Fabian Zimmermann

My final postdoctoral work will come out very soon, so watch this space 🧐.

In Amsterdam, I aim to decipher the molecular mechanisms of (cancer)-cell migration and adhesion using structural biology approaches. Positions available soon, so please reach out when you are interested! 😁

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

Molecular requirements for PLK1 activation by T-loop phosphorylation Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...

www.biorxiv.org/content/10.1...

Frank Stahl, screen capture from: https://youtu.be/7-tnuAqEp9g

RIP Franklin W. Stahl (1929–2025)

here is Frank explaining semiconservative replication of DNA in the marvelous interview from 2020 together with Matt Meselson (youtu.be/7-tnuAqEp9g)

I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction?

Web server: alpha-bridge.eu

Preprint: www.biorxiv.org/content/10.1...

New features coming soon!

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection!

institute-genetics-cancer.ed.ac.uk/igc-graduate...

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196 Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial-A dream and a bit of a nightmare

Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.

7️⃣1️⃣ Jean Marian Purdy (1945-1985) 🇬🇧 #womeninSTEM Pioneer of fertility treatment. On 25/07/1978, the world learned of the birth of the 1st IVF baby: Louise Brown. Jean Purdy was part of the team that contributed to this success, but her name has been forgotten.

pmc.ncbi.nlm.nih.gov/articles/PMC...

Very sad news today… Joan was director when I joined @IRBBarcelona.org and I owe him this great opportunity. He has led us to become not only a place for excellent science, but also a warm, friendly and collegial environment, a rare combination. We continue in Joan’s spirit, he will be missed!

Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.

Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.

www.cell.com/developmenta...

En respuesta a las recientes declaraciones antievolucionistas de Jaime Mayor Oreja, desde la Junta Directiva de la SESBE
hemos escrito esta carta abierta. #evolución

👇
drive.google.com/file/d/10p_4...

How did we get here, with a prominent anti-vaxxer nominated to lead Health and Human Services, with its $1.7T budget?

Much of it can be traced to this retracted 1998 paper, falsely linking the measles, mumps and rubella (MMR) vaccine to autism. 1/3

It was Tony Crowther whose advice I still hold dearly: "Don't worry about the journal, it will still be the same science you are publishing somewhere else."

I gladly bring this meeting to your attention so that you can mark dates in your calendar in case your are interest. Additional information will follow. Please circulate if possible.

Exploring structural diversity across the protein universe with The Encyclopedia of Domains The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and ...

Hi TED! 👋
Out now in Science, we are finally ready to make our classification of all domains in AFDB v4 available to all!
A joint effort of @cathgene3d.bsky.social and the Jones group (PSIPRED), here's a link to the article

www.science.org/doi/10.1126/...

1/6 🧵⤵️

iBiology is a REMARKABLE and under-utilized resource for learning from some of the pioneers of microscopy--these videos are suitable for undergraduate classes or experts 🧪