Jun Allard

Review article with Omer Dushek @tcell.bsky.social on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton

www.annualreviews.org/content/jour...

Many molecular reactions in cells are tethered, often by #IDR. If 2 tethers are tied together (imagine handcuffed arms ⛓️‍💥), does this enhance or suppress their reactions? Formin, one of the major families of #cytoskeleton builders in eukaryotes, does exactly this.

Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly Many proteins contain intrinsically disordered regions (IDRs) that lack stable 3-dimensional structure. IDR behavior is poorly understood, leading to challenges for biochemical and computational analy...

Katie Bogue's new preprint with Margot Quinlan and Bryan Christian, out now!

www.biorxiv.org/content/10.1...

A remarkably simple question, "What is the likelihood landscape for the basic bursting transcription model?", reveals surprisingly complex underlying structure, with implications for the limits of what single-cell data can tell you.

Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data AbstractMotivation. Stochastic gene expression and cell-to-cell heterogeneity have attracted increased interest in recent years, enabled by advances in sin

Very excited to be involved in this new work led by Junhao Gu and Elizabeth Read, out this week in Bioinformatics. Collaboration with Timothy Downing, Chris Miles and others!

academic.oup.com/bioinformati...

We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference!

www.biorxiv.org/content/10.1...

Brady Berg's new work is out on biorxiv! Shows a surprising connection between astral architecture and percolation in the cytoskeleton.

www.biorxiv.org/content/10.1...

An idea is gaining ground that nucleosomes control the genome, via not just local access, but long-range conformation, and not just their density but their specific placement too. Read more!

Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales Abstract. The 3D organization of the genome—in particular, which two regions of DNA are in contact with each other—plays a role in regulating gene expressi

Our paper, lead by Jack Corrette, with Timothy Downing and Andrew Spakowitz is out in Nucleic Acids Research!

academic.oup.com/nar/article/...