Rob Parton

Examples of in vitro measurements (left panel) and the in vivo mechanical landscapes where tissues and cells experience complex compound forces (right panel). In vitro experimental techniques can provide detailed information about specific properties of mechanosensitive ion channels. However, an experimental gap remains in understanding how channels are activated and the consequences of their function in complex in vivo settings.

In their Opinion article, Samantha Webster @llssam.bsky.social, Remi Brynn and Kate Poole @katepoole.bsky.social consider how perspectives from both cell biologists and biophysicists will be crucial for characterising mechanosensitive ion channels in vivo.
journals.biologists.com/jcs/article/...

🎵 Every move you make, every telomere you shake, every strand you break, we’ll be watchin’ you...🎵 Advanced-imaging guru needed to keep a close eye on plant synthetic chromosomes in our ARIA research project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply now: bit.ly/3GKSRSA

“Revolutionary Science Comes from Unexpected Angles”

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

Image showing three covers of Journal of Cell Science

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social)
that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more.
For details, visit: journals.biologists.com/jcs/pages/re...

Figure showing that photoreceptor loss in atp11anl1007 mutants is partially light dependent.

Alexia Hawkey-Noble, Cameron Tobin, Curtis French and colleagues find that the P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in #zebrafish.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess

Do you qualify for APC-free Open Access publishing? Find out at biologists.com/read-publish/institutions

Are you eligible for fee-free #OpenAccess publishing? Does your institution have a Read & Publish agreement with us? Check if your institution is one of over 1,000 participating.

www.biologists.com/library-hub/...

#ReadAndPublish #Publishing #Academia #Research

Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:

“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”

I cannot wait for this meeting, it's going to be awesome

JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano

In their Cell Science at a Glance article, Antigoni Diokmetzidou and Luca Scorrano summarise the mitochondrial contacts characterised in mammals, the molecular mechanisms underlying their formation, and their principal functions.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess

Great to see this issue out! Huge thanks to our Guest Editors, Ana Garcia-Saez and Heidi McBride (@mitodynamics.bsky.social), for coordinating it!
#mitochondria

Microscopy Training Grants Supporting microscopy training for early-career researchers in cell biology Apply for a grant of up to £1,000 Application dates: 6 June 2025 5 September 2025 7 November 2025

If you would like to attend a #microscopy or #bioimageanalysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @jcellsci.bsky.social and @focalplane.bsky.social.

Next deadline: 6 June 2025

www.biologists.com/grants/jcs-f...

#Training

Potential bidirectional communication between the liver and the central circadian clock in MASLD npj Metabolic Health and Disease - Potential bidirectional communication between the liver and the central circadian clock in MASLD

Delighted to share this new review article discussing the potential bidirectional communication between the liver and the central circadian clock.

The systemic relationship is likely more complex than we thought!

rdcu.be/egZWQ

JCS cover showing a fungi trap structure. Ring-like structures at the cellular level are rare in biology. The traps of nematode-trapping fungi are good examples. They are ∼500 µm in diameter and consist of three to four cells. In the case of Arthrobotrys flagrans, the traps are adhesive and attract nematodes like C. elegans. The image shows a forming ring, the tip of which will soon fuse with the hypha underneath. So-called cell-end marker proteins (in green) help to reorient the growth zone for bending. The blue stain shows the chitin-containing cell walls of the tubular cells.

Issue 8 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image is an A. flagrans trap with cell-end marker proteins in green & cell walls in blue. These traps are adhesive and attract nematodes. See article by Kriegler et al.
journals.biologists.com/jcs/article/...

Had fun writing this review with Pete Cullen @peterjcullen1.bsky.social

Stehbens, S. J., Scarpa, E., & White, M. D. (2024). Perspectives in collective cell migration - moving forward. Journal of cell science, 137(12), jcs261549. #EpithelialMechanicsReview
buff.ly/qBZgwkr

JCS poster on regulation of cell migration by extracellular matrix mechanics at a glance Cole Allan, Ovijit Chaudhuri

Also in Issue 7:
- Research Highlights on ATG9A INVs, airway epithelia & Formin 3
- JCS–David Stephens Prize
- Emmanuel Derivery @deriverylab.bsky.social Interview
- Regulation of cell migration by ECM mechanics
- Data exploration in quantitative #cellbio
journals.biologists.com/jcs/issue/13...

We support the scientific community - basically we're the good publisher who gives back which is why you should submit papers to our journals rather than supporting share holders!

Image of three covers of Journal of Cell Science

Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...

Daylight saving time ends Sunday. Why do we change our clocks? And how does it affect our bodies? Here’s how your body might respond when you turn your clock back an hour on Saturday night.

Time change season is here! While most Australian states fall back from DST, QLD, WA & NT don't practice it. @benweger.bsky.social and I break down why this might be a win in our latest piece for The Conversation. ⏰☀️ @emcra-imb.bsky.social

theconversation.com/daylight-sav...

ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability Tambrin et al. show that the Cdc42/Rac GAP ARHGAP12 promotes the flux of macromolecules across tight junctions by suppressing junctional actin assembly and tension via N-WASP and the Arp2/3 complex. T...

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

We are looking for a PhD candidate starting on the 01-10-2025. The project aims to understand how the host cells use copper and oxidative species to fight Salmonella infection and how this pathogen evades this antimicrobial response.

SHORT DEADLINE ! 20-04-2025
jobs.inrae.fr/en/ot-25517

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Lotte B. Pedersen Areas of expertise: Cell biology, primary cilia, centrosomes, intraciliary trafficking (IFT), cilia assembly, signalling via cilia.

Our Guest Editor @lottepedersen.bsky.social is attending our Biologists @ 100 conference. Reach out to Lotte if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci...
Submission deadline: 31 March
#biologists100

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Pleasantine Mill (Guest Editor, Special Issue: Cilia and Flagella - from Basic Biology to Disease Areas of expertise: Cilia, ciliopathies, disease genetics, genetic screens, genome editing, primary ciliary dyskinesia, ciliogenesis.

Our Guest Editor Pleasantine Mill @cilialab.bsky.social is attending #biologists100. Reach out to Pleasantine if you have questions about submitting your research to our special issue on cilia and flagella biology: journals.biologists.com/jcs/pages/ci...
Submission deadline: 31 March

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Guillaume Jacquemet Area of expertise: Light microscopy, cell adhesion, cell biology, imaging.

Our Associate Editor @guijacquemet.bsky.social is attending our Biologists @ 100 conference. Reach out to Guillaume at the conference if you have questions about submitting your research to JCS or visit our website to find out more: journals.biologists.com/jcs/pages/re...
#biologists100

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Charlotte Kirchhelle Areas of expertise: Plant cell biology, endo-membrane transport, quantitative imaging, plant morphogenesis.

Our Associate Editor @ckirchhelle.bsky.social is attending the Biologists @ 100 conference. Reach out to Charlotte at the conference if you have questions about submitting your research to JCS or visit our website to find out more: journals.biologists.com/jcs/pages/re...
#biologists100

We’ve launched Etch A Cell – ImmunoExplorers, a citizen science project focused on identifying immune cells to advance understanding of kidney transplant rejection Learn more: www.zooniverse.org/projects/h-s... #CitizenScience #KidneyHealth

Cartoon showing key mechanotransduction signalling pathways to the nucleus. Mechanosensitive ion channels at the plasma and nuclear membranes allow Ca2+ entry into the cytoplasm and nucleus, activating downstream signalling pathways. NE stretching opens NPCs, facilitating entry of transcription factors (TF) and transcriptional coregulators (TCR) that alter gene expression. Additionally, NE stretching activates Ca2+ channels in the ER, promoting Ca2+ entry into the nucleus. Stretch-induced activation of cytosolic phospholipase A2 (cPLA2) further drives the arachidonic acid (AA) pathway, leading to gene expression changes.

In their Review, Julien Morival, Anna Hazelwood and Jan Lammerding @lammerdinglab.bsky.social discuss new insights and technological advances in understanding nuclear mechanotransduction.
journals.biologists.com/jcs/article/...

Special Issue Cilia and Flagella: from Basic Biology to Disease Guest Editors: Plesantine Mill and Lotte Pedersen Submission deadline: 1 March 2025 Journal of Cell Science logo Call for papers

Only a few days left to submit your latest research to @jcellsci.bsky.social‬ 's upcoming Special Issue on #cilia and #flagella, coordinated by Pleasantine Mill @cilialab.bsky.social & Lotte Pedersen @lottepedersen.bsky.social .
📆 Deadline: 1 March
https://bit.ly/4ed1Re7

#CallforPapers #CellBio

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Michael Way to the left, text to the right 100 extraordinary biologists Michael Way Michael Way is the current Journal of Cell Science Editor-in-Chief after serving as an Editor since 2005. He is a Principal Group Leader at The Crick, UK researching the role of Arp2/3 iso-complexes, actin and microtubules in Vaccinia virus infection and other processes. #100biologists #biologists100

We are featuring Michael Way, current Editor-in-Chief of @jcellsci.bsky.social and Principal Group Leader at @crick.ac.uk, as our next extraordinary biologist this week. To know more about JCS and Michael's role, read this Editorial: bit.ly/3CUARU1.
#100biologists
@drmichaelway.bsky.social

In @elife.bsky.social: Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish doi.org/10.7554/eLif...