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Paul Fiedler

@pfiedler.bsky.social

🧠 medical neurosciences @Charité interested in memory, sleep, cognition, neuron-glia, health, and scicomm 🌈

452 Followers  |  3,335 Following  |  6 Posts  |  Joined: 17.04.2025
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Posts by Paul Fiedler (@pfiedler.bsky.social)

These reviews on neural manifolds are super relevant to today’s world of large-scale population recordings. How do we link circuits, population geometry, dynamics, and function?

β€œA neural manifold view of the brain” from Perich, Narain, and Gallego 2025

www.nature.com/articles/s41...

(1/2)

01.03.2026 17:19 β€” πŸ‘ 33    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0
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Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

Many living people carry fragments of Neanderthal DNA, remnants of ancient interbreeding events, with uneven distribution across chromosomes. New work by @sarahtishkoff.bsky.social lab suggests patterns are most consistent with Neanderthal contribution to human populations being highly male biased.πŸ§ͺ

26.02.2026 19:27 β€” πŸ‘ 58    πŸ” 25    πŸ’¬ 5    πŸ“Œ 0
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1/9 New paper with @gonzalezgarcia.bsky.social and @lindedomingo.bsky.social : β€œCharacterising semantic prioritisation in visual working memory.”
Core question: when we hold visual info briefly in mind, what gets accessed first: perceptual details or semantic meaning?

26.02.2026 07:39 β€” πŸ‘ 30    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
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198 effect sizes in ego depletion resesrch showed an effect size of d=0.62. Preregistered large replications (including some by original authors) yielded an effect size of 0. No one has been able to offer any other explanation for this huge research waste than massive p-hacking.

23.02.2026 20:03 β€” πŸ‘ 127    πŸ” 45    πŸ’¬ 5    πŸ“Œ 7

#neurojobs

21.02.2026 12:29 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

#neurojobs

21.02.2026 12:28 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

#neurojobs

21.02.2026 12:28 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

#neurojobs

21.02.2026 12:28 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Postdoctoral Research Fellow in Social Decision Neuroscience at University of Birmingham Explore an exciting academic career as a Postdoctoral Research Fellow in Social Decision Neuroscience. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

We are recruiting! Postdoctoral research fellow at www.sdn-lab.org, studying the computational & neural basis of social decision-making. Birmingham is a fantastic & affordable place to live, with one of the youngest populations in Europe & over 600 parks. Please share!
www.jobs.ac.uk/job/DQO275/p...

20.02.2026 10:54 β€” πŸ‘ 36    πŸ” 46    πŸ’¬ 1    πŸ“Œ 1
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The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

20.02.2026 20:29 β€” πŸ‘ 258    πŸ” 77    πŸ’¬ 12    πŸ“Œ 11
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Our paper is out in @natneuro.nature.com!

www.nature.com/articles/s41...

We develop a geometric theory of how neural populations support generalization across many tasks.

@zuckermanbrain.bsky.social
@flatironinstitute.org
@kempnerinstitute.bsky.social

1/14

10.02.2026 15:56 β€” πŸ‘ 273    πŸ” 100    πŸ’¬ 7    πŸ“Œ 1
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Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differences Gurholt et al. report associations between obesity and regional white matter phenotypes across commonly used diffusion magnetic resonance imaging metrics,

Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differences academic.oup.com/braincomms/a...

04.02.2026 05:44 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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"Nested spatiotemporal theta–gamma waves organize hierarchical processing across the mouse visual cortex" www.nature.com/articles/s41...

traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it πŸ™‚

#VisualizationInspo

04.02.2026 10:31 β€” πŸ‘ 24    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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🚨 Preprint altert 🚨

**Opposite Effects of Alpha Oscillations on Mind-wandering With Eyes Open and Closed**

www.biorxiv.org/content/10.6...

Led by Esther Thielking and Luca Iemi!

26.01.2026 06:54 β€” πŸ‘ 36    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0

it's easy to create custom feeds for bluesky based on regular expressions, here's an attempt for rhythms in the brain:

bsky.app/profile/did:...

feeds with a curated user list amplify often the same high-profile posters, I feel this maybe has a better chance of catching more obscure content.

29.01.2026 09:28 β€” πŸ‘ 24    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0
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Now out in iScience: Alpha power indexes working memory load for durations

How does the brain store 'durations' in working memory?

πŸ‘‡πŸ‘‡πŸ‘‡

www.cell.com/iscience/ful...

Collaborative effort between @brainthemind.bsky.social and MNE-Python/INRIA.

29.01.2026 08:11 β€” πŸ‘ 34    πŸ” 12    πŸ’¬ 2    πŸ“Œ 1
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**How distributed is the brain-wide network that is recruited
for cognition?**
That goes to the top of the list!
#neuroskyence
doi.org/10.1038/s415...

05.12.2025 18:50 β€” πŸ‘ 172    πŸ” 43    πŸ’¬ 6    πŸ“Œ 2
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Cognitive Neuroscience Research Laboratory Manager at University of Oxford Check out jobs.ac.uk for opportunities in professional services, including Cognitive Neuroscience Research Laboratory Manager. Apply today and learn more about the role.

Last week to apply! Cognitive Neuroscience Research Laboratory Manager at @oxexppsy.bsky.social (with links to @oxcin.bsky.social and @ox.ac.uk)

www.jobs.ac.uk/job/DPZ833/c...

19.01.2026 15:46 β€” πŸ‘ 15    πŸ” 21    πŸ’¬ 1    πŸ“Œ 2
'

RA jobs in Oxford working on a Wellcome Trust funded grant. Neuroimaging, neurostimulation, computational modelling-- what's not to like!

my.corehr.com/pls/uoxrecru...

19.01.2026 12:57 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

#NeuroJobs

19.01.2026 17:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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It won't actually exist for another month or so, but because it now 'exists' on amazon, I'll humbly observe that, after working through this book, your student/trainee would be able to read and understand all but two or three papers in this week's J. Neurosci. Check it out:

16.01.2026 22:38 β€” πŸ‘ 132    πŸ” 38    πŸ’¬ 5    πŸ“Œ 0
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Time Cells in the Human Brain Support Working Memory Maintenance Working memory (WM), the active retention of information over short periods, is a fundamental cognitive function, yet its underlying neural mechanisms remain unclear. In rodents, cue-selective "time c...

Time Cells in the Human Brain Support Working Memory Maintenance
www.biorxiv.org/content/10.6...

14.01.2026 20:54 β€” πŸ‘ 28    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
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A unifying account of replay as context-driven memory reactivation A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing a new account of how and why replay occurs.

β€œA unifying account of replay as context-driven memory reactivation” doi.org/10.7554/eLif...

Been waiting for this one for a while! Congrats @annaschapiro.bsky.social @neurozz.bsky.social

14.01.2026 23:27 β€” πŸ‘ 37    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Neural representations of visual memory in inferotemporal cortex reveal a generalizable framework for translating between spikes and field potentials Translating neurophysiological findings requires understanding the relationship between common measures of brain activity in animals (spiking activity) and humans (local field potentials, LFP). Prior ...

🚨 New preprint!

Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question.

www.biorxiv.org/content/10.6...

🧡 (1/10)

🧠🟦 πŸ§ πŸ’»

05.01.2026 15:21 β€” πŸ‘ 109    πŸ” 33    πŸ’¬ 3    πŸ“Œ 6
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Preprint on PANDORA by Aslan Abivardi:

A massive archive of UK Biobank brain imaging from 82K subjects. For each of 98 sub-modalities (e.g., FA from dMRI), the images are collated into a convenient subjectsXvoxels HDF5 file.

pages.fmrib.ox.ac.uk/pandora/web/

www.medrxiv.org/content/10.6...

07.01.2026 08:14 β€” πŸ‘ 42    πŸ” 18    πŸ’¬ 2    πŸ“Œ 2
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🚨 What if evolution is the ”law”… and networks are the machines that do the work?

In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! πŸ§ͺ🌐🌍🧬🦠

πŸ‘‰ iopscience.iop.org/article/10.1...

🧡 1/

16.12.2025 09:04 β€” πŸ‘ 134    πŸ” 44    πŸ’¬ 8    πŸ“Œ 3

Artificial hibernation uncovers distinct synaptic engram architecture for memory retention https://www.biorxiv.org/content/10.64898/2025.12.09.692927v1

11.12.2025 20:15 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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Priority coding in the visual system - Nature Reviews Neuroscience Prioritization of visual inputs manifests itself in different behavioural signatures. In this Review, Rust and Cohen describe these signatures and their neural correlates and suggest that the brain us...

That is to say: not all types of dimensionality reduction are misguided. Some are wrong; some are useful. Among the useful:

www.nature.com/articles/s41...

11.12.2025 23:24 β€” πŸ‘ 9    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset sizeβ€”we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...

11.12.2025 15:32 β€” πŸ‘ 224    πŸ” 64    πŸ’¬ 7    πŸ“Œ 10
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Our new paper "Inconsistent outcome measurement in depression psychotherapy trials: A systematic historical and meta-analytic review over the past 50β€―years" led by @antoniasprenger.bsky.social is out now in JAD.

πŸ§ͺ #PsychSciSky

www.sciencedirect.com/science/arti...

11.12.2025 00:06 β€” πŸ‘ 66    πŸ” 24    πŸ’¬ 3    πŸ“Œ 0