Mirouse lab

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

PREACH!

www.nature.com/articles/s41...

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

Black and white portrait of John Gurdon, 1971

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

40 years since the Heidelberg genetic screen that revolutionized developmental and cell biology ABSTRACT. Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, wh...

You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....

Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Cities reachable by train from Vienna in under 10 hours

Civilization, visualized

Positively mesmerizing: www.chronotrains.com/en/explore/2...

@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.

Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included.

training.institut-curie.org/courses/deve...

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

📣 Junior PI Opportunity
Join CNRS Strasbourg to lead cutting-edge research on host-pathogen interactions in insects 🪰
450k€ package | Drosophila, RNA, immunity
IBMC + Labex NetRNA network
📅 Apply by June 30, 2025
🔗 ibmc.cnrs.fr/en/laboratoi...
#RNA #Insects #Drosophila #NetRNA #Immunity #JobAlert

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

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congrats! It's an awesome story.

$500 million is… less than 1.25% of the NIH’s 2024 budget.

When I say there is no capacity to absorb the shock, I mean it.

11 Thesis topics proposed by iGReD for the SVSAE doctoral school's 2025 competition - iGReD Team: Environment, Metabolism, spermatogenesis, pathophysiology and inheritance Analysis of spermatogonial stem cell homeostasis and their chemoresistance.   Team: ERO: Epigenetic Regulations & Ontoge...

www.igred.fr/en/12-thesis...

ERC to double allowance for researchers moving to EU The European Research Council (ERC) is doubling the relocation allowance it makes to researchers coming to the EU to take up one of its grants. At present it offers third-country researchers up to €1 ...

the ERC has added a million euro for researchers moving to Europe.

For using #RUSH to control and visualize membrane trafficking in Drosophila, see also shorturl.at/96Qo3
Witness the journey of cargo from the ER to the plasma membrane and out of the cell in 5 minutes:

A) Diagram of the RUSH system. The Halo-tagged cargo is retained in the ER by the binding of the Streptavidin binding peptide (SBP) to Streptavidin (StrepA), which is fused to the ER retention signal, KDEL. The cargo is synchronously released upon the addition of biotin, which outcompetes SBP for binding to Streptavidin.B) Diagram of the tagged cargo constructs used in this study. C) Steady state expression of UAS-SBP-Halo-Cadherin99c (magenta) under the control of traffic jam-Gal4, showing its localization to the apical microvilli. Phalloidin staining of F-actin (green) labels the apical microvilli in the follicle cells and the oocyte. Scale bar 10 µm. D) Steady state expression of UAS-SBP-SNAP-Ndg (magenta) under the control of traffic jam-Gal4, showing its localization to the basement membrane. Actin is shown in green. Scale bar 10 µm. E) En face view of SBP-SNAP-Ndg in the basement membrane. Scale bar 10 µm. F) Time course of SBP-Halo-Cadherin99C trafficking in fixed samples. G) 25 min after release from the ER, Cad99c (green) localizes to subapical puncta that are labeled by Rab11 (magenta). Scale bar 10 µm. In all figures with a cross-section of the follicle cells, apical is toward the top of the image and basal toward the bottom.

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp

Ideally, we'd like authors to cite a recent FlyBase publication. There's a blue box with the text "Citing FlyBase' on our homepage that takes you a page detailing how to cite us wiki.flybase.org/wiki/FlyBase...

And cite the model organism databases and other resources you use!

Genetically encoded reporters of actin filament organization in living cells and tissues Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...

Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

Wow!
Pilot Phase Pricing:
Fly and worm model organism 30x whole genome sequencing and analysis
$25 per sample for gDNA submissions
$50 per sample for whole organism
Pricing is valid through June 30,
results expected within approximately six weeks or less.

It takes 2 to PCP (or 3 to align with global cues)! Congrats @eposfai.bsky.social and Danelle!

⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.

Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump » Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son or...

French researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated.

Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...