altmeyerlab

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!

www.nature.com/articles/s41...

Congratulations to Kai and Oyvind!!

📣 We are recruiting new group leaders in Innovative Biology!

RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology

Application and information ⬇️
application.igmm.cnrs.fr

@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...

🔬Under the microscope: DNA damage tracked through cell generations🔬

It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com

rdcu.be/em0qi

@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

2nd Spatial Genome Organisation Conference | Fusion Conferences Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply by May 18: imba.science/beagroupleader #hiring #biology #research #groupleader #europe

Poster with DGZ 2025 Meeting details (speakers list, organizers, sponsors)

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

Interested in these or related topics and looking for (or know somebody looking for) a PhD position? We have openings and an approaching application deadline @lifesciencezurich.bsky.social: www.lifescience-graduateschool.uzh.ch/en.html. Please repost. #PhDLife #LifeScience #Switzerland

1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!

Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩

www.sciencedirect.com/science/arti...

Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602 The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...

PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.

www.biorxiv.org/content/10.1...

Brief teaser:

Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196 Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today:
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!

www.sciencedirect.com/science/arti...

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Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!

You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond

Registration will open by June 2025/

University Professor of Life History Evolution W3 - Johannes Gutenberg-Universität Mainz Johannes Gutenberg-Universität Mainz looks for University Professor of Life History Evolution W3 in Mainz - apply now!

www.academics.com/jobs/univers...

Please help us find a new colleague at Mainz University. Thanks!
#evolbiol

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Programme Leader Track - MRC Laboratory of Medical Sciences Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.

@mrc-lms.bsky.social is hiring! Are you looking to start your own research group? Come & join us!

Fantastic research, wonderful facilities & super supportive colleagues. Deadline 13th Jan.

Get on it!

lms.mrc.ac.uk/work/vacanci...

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

I guess I told you about the fact that SMC proteins like cohesin and condensin are a novel class of molecular motors that make loops into DNA (something we visualized first in 2018). These DNA loops are the fundamental motif that organize our chromosomes.

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Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA and protecting genome integrity, forms filamen...

www.science.org/doi/10.1126/...

And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬

More details via www.imb.de/jobs
Application deadline is 5 January 2025

#sciencejobs #resilience #biostatistics

Group leader positions at the IMP | Research Institute of Molecular Pathology

i might be biased, but this place is amazing: great colleagues, vibrant campus, brilliant students/postdocs - and Vienna! perfect for starting an ambitious project. apply now for a GL position at the IMP …

www.imp.ac.at/career/open-...

EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...