CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
I’m excited to share our new paper published in #Sience #Immunology ! We show that CLNS1A is essential for #CD4 #TCell and #Autoimmunity
CLNS1A interacts with PRMT5 and functions as an essential epigenetic regulator of DNA damage response machinerie and T cell proliferation
@stefanfeske.bsky.social
17.07.2025 15:27 — 👍 3 🔁 0 💬 0 📌 0
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!
20.06.2025 18:34 — 👍 20 🔁 5 💬 0 📌 0
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells @sciimmunology.bsky.social @NoyerLucile @stefanfeske.bsky.social
www.science.org/doi/10.1126/...
20.06.2025 18:56 — 👍 2 🔁 1 💬 0 📌 0
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