@mariamayan.bsky.social
Aging & Cancer. Connexins | Research Group Leader at @cinbio_uvigo | PI Horizon Europe consortiums | @uvigo | Committed to Women in Science and Equity
📢 ¡No te pierdas la Sesión de Financiación Privada y Filantropía en nuestro #47congresosebbm!
Moderan: María Mayán y @sabiolab.bsky.social
Participan:
🔹 Fundación AECC
🔹 @fundacionfero.bsky.social
🔹 CRIS Cáncer
🔹 Fundación La Caixa
💬 ¡Planes de financiación y apoyo al talento científico!
Small donations to the AACR added up to something big for early-career researcher Madelyn Espinosa-Cotton, PhD. During #SarcomaAwarenessMonth, learn how an #AACRGrants enabled her to study a rare and aggressive type of sarcoma. buff.ly/6WJk6UC
31.07.2025 19:18 — 👍 9 🔁 6 💬 0 📌 0
👉ASEICA reclama➕financiación ante la resolución provisional de la Convocatoria de Proyectos Generación de Conocimiento 2024
@cienciagob.bsky.social ha publicado la resolución provisional de la convocatoria 2024 de Proyectos I+D
Gráfica: @jaestebancbm.bsky.social
ℹ️ www.aseica.es/aseica-recla...
📢 Vigo correrá por VIGO4SAR, liderado desde o CINBIO por @mariamayan.bsky.social e desde o Instituto de Investigación Sanitaria Galicia Sur polo Dr. Juan Carrasco, grazas a Vigo contra el cáncer.
➡️ Para personalizar terapias en sarcomas.
🗓️ A carreira será o 19 de outubro.
cinbio.es/difusion/nov...
On fire! 🔥 Muy agradecidas por este apoyo que refuerza nuestra línea de investigación en #sarcoma
Gracias @vigovscancer por movilizar a toda una ciudad en apoyo a la investigación en cáncer
🗓️Estaremos atentas a las fechas de inscripción! 💪🏻🔬🧬
#Salud #ciencia #cancer
🧿 Vigo contra el Cáncer financiará este 2025 el proyecto de investigación VIGO4SAR
⏺️Dirigido por la doctora Maria Mayan y el doctor Juan Carrasco, se centra en el estudio de los sarcomas
🥼Unha oportunidade para investigadores da saúde humana e animal para conseguir ata 40.000 euros.
Zendal presenta ao seu xurado para decidir o proxecto gañador👇
@natcomms.nature.com
28.07.2025 20:06 — 👍 1 🔁 0 💬 0 📌 0📄 Finally, the open-access Peer Review File is also available! We highly recommend checking it out to see the reviewers' comments and how we addressed each point. Transparency in action 👇
➡️ static-content.springer.com/esm/art%3A10...
👉 www.nature.com/articles/s41...
🧑💻 I would also like to thank our editor at @NatureComms for making the process smooth, highlighting key points to address, and supporting us throughout a full year of revisions, always available, with a truly professional team. A great experience 🙏
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0💰 Thanks for the support to @ageinves.bsky.social @isciiisalud.bsky.social #GAIN @ACIS_sergas and @horizoneu.bsky.social
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0🙏 Special thanks to Eduardo Fonseca and all the clinicians involved, especially Teresa Calleja and Maria Quindos for their essential contributions to this work!
Also grateful to @lab_santamaria @ciccancer and @cafernandezlo @UDC_gal and everyone! Thank you so much! 💙
This project began with Adrian Varela, continued by Amanda Guitian and was completed thanks to the incredible efforts of Paula Carpintero and Alex Carneiro. It wouldn’t have been possible without @bertalsl, Constance Alabert @dundeeuni, and all our amazing collaborators 🙌
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0
🧠 We show for the first time that (1) Cx43–lamin interaction alters DNA repair pathway choice, boosting therapy, preventing resistance, and resensitizing resistant tumours, and (2) we have developed a smart strategy to deliver Cx43 mRNA to tumours🚀
This is our model👇
💊 Restoring Cx43 in tumour cells has been challenging.
After testing multiple strategies, extracellular vesicles (EVs) proved most effective, delivering both Cx43 protein (via their membranes) and Cx43 mRNA, by engineering the EV-producing cells
🎯 Most importantly, restoring Cx43 avoided drug resistance in vitro and prevented resistance in vivo.
Even better, drug-resistant cells, which are more vulnerable to DNA damage, became more sensitive to Cx43 restoration 💪
🧬Thanks to @Gsabiolab @DNA_Repair_USC & @PabloHuertasLab we found that this interaction recruits DNA damage foci to the nuclear membrane, restricting HR & promoting error-prone repair driving genomic instability, which is further enhanced by DNA-damaging drugs like BRAF/MEKi💥
28.07.2025 19:54 — 👍 1 🔁 0 💬 1 📌 0
🔍 What did we find? Surprisingly, Cx43 antitumour effects in BRAF- (and NRAS)-mutant tumours do not seem to rely on its channel activity. Instead, we found Cx43 localizes to the nucleus and strongly interacts with nuclear lamin and DNA repair proteins⚙️
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0⚙️ How? We analysed Cx43 levels and activity in human tumours and mouse models, with upregulated MAPK pathway, including BRAF and NRAS mutations, using different complementary approaches 👩🔬🧑🔬
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0
💭Cx43 shows antitumour activity in many cancers, but the mechanism remained controversial. We hypothesized that restoring Cx43 could help the microenvironment suppress growth and boost therapy response via its channel activity; a “kiss of death”
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0💡 Why? Targeted therapies and immunotherapies have transformed the cancer treatment landscape, yet we continue to face the same challenge since the earliest use of chemotherapy and radiotherapy: drug resistance remains a major barrier to effective cancer treatment🏥
28.07.2025 19:54 — 👍 0 🔁 0 💬 1 📌 0
💥Check out our latest work in @NatureComms We identify a new target to impair DNA repair🧬inducing #senescence and #celldeath through synthetic lethality in combination with cancer therapy🧵
🔗Open access PDF: rdcu.be/euQkW
Importante que medios como @radionacional.bsky.social den visibilidad a avances en investigación en cáncer!
Gracias #EvaSahis por esta entrevista #ConBataBlanca, sobre resultados clínicos tras 15 años de investigación
@cniostopcancer.bsky.social y HighLightTherapeutics
www.rtve.es/play/audios/...
📍La Semana de la Ciencia de ASEICA 2025 comenzará con...
⚫RETREAT #ASEICAMed
📅7OCT
🏟️Bilbao
Punto de encuentro de investigadores clínicos, traslacionales y básicos
▶️Ciencia y Networking
‼️ Posibilidad de Registro único o a todo el #ASEICACongress
https://www.aseica.es/aseicamed-retreat
Frank Beier Bio, Achievement, Legacy, Spouse, Age, Net Worth, Family, Achievements, Education www.peopledirectory.org/frank-beier-...
21.07.2025 16:23 — 👍 2 🔁 1 💬 0 📌 0
El 4 de septiembre en el marco de nuestro #47congresosebbm tendrá lugar la Conferencia Mujer y Ciencia, moderada por María D. Mayán tendremos la ocasión de disfrutar de la ponencia de Diana Guallar del @cimususc.bsky.social - Navigating the epitranscriptome: from pluripotency to ageing
21.07.2025 06:44 — 👍 3 🔁 3 💬 0 📌 0
New ERC report on Europe’s competitiveness! 🇪🇺
"It conveyed a shared message that fundamental research is not a luxury.”
ERC President Maria Leptin on the conclusions from the ERC workshop with leading figures from industry, policy and science.
Read workshop report: erc.europa.eu/news-events/...
📢 Máis de 200 científicas e científicos participaron na VIII edición do CINBIO Annual Meeting.
Este ano o encontro tivo lugar no MARCO, situado no centro da cidade de Vigo.
#8AMCINBIO #teamCINBIO #FondosEuropeos #HR
📣 Persoal investigador do grupo #CellCOM do CINBIO identifica unha vulnerabilidade clave para vencer a resistencia de determinados cancros aos fármacos.
➡️ Liderado por @mariamayan.bsky.social, o estudo publicouse en @natcomms.nature.com.
Máis ℹ en bit.ly/4eGxvT3
#teamCINBIO @uvigo.bsky.social
