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✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

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RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Congrats to Koichi Sato and @puckknipscheer.bsky.social on this beautiful paper! The biochemistry is 🤯 Happy to help with scEdUseq to pinpoint the DNA replication defects! 🎉🧬

RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...

Knot good: How cells untie DNA to protect the genome New work from the Knipscheer group reveals a mechanism involving RNA and DNA repair proteins that helps cells safely remove G-quadruplex (G4) structures.

New work from the Knipscheer group published in @science.org reveals a mechanism involving RNA and DNA repair proteins that helps cells remove G-quadruplex structures. G4 structures are knot-like formations in DNA that can cause damage if left unresolved. www.hubrecht.eu/cells-untie-dna-knots/

As the Science editor @dijiang319.bsky.social nicely worded: “This reveals a role for RNA transcripts in restoring genome architecture and maintaining its integrity and function”. Big thanks to all Knipscheer lab members, @hubrechtinstitute.bsky.social, and @oncodeinstitute.bsky.social (4/4)

Inhibition of this mechanism causes global G4 and R-loop accumulation, leading to transcription dysregulation, replication stress, and genome instability. Thanks to cells from @joost84.bsky.social from the Tijsterman lab and amazing scEdUseq by @jervdberg.bsky.social from the Oudenaarden lab (3/4)

We found G4s are recognized as DNA lesions leading to homology-directed invasion of RNA opposite the G4 to form a G-loop structure. This G-loop initiates G4 unwinding by DHX36 and FANCJ. Subsequent nucleolytic incision followed by renewal of the RNA-containing strand drive G-loop disassembly (2/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

Hi Erik, i am a group leader at the Hubrecht Institute and I would like to be added to the feed. Here is the link to my lab website: www.hubrecht.eu/research-gro...

I totally agree Helen, trying to solve a problem actually makes it worse.

Another day another review request (10 days). With the usual ‘suggest alternatives from underrepresented communities’. This approach doesn’t just overburden the underrepresented groups, it under-burdens the overrepresented ones, freeing them up to do stuff that is ‘objectively’ judged as ‘better’.

@puckknipscheer.bsky.social, @luijsterburglab.bsky.social, @marcelvanvugt.bsky.social, @sylvie-noordermeer.bsky.social, @titiasixma.bsky.social, @marcelvanvugt.bsky.social, @marteijnlab.bsky.social

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!

You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond

Registration will open by June 2025/