Genetic inference of on-target and off-target side-effects of antipsychotic medications
Author summary Many people stop taking antipsychotic medications, not because they don’t work, but because of their side-effects. However, it’s often unclear whether these side-effects are truly cause...
Hello, First post! I have recently got a paper published, we were able to gain insights into the side-effects of anti-psychotic medications using genetic and drug binding data
What's extra interesting is how we are able to infer which receptor the side-effects work through
doi.org/10.1371/jour...
18.08.2025 10:39 — 👍 3 🔁 1 💬 1 📌 0
If you think about it with confidence intervals in mind, it could look like this:
3%: [———————o———]———
5%: ——[—————o-—]-————
7% -———[————o-]-—————
0%: -————[——]-o——————
20.02.2025 10:40 — 👍 12 🔁 0 💬 1 📌 0
Statistical geneticist. Associate Prof at Dana-Farber / Harvard Medical School.
www.gusevlab.org
Interested in psychiatry/psychotropics, psychopharmacology, neuro.
I may seem inactive, but perhaps I'm a prodrug...?
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CPsychol CSci AFBPsS
The Bristol Biomedical Research Centre is led by University Hospitals Bristol and Weston NHS Foundation Trust in partnership with the University of Bristol. We're funded by @nihr.bsky.social (National Institute for Health and Care Research)
Research Fellow at the University of Bristol. My research interests are in mental health, autism and health behaviours, primarily using epidemiological approaches.
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