Erez Yirmiya

Beautiful work Jeremy, It's exciting to see it out. Congrats!

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

📢 New preprint alert!
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵

Congrats @romihadary.bsky.social and @reneechang.bsky.social for dissecting the functional diversity of ALL Sponges! 🧽

An absolute masterpiece by the talented @dinahoch.bsky.social on nucleotide-based immunity

Amazing work identifying novel immune inhibitors based on structural and genomic traits.
Congrats Nitzan and everyone!

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

Thanks Changwei!

Thank you Marcin 🙏🏻

This was our latest journal-club paper. Nice use of large-scale AlphaFold modelling & various experiments. Phage proteins’ ability to recognise eukaryotic homologues of their bacterial targets is striking - suggests these proteins evolved to recognise their targets in a fairly mutation-resistnt way.

A conserved chaperone protein is required for the formation of a non-canonical type VI secretion system spike tip complex Type VI secretion systems (T6SS) are dynamic protein nanomachines found in Gram-negative bacteria that deliver toxic effector proteins into target cells in a contact-dependent manner. Prior to secreti...

A fun collaboration with the Whitney, Prehna, and Bosis labs, in which we reveal the role of DUF2169 proteins: assisting PAAR-like domains in forming spike complexes and #T6SS assembly. 🦠

search.app/jDxaUi5yJK9B...

Thanks Dina! Always fun to work together 🤩

Check out our latest paper using protein structures to uncover immune inhibitors hidden among millions of phage genes! These inhibitors block immune proteins from bacteria, plants and even humans, highlighting how immunity and counter-immunity mechanisms are conserved across the tree of life! 🦠🌿🧍‍♀️

Thanks Aude!! 🙏

Incredbile work from @soreklab.bsky.social demonstrating how to mine viral genomes to identify immune-modulatory proteins that work across bacteria, plants and animals 😱.

Bacteria have been amazing ressources of molecular diversity for biotech and medicine, now viral diversity can be explored too!

Thank you Nonia! 🙏🙏

Really cool!
Remarkable that phage proteins can inhibit human and plant TIR proteins and human cGAS. Conservation of function across such long evolutionary distances identifies new immunomodulators

Congrats to @soreklab.bsky.social and Kranzusch labs! What a great collaboration that is 😍

🧪

Thanks Sadie! 🙏🤩

Viral immune evasion proteins are widespread and block both bacterial and human immune proteins! Go check out Erez’s paper using AlphaFold-multimer to screen for new anti-defense proteins!!🤩🤩

Thank you Ben! 🙏

Been waiting a long time to see this in print - phage proteins are capable of inhibiting immune systems across host-domain boundaries 🤯

Big congrats @erezyirmiya.bsky.social et al!!

Thank you Avigail! 🙏

I'm excited to see the published version of this amazing work.

@erezyirmiya et al identified viral proteins that inhibit host immunity using structural predictions of protein-protein interactions.

Congrats to you all @soreklab & Kranzusch lab! 🥂

Thanks Jens!

Thank you Francois! (:

A high-throughput AlphaFold screen reveals phage proteins that bind and inhibit bacterial immune proteins 🤯 Some of them even bind and inhibit eukaryotic immune proteins as well !

Congrats @erezyirmiya.bsky.social @soreklab.bsky.social et al for these beautiful discoveries 👌

Thanks Adrian 🙏

Thank you Joe 🙏

Thank you Luuk!

Thanks Basile!