Nicholas William Ashton

Re-submitted manuscript awaiting decision *deep breaths*

Big day. Submitted a grant application in the morning - my fifth of the year 😵‍💫 - and resubmitted a paper in the evening

Two futures for academic publishing using artificial intelligence language tools. Information communicated in English is shown in pale blue and that in a language other than English (Japanese in this example) is shown in orange.

Can we imagine a future in which everyone can use their own language to write, assess & read science with the help of AI? Read this to see why we believe this is the future of academic publishing. Great collab with @bowkerl.bsky.social & Andrew Burton-Jones. #languagebarriers
doi.org/10.1371/jour...

USP1 inhibition: A journey from target discovery to clinical translation Ubiquitin-specific protease 1 (USP1) is a deubiquitinating enzyme involved in the DNA damage response. Upon DNA damage, USP1 stabilizes replication fo…

Pleased to share a new review article of ours on USP1 inhibitors. Thank you to Carlos Torrado and Tim Yap for inviting us to contribute

www.sciencedirect.com/science/arti...

Also, check out this excellent review on a similar topic from @hw1o9.bsky.social

www.sciencedirect.com/science/arti...

Presented a poster today at a Dana-Farber symposium. I was asked by three people whether I am a PhD student. Glad to know I haven’t outwardly aged too much over the past decade.

According to the Office of Research Integrity, most drivers of research misconduct are due to work and/or life pressures. What a shock.

We are getting some good data!

Something amazing has happened at work. The building maintenance team has emptied and cleaned the fridges in our break room. The first time in living memory. And from now on they will be emptied once per month.

Today, the technician I am supervising said to me, in relation to our project, 'you know, this is actually pretty cool'. It made my day.

I am proud to share that after several years of on-again, off-again effort, I have finally finished Marcel Proust's 'In Search of Lost Time' (translation by Moncrieff and Kilmartin). It was one of the most incredible novels I have read, as well as one of the most difficult.

Welcome to DFCI!

I wish I had a better plan. As they say, your only job as a postdoc is to get another job. But the time quickly gets away from you.

Hello, great list, thank you. Can you please include me?

Today I assembled a new UV-C irradiation system. Parts include: a handheld UV lamp, a cardboard box, a polystyrene box, a piece of plywood, a step-up transformer and a UV dose metre. Stable output of 40 uW/cm2

Three days later and I can walk up and down stairs again.

DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation DNA polymerase eta (Pol η) is a Y-family translesion polymerase responsible for synthesizing new DNA across UV-damaged templates. It is recruited to replication forks following mono-ubiquitination of ...

I am pleased to share our latest preprint. In this work we show that the ubiquitin-binding domain of Pol eta interacts with NEDD8, and that this interaction is required for Pol eta mono-NEDDylation. Looking forward to having this work published-published. www.biorxiv.org/content/10.1...