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Center for Cancer Immunotherapy and Immunobiology

@ccii-kyoto.bsky.social

Conquering cancer by advancing immunotherapy. The CCII is a research center at Kyoto University, led by Nobel Laureate Prof Tasuku Honjo. https://www.ccii.med.kyoto-u.ac.jp/en/

811 Followers  |  717 Following  |  69 Posts  |  Joined: 30.01.2025  |  2.1674

Latest posts by ccii-kyoto.bsky.social on Bluesky

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๐ŸŒŸEFIS & EJI launch the #ECR Article of the Year Prize

๐Ÿ†โ‚ฌ5,000 for the best research article in EJI
๐ŸŒOpen to ECRs worldwide - 10 yrs post-PhD or post-MD (extensions apply)
๐Ÿ–Š๏ธMust be first or senior corresponding author
๐ŸŽคWinner will present at ECI + receive a travel grant to attend
โ„น๏ธCheck the QR code๐Ÿ‘‡

11.11.2025 07:27 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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CCII Vice Director Sidonia Fagarasan introducing Michael Dustin (Oxford), who gave a great talk on the immunological synapse.
For a list of upcoming seminars & events at CCII, visit our webpage.
#Immunology #Immunotherapy

www.ccii.med.kyoto-u.ac.jp/en/events/

11.11.2025 09:13 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Discovery and development of an oral analgesic targeting the ฮฑ2B adrenoceptor | PNAS Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...

A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a ฮฑ2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...

22.08.2025 01:03 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.

The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece ๐Ÿ‘‡

www.cell.com/current-biol...

04.09.2025 00:35 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues

03.09.2025 23:02 โ€” ๐Ÿ‘ 7    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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To find out more about research in the Hagiwara group at CCII, click on ๐Ÿ‘‡
www.ccii.med.kyoto-u.ac.jp/en/research/...

22.08.2025 01:04 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.

The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece ๐Ÿ‘‡

www.cell.com/current-biol...

04.09.2025 00:35 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues

03.09.2025 23:02 โ€” ๐Ÿ‘ 7    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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To find out more about research in the Hagiwara group at CCII, click on ๐Ÿ‘‡
www.ccii.med.kyoto-u.ac.jp/en/research/...

22.08.2025 01:04 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Discovery and development of an oral analgesic targeting the ฮฑ2B adrenoceptor | PNAS Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...

A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a ฮฑ2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...

22.08.2025 01:03 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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To find out more about research in the Hagiwara group at CCII, click on ๐Ÿ‘‡

www.ccii.med.kyoto-u.ac.jp/en/research/...

22.08.2025 01:01 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

โ€œI have a friend who told me: โ€œThis is my last round in my life because I have lung cancerโ€. But half a year later he came back and had just started the treatment we developed, and he was just completely cured.โ€

Tasuku Honjo (1942- )
NobelPrize in Medicine 2018

06.02.2025 13:52 โ€” ๐Ÿ‘ 14    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Center for Cancer Immunotherapy and Immunobiology ไบฌ้ƒฝๅคงๅญฆๅคงๅญฆ้™ขๅŒปๅญฆ็ ”็ฉถ็ง‘้™„ๅฑž ใŒใ‚“ๅ…็–ซ็ทๅˆ็ ”็ฉถใ‚ปใƒณใ‚ฟใƒผ๏ผˆCenter for Cancer Immunotherapy and Immunobiology๏ผˆCCII๏ผ‰๏ผ‰ใฏใ€2020ๅนด4ๆœˆ1ๆ—ฅใซ้–‹่จญใ•ใ‚Œใพใ—ใŸใ€‚ ใ“ใฎใ‚ปใƒณใ‚ฟใƒผใงใฏใ€ใ€ŒใŒใ‚“ใฎๅพๅœงใ€ใจใ„ใ†ๅคงใใชๅคขใซๅ‘ใ‹ใฃใฆ้›†ใ†ไธ–็•Œๅ„ๅ›ฝใ‹ใ‚‰้›†ใพใฃใŸ็ ”็ฉถ่€…ใŒๆดป็™บใช็ ”็ฉถใ‚’่กŒใ„ใพใ™ใ€‚

The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.

Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/

28.07.2025 15:21 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Continuous cultures of fused cells secreting antibody of predefined specificity - Nature Nature - Continuous cultures of fused cells secreting antibody of predefined specificity

Happy 50th birthday to monoclonal antibodies! While researching antibody diversity, Kรถhler and Milstein developed a technique for generating large amounts of monoclonal antibodies: www.nature.com/articles/256... #immunosky #immunology

07.08.2025 15:47 โ€” ๐Ÿ‘ 16    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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๐Ÿ—“๏ธ Mark your calendars โ€“ #IMMUNOLOGY2026โ„ข abstract submissions open on September 3! Get ready to share your latest research with the global immunology community. ow.ly/ekqM50WBK9q

#immunology #scicomm

11.08.2025 13:28 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Common origins of autoimmune diseases and lymphoid malignancies Interactions between autoimmune disorders and lymphoid malignancies have long been recognized; for instance, with prominent autoimmune manifestations in B- and T-cell lymphomas and an increased risk of lymphoma development in individuals with autoimmune diseases. More recently, several lines of evidence have shown that these two disease types have shared origins, defined by common genetic lesions and pathogenic cell states. Recent work suggests that the safeguards that protect normal lymphocyte development and adaptive immunity against the development of autoimmune diseases and lymphoid malignancies are based on similar sensing mechanisms of pathological lymphocytes. Here, we propose that mechanisms of negative selection that are designed to eliminate autoreactive lymphocytes also operate in suppressing the development of lymphoid malignancies.

Common origins of autoimmune diseases and lymphoid malignancies #immunology

14.08.2025 23:15 โ€” ๐Ÿ‘ 9    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

A great talk โ€” Hiroshi has just arrived back in Japan after a postdoc in Ron Germain's lab & he showed some beautiful 3D high rez images. The paper is not out yet, but watch this space

20.08.2025 00:15 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Hey everybody! @drjuliawester.bsky.social and I have a new paper!

We surveyed over 800 scientists, science communicators, and science educators who use social media.

Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! ๐Ÿงช๐ŸŒŽ๐Ÿฆ‘

doi.org/10.1093/icb/...

19.08.2025 14:34 โ€” ๐Ÿ‘ 3812    ๐Ÿ” 1194    ๐Ÿ’ฌ 88    ๐Ÿ“Œ 111
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Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...

20.08.2025 00:04 โ€” ๐Ÿ‘ 7    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Tomorrow (Tuesday) at CCII, Hiroshi Ichise on
โ€œHighly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lungโ€
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/

18.08.2025 02:05 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Preview: IASLC | ASCO 2025 North American Conference on Lung Cancer | IASLC Join Dr. Stephen Liu on Lung Cancer Considered as he sits down with two co-chairs of the upcoming IASLC | ASCO 2025 North American Conference on Lung Cancer (NA ...

#NACLC25 is open! Registration & abstracts are live for Dec 5โ€“7, 2025, in Chicago.

Hear from coโ€‘chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Consideredโ€”insights, highlights & why you should be there.

๐ŸŽง bit.ly/NACLC25Preview

#LungCancer @ascocancer.bsky.social

25.07.2025 22:24 โ€” ๐Ÿ‘ 3    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Center for Cancer Immunotherapy and Immunobiology ไบฌ้ƒฝๅคงๅญฆๅคงๅญฆ้™ขๅŒปๅญฆ็ ”็ฉถ็ง‘้™„ๅฑž ใŒใ‚“ๅ…็–ซ็ทๅˆ็ ”็ฉถใ‚ปใƒณใ‚ฟใƒผ๏ผˆCenter for Cancer Immunotherapy and Immunobiology๏ผˆCCII๏ผ‰๏ผ‰ใฏใ€2020ๅนด4ๆœˆ1ๆ—ฅใซ้–‹่จญใ•ใ‚Œใพใ—ใŸใ€‚ ใ“ใฎใ‚ปใƒณใ‚ฟใƒผใงใฏใ€ใ€ŒใŒใ‚“ใฎๅพๅœงใ€ใจใ„ใ†ๅคงใใชๅคขใซๅ‘ใ‹ใฃใฆ้›†ใ†ไธ–็•Œๅ„ๅ›ฝใ‹ใ‚‰้›†ใพใฃใŸ็ ”็ฉถ่€…ใŒๆดป็™บใช็ ”็ฉถใ‚’่กŒใ„ใพใ™ใ€‚

The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.

Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/

28.07.2025 15:21 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Kinase gene alterations in cancer

Kinase gene alterations in cancer

For readers interested in anticancer drugs, this Review in the July issue discusses progress and challenges in the development of tumour-agnostic kinase inhibitors
www.nature.com/articles/s41...
rdcu.be/eybm4

28.07.2025 14:44 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiomeโ€ this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...

24.07.2025 09:06 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

ICYMI

24.07.2025 09:32 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

ICYMI

24.07.2025 09:32 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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An unforgettable week of science and collaboration in Kyoto! ๐Ÿ”ฌ A huge thank you to the brilliant Sidonia Fฤƒgฤƒrฤƒศ™an and her entire lab for hosting me at the Center for Cancer Immunotherapy and Immunobiology (CCII).

Looking forward to future collaborations!

06.07.2025 14:51 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Jianguo (Jeff) Xia Image by Alex Tran. Professor - Large Data Analysis Canada Research Chair (Tier 2) Bioinformatics and Big Data Analytics (Cross-appointed with the Department of Animal Science) T: 514-398-8668 |...

Dr Xia's lab at McGill works on "understanding important biological, environmental and nutritional factors on health and disease; developing computational solutions for high-throughput experiments."
www.mcgill.ca/parasitology...

24.07.2025 09:10 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiomeโ€ this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...

24.07.2025 09:06 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler

Tons of open slots, invited and selected speakers all get 20 mins โค๏ธ

#EESNucleus

23.07.2025 10:49 โ€” ๐Ÿ‘ 58    ๐Ÿ” 34    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2

@ccii-kyoto is following 20 prominent accounts