Thomas Pradeu

PPP2R1A mutations are linked to improved response to immunotherapy in ovarian clear cell carcinoma @nature.com
www.nature.com/articles/s41...

What we stand to lose when foreign students are seen as a threat International students enrich university communities and strengthen civic life. We must defend their place in global education.

International students enrich university communities and strengthen civic life. We must defend their place in global education. @nature.com @mchankseliani.bsky.social
www.nature.com/articles/d41...

The Somatic Mosaicism across Human Tissues Network @nature.com @timcoorens.bsky.social
www.nature.com/articles/s41...

Functional amyloid proteins confer defence against predatory bacteria - Nature Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a mechanism th...

Functional amyloid proteins confer defense against predatory bacteria @nature.com @hannahledvina.bsky.social @aaronwhiteley.bsky.social
www.nature.com/articles/s41...

The mutagenic forces shaping the genomes of lung cancer in never smokers @nature.com
www.nature.com/articles/s41...

Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukemia @sabaghassemi.bsky.social
www.nature.com/articles/s41...

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Advancing cancer research via comparative oncology Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...

New paper out! rdcu.be/etKdN Experts in #cancer across the tree of life and philosophers of science teamed up to explore how comparative thinking can improve current approaches to cancer, including conceptually and therapeutically. #evolution #ecology #oncology #philosophy

We are looking forward to an exciting week with great speakers, interesting discussions on Philosophy in Science and intriguing project work! (4/4)

James DiFrisco (Crick Institute, UK) on "Moving beyond conceptual analysis: conceptual methodology for philosophy 'in' science"

Some impressions of the first day of the #PhilInBioMed at University of Bordeaux! (1/?)

Full program here: www.philinbiomed.org/event/bordea...

#BSS2025 #Philosophy #Biology #Medicine #SummerSchool

And obviously, conversations continue during the coffee breaks.

Bertrand Daignan-Fornier on "Biomass experience"

Impressions of Day 2 of the #PhilInBioMed at University of Bordeaux! (1/?)

Full program here: www.philinbiomed.org/event/bordea...

Marie Vasse on "Predictions and Unexpectedness"

#BSS2025 #Philosophy #Biology #Medicine #SummerSchool

My colleague and friend @scripps.edu, @ardemp.bskyverified.social, on the NYT front page today

#Science #Environnement
🐜 "Les invasions biologiques, la menace oubliée"
👨‍🏫 Franck Courchamp, professeur invité sur la chaire annuelle Biodiversité et écosystèmes, introduit son cours de l'année 2024-2025
⏰ Jusqu'au lundi 30 juin 2025
Voir la suite 👉 www.college-de-france.fr/fr/agenda/co...

The first generative AI drug to get to a Phase 2 randomized clinical trial. The small molecule in pill form, rentosertib, showed signs of efficacy for idiopathic pulmonary fibrosis @naturemedicine.bsky.social
www.nature.com/articles/s41...

Thanks to @asm.org for joining this letter and calling for Congressional oversight so that NSF can fulfill its Congressionally-mandated mission and support US science

Great to see @ascbiology.bsky.social join 52 other science societies in a letter to Congress expressing concern over recent organizational and financial developments at NSF, and urging Congress to exercise its oversight authority to preserve American STEM leadership 1/n
aas.org/sites/defaul...

Register for our next ECLC webinar by Marco Montagner, PhD on Understanding the determinants of the invisible phase of metastasis - June 26th, 2025 - USA: 11:00 AM EDT | Europe: 17:00 PM CEST | Australia: 01:00 AM AEST - tinyurl.com/ujer8yw8

Adaptive immunity in barrier tissues Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.

📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025

Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social

#EMBOBarrierTissues

Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer - Nature Medicine An analysis of 18 metagenomic datasets of individuals with colorectal cancer, adenomas and healthy controls yields improved cancer prediction accuracy based solely on gut metagenomics, as well as the ...

🥁NEW publication from our lab:
the largest meta-analysis of gut microbiome associations with CRC!

www.nature.com/articles/s41...

🧵⬇️

1/6

TSSpredator-Web: A web-application for transcription start site prediction and exploration https://www.biorxiv.org/content/10.1101/2025.05.29.656934v1

A collage illustrating diverse biological behaviors across life forms: orange and yellow lichens growing on rock (symbiotic behavior), a close-up of bacteria (microbial interactions), leafcutter ants cooperating to carry a leaf (social insect behavior), a sundew plant trapping an insect (plant predation), and phylogenetic trees representing evolutionary relationships.

What theoretical & methodological challenges emerge when investigating #behavior across the tree of life? We are organizing an interdisciplinary workshop on 'comparative behavioral biology' (Sept. 26-27). Please help us share the open CfA! 📢👇 hiw.kuleuven.be/clps/events/... #philsci #HPbio #evobio

The #PhilInBioMed Summer School has started!
Five days of exciting talks, big ideas, and fun crossovers between philosophy, biology, and medicine.

@philinbiomed.bsky.social

👉 www.philinbiomed.org/event/bordea...

#BSS2025 #Philosophy #Biology #Medicine #SummerSchool

Some of the material shown to participants during the experiment, showing a lineup and information about what the AI thinks about the identification.

Mistaken eyewitness identification is one of the leading causes of false convictions. AI analysis of the statements people make during identifications—e.g., “I am pretty sure,”—can help people assess which witnesses are reliable. In PNAS: www.pnas.org/doi/10.1073/...

Microglial STING is a central safeguard against neurological decline with age Immune pathways and cell types that protect against neurodegenerative processes with aging remain poorly understood. Sulka et al. demonstrate that the innate immune adaptor, STING, provides essential ...

Congrats to my good friend Shruti Sharma!
STING, provides essential protection against blood-brain barrier breaches and neuromotor deficits during physiological aging
@cp-cellreports.bsky.social
cell.com/cell-reports...

Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Cancer-fighting CAR T cells show promising results for hard-to-treat tumours Trial in China is one of the first times the immune therapy has worked against solid tumours.

Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) show promising results for hard-to-treat solid tumors (gastric cancer or gastro-oesophageal junction cancer) @nature.com @thelancet.com
www.nature.com/articles/d41...
www.sciencedirect.com/science/arti...

A tray of Portuguese pastéis de nata.

And we can think of some discussions on the history, philosophy and social studies of biology extending from #ISHPSSB2025 to a coffee table, accompanied by a pastel de nata...
Registrations here ➡️ ishpssb2025.icbas.up.pt/registration...
#hpbio #philsci #histstm #histsci #philbio #hbio #sts