The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Holy shit. The new spending package has a hidden provision that allows Republican Senators to sue the government for $500K over the phone records searches related to the January 6 riot. How can any Democrat vote for this? How can you argue this is a good deal?

“We have the highest prices in the world because people who provide health care here can set prices that high. The government doesn’t regulate it nearly as much as they do in other countries.”

Did we get an ACA extension in the bill?

No.

Did we protect Article 2 from Presidential overreach?

No.

Well, what did we get?

Josh Hawley can sue for millions over Jan 6th and they recriminalized hemp products.

Oh sweet...

Remember Tuberville's holds on military appointments?

A single Democratic senator could make things much more difficult for Republicans if they wanted to. But none of them has the appetite for playing hardball. This is part of how we got here. #MEpolitics

A chart showing a 20 year price change between sectors.

Pretty much all affordability discourse could benefit from just posting this chart.

If you're in the better off America, all the luxury goods you want in excess are for the most part much cheaper. If you're in the poorer America, most of the shit you need to live/grow is more expensive.

"The Trump White House, for it's part, is cackling—sometimes literally—about the turn of events. Two White House officials, and two other Trump advisers, could barely contain their giddiness when asked by Zeteo about the latest instance of the Democratic elite capitulating to Trump. Multiple Trump aides and allies kept gratuitously using terms such as "losers" and "pussies" as they revelled in the relief from a shutdown that even President Trump acknowledged was getting Republicans "killed" politically.

scenes from a victory lap

zeteo.com/p/senate-dem...

Chris Murphy: "There will be pretty substantial damage to a Dem brand that has been rehabilitated if on the heels of an election in which the people told us to keep fighting, we immediately stop... if we surrender without having gotten anything, I worry it'll be hard to get them back up off the mat"

Important to understand this. There's a reasonable chance that your Dem Senator who voted against it and is acting mad now was in on the play. It's the same reason why they scheduled the surrender for AFTER the election this week. They didn't want people pissed at Dems right before an election.

Tech Billionaire Marc Andreessen Bet Big on Trump. It’s Paying Off for Silicon Valley. The Trump administration’s gutting of the Consumer Financial Protection Bureau has been good for venture capitalists like Andreessen, who previously accused the agency of “terrorizing” fintech startup...

Three CFPB probes into companies backed by billionaire Marc Andreessen have been halted as bureau investigations have ground to a halt, including inquiries into the popular cash advance app EarnIn and Point Digital Finance, a provider of so-called alternative mortgages.

To everyone mad at Chuck Schumer's leadership and the government shutdown ending w/o protections for healthcare:

The best way to get the GOP to reinstate ACA subsidies?

Win elections. Make them scared.

#TN07 election is in 24 days.

A Dem upset is possible.

Donate. Volunteer. SUPPORT AFTYN BEHN!

The coordinated nature of this—none are facing voters in 2026—means that either Schumer approved it or failed in his job as Senate Majority Leader to stop it.

Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.

reminder to any ambitious Dems waiting in the wings: announcing a primary challenge right now to a squishy Democrat who’s up in 2026, whether they voted tonight to shine Trump’s shoes or not, will almost instantaneously be awash in cash. fortune—and a primary challenge—favors the bold.

The model of holding individual senators responsible is broken here. The retirees clearly agreed to take the fall. Which is why the nos should get no credit for voting no unless they move to oust Schumer

I think Senate folders are significantly underestimating how fucking angry Democratic voters are at them

Assume all the yes and no votes from Dem senators are strategic and not sincere votes. The party caucus made a decision. No way to know how many were in favor. Then the caucus decided who would vote yes and no based on what would protect each of them politically the most. That’s how this works.

Why nearly all of them up for reelection next year deserve primaries anyway:

Well now, would you look at that?

A massive study of NEARLY 300,000 people in the United States found that receiving an updated 2024-2025 mRNA COVID-19 vaccine REDUCED people’s risk of severe disease AND death in ALL age groups, REGARDLESS of immunity from prior infection or vaccination.

In Finland, charging fees for school tuition is illegal, which means rich kids have to mix with normal kids.
That means rich families had to make sure the schools their children attended were good, which in turn prompted the wealthy to invest in public education.

Finland, take a bow.

Mainstream media is now mainly leaning right Most traditional media have long held a more left-leaning tone, but that’s changing.� From on the ground reporting to the ...

Larry Ellison. Jeff Bezos. Rupert Murdoch. One by one, billionaires tied to Trump are snapping up media outlets and pushing them rightward. The goal isn’t truth—it’s control.

Article image

Democrats are making a big push for @aftynbehn.bsky.social for the #TN07 Special Election, where early voting begins on November 12th.

We have to keep spreading the word here.

www.tennessean.com/story/news/p...

Why Does Schumer Keep Trying to Cave? - The American Prospect Most commentators, including me, concluded that the Tuesday election victory saved Democrats from capitulating to Republican demands to pass a simple continuing resolution to re-open the government, i...

Reporting from @ddayen.bsky.social says Schumer almost orchestrated a team of Democrats to concede to Republicans without any hard commitments. Then his caucus, including some members of a supposed working group, balked.
prospect.org/2025/11/08/w...

Minutes after MAGA congresswoman Elise Stefanik announced her candidacy for #NYGov, a Team Hochul Twitter account for @governor.ny.gov posted this ad.

And boy, it's savage!

But also, if the ad airs on TV, it'll boost Stefanik's chances in a GOP primary.

Hochul wants to face her. #NewYork #NYpol

Flooded UK coalmines could provide low-carbon cheap heat ‘for generations’ Report says proven technology could benefit thousands in poor quality housing and help UK meet carbon reduction targets Flooded disused coalmines could be a significant source of energy and provide cheap heat to thousands of homes, a new report argues. Mine water geothermal heat (MWGH) systems use the water in flooded coalmines, which is warmed by natural processes, to supply low-carbon heat. Heat exchangers and pumps recover the heat, which is distributed via district heating networks to homes and buildings, providing low-cost, long-term, stable energy. Continue reading...

Flooded UK coalmines could provide low-carbon cheap heat ‘for generations’

Rs want it both ways. They want to mock Democrats and excuse whatever Trump says about them. Senators laugh if you ask about Trump's AI posts - he's just trolling, lol!

They also want any crazy or offensive thing *Dems* say to be a horrifying violence-inspiring threat. Can't have both. (2/2)

If I was a GOP strategist, I’d be pretty worried about diluting my safe +15 districts into a bunch of +5 gerrymandered districts after tonight.

2 0 2 5 Updates Key Races N.Y.C. Mayor Va. Gov. County Margin Shift from 2024 pres. T Votes Loudoun Spanberger +29 * 12 pts. 164,366 Prince William Spanberger +34 × 16 pts. 161,419 Portsmouth Spanberger +47 * 8.1 pts. 29,956 Washington Earle-Sears +49 * 4.5 pts. 20,927 Louisa Earle-Sears +20 * 6.5 pts. 18,719 Orange Earle-Sears +15 * 9.3 pts. 17,127 Powhatan Earle-Sears +40 * 4.4 pts. 16,957 Pulaski Earle-Sears +38 * 7.1 pts. 12,466 Dinwiddie Earle-Sears +17 ~ 6.3 pts. 11,974 Harrisonburg Spanberger +41 × 15 pts. 11,753 Manassas Spanberger +30 * 16 pts. 11,514 Carroll Earle-Sears +57 ~ 6.1 pts. 11,277 Wise Earle-Sears +59 ~ 4.6 pts. 10,962 Fairfax City Spanberger +45 * 11 pts. 10,232 Fredericksburg Spanberger +43 * 11 pts. 10,191 Salem Earle-Sears +12 6.9 pts. 9,374 King William Earle-Sears +34 * 7.1 pts. 8,999 Russell Earle-Sears +63 * 4.9 pts. 8,860

Every single county in Virginia shifted Blue.

Meanwhile in California — this is the line at LMU of young people waiting to vote for PROP 50 to balance out Trump’s seat-stealing in Texas.

#CaliforniaClapback

https://cardinalnews.org/2025/11/04/election-live-updates-and-analysis-of-virginias-2025-election/ "This isn’t good news for Del. Chris Obenshain, R-Montgomery County, who faces a rematch with Democrat Lily Franklin. I used the turnout numbers that Chaz Nuttycombe of State Navigate has posted. In Montgomery County precincts that Franklin won two years, turnout is at 67.5% of presidential levels last year. But in the precincts that Obenshain won, they’re at 62% of last year’s presidential turnout. Obenshain needs a late surge of voters in Montgomery."

Encouraging news for Democrat Lily Franklin; conversely, bad news for incumbent Republican Del. Chris Obenshain bluevirginia.us/2025/11/virg... h/t @CardinalNewsVA

Looks like GOP has problems across Southwest Virginia

No other competitive House of delegates races, but could have big implications for Attorney General race