Thea Jacobs

Photo gallery: “Lange Nacht der Universitätsmedizin” – Impressions from the Multiscale Imaging Centre On September 12, 2025, the University and University Hospital Münster opened their doors to the public during the “Lange Nacht der Universitätsmedizin”. At the Multiscale Imaging Centre, many visitors...

Approximately 14,000 visitors attended the “Lange Nacht der Universitätsmedizin Münster”, which marked the highlight of the anniversary year celebrating 100 years of the Faculty of Medicine and the University Hospital. www.uni-muenster.de/Cells-in-Mot...
@sfb1348.bsky.social @uni-muenster.de

Besuchen Sie uns zur „Langen Nacht der Unimedizin Münster“ am 12. September 2025! Zahlreiche Forschungsgruppen aus der Zell-Dynamik- und Imaging-Community der @uni-muenster.de und @sfb1348.bsky.social öffnen ihre Labore für die Öffentlichkeit!
lange-nacht-muenster.de

Super cool work from our institute!

Supracellular control and coordination of tissue morphogenesis, through supracellular actomyosin assemblies, that is what my lab @cellbiol-mrclmb.bsky.social @pdncambridge.bsky.social and I like to dig into at the moment! Fascinating and beautiful! journals.biologists.com/dev/article/...

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social

How does the yolk get into the egg? Studies on the fruit fly | Thea Jacobs Cells build connections in organisms, and thus, form tissues that only allow certain substances or cells to pass through. In her doctoral thesis, biologist Thea Jacobs has carried out investigations o...

Using a simple model – #FruitFly eggs – biologist @theajacobs.bsky.social is investigating how cells build connections, and thus form tissues that only allow certain substances or cells to pass through. Here, she provides insight into her day-to-day research. @sfb1348.bsky.social

uni.ms/d3ry0

Inflammation in the brain: My research on the fruit fly | Bente Winkler Neurobiologist Dr Bente Winkler is investigating how fruit fly brains react to inflammation. To do this, she is using genetically modified fruit flies in which a reaction of the immune system can be a...

Neurobiologist Bente Winkler @b-wink.bsky.social investigates how the brain reacts to #neuroinflammation. For this, she is using genetically modified #Drosophila flies that enable an artificial activation of the immune system. Read more: uni.ms/48q7k

Exciting @sfb1348.bsky.social with Katja Rust (Philipps-University Marburg) on Thursday. She will speak about "A single-cell analysis of Hh and EGFR-RAS: Independent signaling pathways prevent tumorigenesis". More information: www.uni-muenster.de/SFB1348/en/i...
Everyone is welcome!

Confocal image of Ajuba in Drosophila follicle cells. The Protein localizes at Tricellular Junctions.

It’s #FluorescenceFriday again!
@maikbischoff.bsky.social encouraged me to post more beautiful images, so I hope you enjoy this image of Ajuba at Tricellular Junctions in #Drosophila 🪰 want to know more? Click here: doi.org/10.1016/j.cu...

Self-supervised, label-free 3D cell imaging is here EPFL researchers introduce CellSeg3D, a self-supervised tool for 3D cell segmentation in fluorescence microscopy, eliminating the need for manual labeling and enhancing accessibility for various biolo...

🥰 Self-supervised, label-free 3D cell imaging is here

Congrats to Cyril on this very cool first, first author publication 🏆! This started when he was a bachelor's student (and he's now completing his masters!).

And many thanks to my other awesome co-authors🙏

elifesciences.org/articles/99848

Just one week to go ⏳ until the "Cellular Interfaces Across Scales: From Molecules to Tissue Dynamics" meeting @sfb1348.bsky.social @uni-muenster.de
We can't wait to see you there!
crc1348-conference.ycode.site
#DynamicCellularInterfaces #Münster

Epithelial biology: Holding the corners together A new study reveals that the Drosophila follicular epithelium opens its permeability barrier to allow passage of yolk to the oocyte by relaxing, not actively pulling open, cell vertices. This work res...

Great Dispatch article by @tarafinegan.bsky.social on our new paper by @theajacobs.bsky.social in @currentbiology.bsky.social - thanks for condensing our findings so clearly and nicely!
Epithelial biology: Holding the corners together: shorturl.at/cMziC
@sfb1348.bsky.social @uni-muenster.de

This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.

I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.

Paris Now #StandUpForScience

@standupforscience.bsky.social
@standupforscifr.bsky.social
compliments of sulekh.bsky.social one of our postdocs!

Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.

Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h

#science - in the light of potential enshittification of #PubMed - Ihere's an European alternative to PubMed - www.europepmc.org

It's not censored or brought down by would-be-dictators.🧪

Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila Cell vertices integrate forces in epithelia and play key roles in regulating barrier function. Jacobs et al. show that modulation of actomyosin contractility at cell vertices controls tricellular junc...

Our new paper by @theajacobs.bsky.social in @currentbiology.bsky.social shows how relaxation of tension, rather than active actomyosin-based force, allows opening of cell #vertices to increase #epithelial permeability shorturl.at/Wnb2n
@sfb1348.bsky.social @uni-muenster.de

It's always mesmerizing seeing how these group of cells move.

ℹ️Border cells invading through nurse cells
ℹ️Drosophila S9 egg chambers

Drosophila ovariole stained for E-Cad (cyan) and F-Actin (magenta).

#fluorescentfriday with a Drosophila ovariole stained for E-Cad (cyan) and F-Actin (magenta). We use the follicle epithelium as a model to study junction remodelling and barrier formation. Check out our preprint on how Rok regulates paracellular permeability: www.biorxiv.org/content/10.1...

5/ 🐣 With this technology at hand, we build the Virtual Embryo Zoo (virtual-embryo-zoo.sf.czbiohub.org), a showcase of cell-tracking datasets from 6 model organisms, including zebrafish and Drosophila. Explore them interactively, trace lineages, and download tracking data for further analysis! 🐠🐭