic cancer peritoneal metastasis.

You can read more about this here:
sheffield.ac.uk/biosciences/...

@mcb-sheffield.bsky.social

Great talk by our own Zhe Bao at the School of Biosciences 3rd year PGR symposium!!
@mcb-sheffield.bsky.social

Investigating mechanisms of breast cancer cell growth and spread Dr Elena Rainero is investigating how breast cancer cells use alternative energy sources to grow and spread, and the role of protein called a2b1 integrin in this.

#NPAW2025 #PostdocAppreciationWeek Eric is a @breastcancernow.bsky.social funded postdoc, investigating the mechanisms of breast cancer cell growth and spread.

You can read more about this here 👇:

breastcancernow.org/our-research...

@mcb-sheffield.bsky.social

#NPAW2025 #PostdocAppreciationWeek Mona is a @cancerresearchuk.org funded postdoc in our lab. She demonstrated that the #ECMatrix supports breast cancer cell growth under starvation by promoting tyrosine catabolism. You can read more about this here:
👇
pubmed.ncbi.nlm.nih.gov/38227562/

Here are our fantastic postdocs: Mona, Rachele & Eric
@mcb-sheffield.bsky.social
#NPAW2025
#PostdocAppreciationWeek

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer Zhang et al. demonstrate that macropinocytosis inhibition induces myCAF-to-iCAF conversion through a metabolically stressed, MEK-ERK-dependent intermediate state. This CAF plasticity remodels the panc...

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

click.notification.elsevier.com/CL0/https:%2...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by low sensitivity for small molecules, limited scalability, and the lack of standardized frameworks for data analysis....

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

Our own Ife will present her PhD work!!

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.27.672673v1

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction

🔗
www.biorxiv.org/content/10.1...

📦
saezlab.github.io/MetaProViz/

🧵 Thread ⬇️

The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge - PubMed The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occu...

The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge.
pubmed.ncbi.nlm.nih.gov/40705420/

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration - PubMed Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain l...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration.
pubmed.ncbi.nlm.nih.gov/40669465/

A unified pan-cancer proteome atlas In this issue of Cancer Cell, Knol et al. present the Pan-Cancer Proteome Atlas (TPCPA), a proteomic resource developed using single-shot data-independent acquisition mass spectrometry (DIA-MS). TPCPA...

A unified pan-cancer proteome atlas
www.cell.com/cancer-cell/...

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration - PubMed Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (R...

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.
pubmed.ncbi.nlm.nih.gov/40614209/

On my way to #CRUKAllFellows meeting. Looking forward to it!

Outside influences: The impact of extracellular matrix mechanics on cell migration - PubMed "No cell is an island" - highlights the interconnectedness of cellular behavior and the extracellular matrix (ECM). Cell migration is inherently contextual, as cells navigate and adapt to their enviro...

Outside influences: The impact of extracellular matrix mechanics on cell migration.
pubmed.ncbi.nlm.nih.gov/40571339/

Event carbon calculator - the Node I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your

Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.

thenode.biologists.com/event-carbon...

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!
@mcb-sheffield.bsky.social

Fantastic lab walk with @helenkmatthews.bsky.social ! Thanks to Bian, Rachele and @vichart33.bsky.social for organising

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages Huang et al. demonstrate that the intermediate filaments protein vimentin orchestrates actin stress fibers and podosomes, thereby facilitating efficient extracellular matrix (ECM) degradation via inte...

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages
www.cell.com/developmenta...

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

Sheffield Pancreatic Cancer Research Network Meet the Team

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

We are delighted to host @cassiejclarke.bsky.social
today from the @cruk-si.bsky.social!

"Neutrophil metabolism supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes"

📍 Alfred Denny Conference Room
📅 10th June - 1pm

Our own Alice presenting her MRes poster #biosciences
@mcb-sheffield.bsky.social
@sheffielduni.bsky.social

Image Source: https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00126-8 Figure 1 Key anti- and protumour functions of the extracellular matrix (ECM). Antitumour functions are shown in green and protumour functions are shown in red.

Extracellular matrix plays an important role in #cancer.

"Understanding spatial matrix heterogeneity and its interactions with immune cells is critical for improving immunotherapy responses in matrix-rich cancers, such as pancreatic cancer."
🧪🧬 #Science #Biology #Health
www.cell.com/trends/cance...

Exciting opportunity to join the cancer research community in Sheffield!!