Abdou Rachid Thiam

Congratulations 🎉🎉🎉🎉 @olzmannlab.bsky.social @arrudalab.bsky.social

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

Kudos to Tobias ! Warm greetings to my MSF freinds, sad I am missing it this year.

#VAMP7-dependent late endosomal #secretion of #ER and #mitochondrial proteins impacts the #tumor #microenvironment and #macrophage engagement
www.nature.com/articles/s41...

📢 Registration for the 28th Annual Meeting of the Club Exocytose-Endocytose is open until April 15 !
👉 Register here: exoendo.org/en/evenement...
Please share widely!
@gdrimabio.bsky.social @biologists.bsky.social @sbcf.bsky.social @embo.org @febsletters.bsky.social @sneuroendo.bsky.social

A model to describe what we show in the paper. INVs are important for sequestering GLUT4 and related proteins into GSVs, the vesicles that are mobilised in response to insulin.

🚨 We have a new preprint out! 🧪

In this paper we look at GLUT4 trafficking. This is a short explainer thread, but please read the paper!

1/n 🧵

www.biorxiv.org/content/10.6...

À M À Z I N G

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM

Huge congrats to @manuelthery.bsky.social and all the Cytomorpho lab. The "Living Architectures" performance at @museeorsay.bsky.social was breathtakingly beautiful

Thanks!!

I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.

www.biorxiv.org/content/10.6...

Triglyceride/Cholesterol Ester Ratio Encodes Lipid Droplet Size and Diversity https://www.biorxiv.org/content/10.64898/2026.01.21.700800v1

The work by @danialv.bsky.social is now out in @pnas.org with a few changes after peer-review. Have a look if you are interested in lipid transport by bridge lipid transfer proteins (BLTPs)...
www.pnas.org/doi/10.1073/...

Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

Such a pleasure to write this review on #LipidDroplet heterogeneity, dynamics and #organelle interactions with Mike @hennelab.bsky.social ! Thank you to the editorial team @natrevmcb.nature.com and to Yoni Malis for assistance with draft illustrations

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇

Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!

Interested in lipids? Join us @ the 2026 FASEB Lipid Droplet: From Mechanisms to Disease Conference (July 26-30, Scottsdale, AZ). Registration is now open!

events.faseb.org/event/Lipid-...

We are co-locating with the FASEB Phospholipids SRC! Register for one to enjoy BOTH meetings!

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

MOSPD3 mediates the ER recruitment of ATG2A to promote autophagy ATG2A transfers glycerophospholipids from the endoplasmic reticulum (ER) to support expansion of the isolation membrane at ER membrane contact sites. While a role for ATG18/WIPI4 in targeting ATG2A to...

MOSPD3 mediates the ER recruitment of ATG2A to promote autophagy www.biorxiv.org/content/10.6...

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime:

rupress.org/jcb/article/...

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Crucial and amazing findings! Bravo.

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Seipin Regulates Caveolin-1 Trafficking and Organelle Crosstalk Caveolin-1 (CAV1), the main structural component of caveolae, is essential in various biological processes, including mechanotransduction, lipid metabolism, and endocytosis[1][1]–[4][2]. Deregulation ...

Bravo 👏👏👏, very nice work!
Happy to see many consistencies with our recent study. In our BioRxiv paper, we presented late endosome-LD connections leading Cav1 to LDs :-).
www.biorxiv.org/content/10.1...