Rachel Gottschalk

ICYMI: Parsing the STING in pulmonary hypertension—

Andrew J. Bryant & team report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation: buff.ly/DWmLPLp

NIH is already feeling the effects of LLMs.

A new policy was posted yesterday that limits the number of proposals that can be submitted by any one investigator.

grants.nih.gov/grants/guide...

Junior, Assistant, or Associate Specialist – Xue Lab University of California, Irvine is hiring. Apply now!

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601

Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids Gastruloids are three-dimensional stem-cell-based models that recapitulate key aspects of mammalian gastrulation, including formation of an anterior-posterior (AP) axis. However, we do not have detail...

This is such a cool paper and dataset from lab of @arjunraj.bsky.social. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things...

www.biorxiv.org/content/10.1...

Regulation of inflammatory responses by pH-dependent transcriptional condensates Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…

Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...

Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

'In the present study, we found evidence that the brain and immune system may be central regulators of aging and longevity in humans, as aged brains are most strongly predictive of earlier mortality, and youthful brains and immune systems are uniquely predictive of longevity.'

My NIH diversity supplement was reinstated! 🥳

This is not the time to keep quiet or feel defeated by this administration. This is the time to raise hell 🔥 and be heard ✊🏽

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Thrilled to re-share our tweetorial on Bluesky: now out in @cp-cell.bsky.social (🔗 tinyurl.com/3a55tsky) - we present a framework to accelerate variant classification, diagnosis & treatment of inborn errors of immunity. A dream MD/PhD project, which has already led to the treatment of a patient.

@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article) Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

New powerful article up in the New York Times on cancelled and delayed grants

www.nytimes.com/interactive/...

Super cool new paper from the O'Shea lab. STAT interactions and consequences for inflammatory responses during viral infection.

www.science.org/doi/10.1126/...

@jclinical-invest.bsky.social preview:
IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
www.jci.org/articles/vie...
article
www.jci.org/articles/vie...

Cytokines 2025 promises to be an exceptional program! Visit seattle.cytokinesociety.org for the full list of invited speakers, to submit your abstract for an oral or poster presentation by June 18, or register today. You don't want to miss this year.

Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease Lyme disease (LD) is growing in incidence, with nearly 500,000 cases diagnosed annually in the United States. Despite treatment, some patients experience persistent symptoms. The immune mechanisms und...

Check out this multiomics study by @naehasubramanian.bsky.social on Lyme disease patients. It reveals localized immune responses at the site of infection, rather than in the periphery.

www.biorxiv.org/content/10.1...

Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Pittsburgh after-school programs left scrambling as federal funding cuts hit the region Pittsburgh-area programs reel with recent federal grant terminations from the National Science Foundation.

Heartbreaking effects of NSF, Americorps cuts to Pittsburgh’s after school programs that support and enrich our city’s kids.

The need and benefits of these programs is obvious. Isn’t this what we pay taxes for? Doubt philanthropy can take over.

www.publicsource.org/federal-fund...

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

"Modeling the #HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death"

We're pretty excited about this one.

doi.org/10.1182/bloo...

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international)

We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.

Download this massive database here for free: research.jhu.edu/rdt/funding-...

Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.

#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...

IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms - Nature Immunology Ivashkiv and colleagues show that IL-10 inhibits the expression and DNA binding of IRF1 and IRF5, two transcription factors that have an amplifying role in the induction of inflammatory NF-κB target g...

#EpigeneticPower! Ivashkiv, Mishra &co show @natimmunol.bsky.social that anti-inflammatory IL-10 epigenetically silence IRF1 & IRF5 gene transcription by decreasing H3K27ac & chromatin accessibility, thus preventing sustained #interferons & IL6/TNF signaling! www.nature.com/articles/s41...

PhD/Postdoc in Spatial Omics for Cardiology Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

We have an opening for a PhD/Postdoc in Spatial Omics for Cardiology in Heidelberg 🫀 #job #academicjob #phd #postdoc #cadiology 👇
jobrxiv.org/job/heidelbe...

The five senses of immunity A genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behavioral, shared and population level immunity redefining our understanding of the ways organisms communicate among and defend themselves.

The five senses of immunity #immunology