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Mueller Lab (KCL)

@mueller-lab-kcl.bsky.social

Chemical Biology Lab - Interests in Protein Chemistry; Post-translational modifications, especially those that occur on the polypeptide backbone; p53 signalling; molecular ageing.

119 Followers  |  97 Following  |  2 Posts  |  Joined: 03.01.2025  |  1.387

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We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity in vitro. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.

03.02.2025 22:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the Ξ²-linked isomer l-isoaspartic acid (isoAsp) from as...

Thrilled to announce our group's latest paper in JACS by co-1st Authors Tianze Zhang (now at Crick) & Luis Guerra; great collaboration with Yana Berlina, Beat Fierz (EPFL) and Jon Wilson (Crick): doi.org/10.1021/jacs...

03.02.2025 22:14 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

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