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altmeyerlab

@altmeyerlab.bsky.social

Genome integrity maintenance during cell cycle progression: This is what we care about, this is what we study. #GenomeStability #ReplicationStress #DNADamage #UZH #Science #AcademicSky https://www.altmeyerlab.org/

788 Followers  |  308 Following  |  7 Posts  |  Joined: 09.11.2024  |  2.1026

Latest posts by altmeyerlab.bsky.social on Bluesky

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A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...

02.10.2025 18:47 β€” πŸ‘ 24    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
A screenshot of a post by the Jane Goodall Institute on LinkedIn stating that they learned that Dr. Goodall passed away due to natural causes in California while on her speaking to her current speaking tour there.

A screenshot of a post by the Jane Goodall Institute on LinkedIn stating that they learned that Dr. Goodall passed away due to natural causes in California while on her speaking to her current speaking tour there.

The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.

01.10.2025 18:01 β€” πŸ‘ 1607    πŸ” 476    πŸ’¬ 37    πŸ“Œ 63
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Professors x 10, Faculty of Medicine & Dentistry | Veredus QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

01.10.2025 07:34 β€” πŸ‘ 19    πŸ” 9    πŸ’¬ 1    πŸ“Œ 1
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Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

18.09.2025 16:09 β€” πŸ‘ 70    πŸ” 21    πŸ’¬ 3    πŸ“Œ 4
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Congratulations to Dirk GΓΆrlich and Steven L. McKnight, 2025 #LaskerAward winners! - β€œfor discoveries that exposed the structures and functions of low-complexity domains within protein sequences” πŸ§ͺ
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

11.09.2025 13:07 β€” πŸ‘ 25    πŸ” 13    πŸ’¬ 0    πŸ“Œ 6
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DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: β€œDNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

03.09.2025 15:59 β€” πŸ‘ 39    πŸ” 19    πŸ’¬ 7    πŸ“Œ 1
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πŸ“’Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➑️https://bit.ly/3JJzYR4

02.09.2025 14:34 β€” πŸ‘ 0    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

@efapostolou29.bsky.social @thecesarelab.bsky.social we're looking forward to your presentations at this fantastic meeting!

02.09.2025 14:35 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Image of Toronto

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

28.08.2025 06:34 β€” πŸ‘ 129    πŸ” 167    πŸ’¬ 0    πŸ“Œ 7
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Deadline approaching for #SGO25

πŸ—“ 31 Oct – 03 Nov 2025
πŸ“Riviera Maya, Mexico

Poster & Reg deadline: 01 Sept 2025
Details & Reg: bit.ly/45Mmhtv

$250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.

27.08.2025 11:39 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicineβ€”Basic Sciences

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...

14.08.2025 16:57 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Another exciting research article from a member of the #RepliFate network!

The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.

Check out their findings here: doi.org/10.1016/j.ce...

11.08.2025 09:26 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates

31.07.2025 14:09 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Nanoscale 3D DNA tracing in non-denatured cellsΒ resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!

www.nature.com/articles/s41...

Congratulations to Kai and Oyvind!!

21.07.2025 10:53 β€” πŸ‘ 64    πŸ” 27    πŸ’¬ 1    πŸ“Œ 0
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πŸ“£ We are recruiting new group leaders in Innovative Biology!

RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology

Application and information ⬇️
application.igmm.cnrs.fr

@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

28.05.2025 12:12 β€” πŸ‘ 36    πŸ” 53    πŸ’¬ 3    πŸ“Œ 2
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New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...

21.05.2025 17:17 β€” πŸ‘ 228    πŸ” 45    πŸ’¬ 3    πŸ“Œ 3
Under the microscope: DNA damage tracked through cell generations | Nature An ingenious technique reveals how stressed cells divide to produce progeny that have different traits β€” a phenomenon that can initiate cancer. An ingenious technique reveals how stressed cells divide to produce progeny that have different traits β€” a phenomenon that can initiate cancer.

πŸ”¬Under the microscope: DNA damage tracked through cell generationsπŸ”¬

It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com

rdcu.be/em0qi

@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social

21.05.2025 15:56 β€” πŸ‘ 20    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

21.05.2025 15:57 β€” πŸ‘ 43    πŸ” 11    πŸ’¬ 0    πŸ“Œ 3
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2nd Spatial Genome Organisation Conference | Fusion Conferences Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i

15.05.2025 12:25 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply by May 18: imba.science/beagroupleader #hiring #biology #research #groupleader #europe

14.05.2025 07:00 β€” πŸ‘ 15    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1
Poster with DGZ 2025 Meeting details (speakers list, organizers, sponsors)

Poster with DGZ 2025 Meeting details (speakers list, organizers, sponsors)

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

08.04.2025 10:51 β€” πŸ‘ 28    πŸ” 14    πŸ’¬ 1    πŸ“Œ 5
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We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

07.04.2025 13:01 β€” πŸ‘ 68    πŸ” 27    πŸ’¬ 1    πŸ“Œ 2

Interested in these or related topics and looking for (or know somebody looking for) a PhD position? We have openings and an approaching application deadline @lifesciencezurich.bsky.social: www.lifescience-graduateschool.uzh.ch/en.html. Please repost. #PhDLife #LifeScience #Switzerland

27.03.2025 15:13 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.

25.03.2025 15:49 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 1    πŸ“Œ 1

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!

Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🀩

www.sciencedirect.com/science/arti...

24.03.2025 15:29 β€” πŸ‘ 74    πŸ” 40    πŸ’¬ 1    πŸ“Œ 1
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Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de GΓ©nΓ©tique et de Biologie MolΓ©culaire et Cellulaire) | 12837602 The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

Come start your lab in beautiful Strasbourg πŸ‡«πŸ‡· www.nature.com/naturecareer...

22.03.2025 13:50 β€” πŸ‘ 35    πŸ” 29    πŸ’¬ 1    πŸ“Œ 0
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PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.

www.biorxiv.org/content/10.1...

Brief teaser:

20.03.2025 08:08 β€” πŸ‘ 38    πŸ” 21    πŸ’¬ 3    πŸ“Œ 1
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Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

18.03.2025 16:32 β€” πŸ‘ 67    πŸ” 22    πŸ’¬ 1    πŸ“Œ 1
Image handling using Fiji - training materials Description:This training package provides a guide to image processing and analysis using ImageJ/Fiji, an open-source software widely used in biological and medical imaging. The manual includes step-b...

I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training

30.01.2025 15:10 β€” πŸ‘ 165    πŸ” 62    πŸ’¬ 5    πŸ“Œ 0
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Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196 Research Group Leader Tenure Track Starting Salary Β£65,940 to Β£74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! πŸ₯³
Re-posts appreciated.

www.nature.com/naturecareer...

27.01.2025 09:38 β€” πŸ‘ 73    πŸ” 71    πŸ’¬ 1    πŸ“Œ 4

@altmeyerlab is following 20 prominent accounts