Douglas Kell

My chum reminds me: "The England India cricket series was a day longer than Liz Truss's premiership in duration (46 days from start to finish). Far more enjoyable, exciting, happy and socially more cohesive." Too right.

1/
Many of us who developed #LongCOVID in the first wave in 2020, noticed an abrupt change in our nails -

@resiapretorius.bsky.social
Via @dbkell.bsky.social

www.preprints.org/manuscript/2...

(A to F) Whole blood scanning electron microscopy of micrograph data previously collected in published studies. (A) A few plasma deposits are discernible within the blood sample of a healthy participant 173 ; (B) systemic lupus erythematosus174; (C and D) acute COVID-19 during the initial wave in 202030; (E) rheumatoid Arthritis; (F) Alzheimer's-type disease. 176

COVID-associated endothelial dysfunction and endothelialitis. Schematic representation of COVID-associated ED and endothelialitis. (1) Under pathological conditions, Type I and Type II endothelial activation—together with endothelial cell injury, such as endothelial cell apoptosis and necrosis—are all involved in ED. 39 (2) Endothelial activation promotes the production of various cytokines, chemokines, and other biomolecules that are involved in coagulation and the immune response. 40 (3) Viral persistence may contribute to ongoing endothelial inflammation or ED in Long COVID. 87 88 (4) After invasion of the endothelial cells by the virus, P-selectin, TF, ICAM1, VCAM1, and PAI-1 are expressed on these cells and ultra-large VWF multimers are also released. 58 (5) The downregulation of ACE2 favors ED 39 135 136 137 and leads to (6) a dysregulated local RAS with increased levels of Angiotensin II. 55 (7) Capillary rarefication (indicating an inflammatory response) has also been noted in patients suffering from Long COVID. 30 (8) Platelet hyperactivation is a key feature of a hypercoagulable state and has also been noted as a prominent feature in the pathobiology of acute infection 68 69 and Long COVID. 71 Created with BioRender.com. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; ED, endothelial dysfunction; ICAM1, intercellular adhesion molecule 1; PAI-1, plasminogen activator inhibitor 1; RAS, renin–angiotensin system; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TF, tissue factor; VCAM1, vascular cell adhesion molecule 1; VWF, Von Willebrand factor.

Recap A Perspective on How Fibrinaloid Microclots and
Platelet Pathology May be Applied in Clinical
Investigations
@dbkell.bsky.social et al
www.thieme-connect.com/products/ejo...
@davidjoffe64.bsky.social et al
pmc.ncbi.nlm.nih.gov/articles/PMC...

Pleased to see our paper on #preeclampsia and cell #senescence and seeming prevention by #ergothioneine is now published, with @resiapretorius.bsky.social @louiseckenny.bsky.social @lorenkell.bsky.social @themoorelab.bsky.social and others doi.org/10.1016/j.jr.... Hope we can get RCTs done now.

Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria Antimicrobial resistance is a massive threat, but it can take decades to develop a new antibiotic. That time could be drastically reduced if we were able to anticipate desirable properties of a chemic...

New preprint on the antibacterial mode of action of colistin www.biorxiv.org/content/10.1...

AmyloGram Reveals Amyloidogenic Potential in Stroke Thrombus Proteomes Background: Amyloidogenic proteins play a central role in a range of pathological conditions, yet their presence in thrombi has only recently been recognized. Whether computational prediction tools ca...

New bioinformatics preprint w bsky.app/profile/resi... and others on the amyloid nature of the thrombus (clot) proteome in ischaemic stroke www.biorxiv.org/content/10.1... #TeamClots

www.biorxiv.org/content/10.1... New preprint on proteins involved in colistin sensitivity/resistance #AMR

A new review with
@resiapretorius.bsky.social on two more imaging methods for measuring effects of #fibrinaloid #microclots on the #microcirculation and endothelial damage. #TeamClots #pwLC #pwME preprints.org/manuscript/2.... Much pricier than #nailfold #capillaroscopy but impactful.

‘I could hear the Camerons sniggering at us’ – Sarah Vine’s How Not to Be a Political Wife, digested by John Crace Michael Gove’s ex on her compassionate pieces for the Daily Mail, struggling to survive on an MP’s salary, doing Sam Cam’s ironing and becoming a laughing stock after Brexit

johncrace right on the button when analysing these ghastly people who destroyed the UK www.theguardian.com/books/2025/j...

@resiapretorius.bsky.social @dbkell.bsky.social @ruhoy.bsky.social @kaufmanmd.bsky.social @putrinolab.bsky.social @virusesimmunity.bsky.social

Documentary "Chronically Ignored", 92 min, now via online stream, just 14 days. Unfortunately with payment, but I'd be grateful for watching & sharing ♥️

@dbkell.bsky.social

The MAHA Report Cites Studies That Don’t Exist The Trump administration’s “Make America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.

More idiotic incompetence... www.notus.org/health-scien...

Another new preprint with
@resiapretorius.bsky.social
is available, on a technique called #Nailfold #Capillaroscopy that we think will be an important complement to #microclot measurements. preprints.org/manuscript/2... #TeamClots

Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance | Stroke

🧠 Daily Feed of Brain Damage 🧠

Part 2

Sincerest thanks to @resiapretorius.bsky.social and @dbkell.bsky.social

www.ahajournals.org/doi/10.1161/...

Screenshot of this study intro

ME/CFS Incidence Is Higher Following COVID-19

"Other studies have shown that many acute viral, bacterial, and protozoal illnesses can be followed by ME/CFS — including COVID-19. This study highlights the clinical similarity between #MECFS and #longCOVID — the two..."

www.jwatch.org/na58371/2025...

Jeff Bridges says he’s ‘feeling good’ nearly 5 years after cancer diagnosis, but dealing with ‘long-term’ Covid effects | CNN Jeff Bridges is sharing some good news pertaining to his health.

“My dance with #COVIDー19 makes my cancer look like a piece of cake.” #LongCOVID - Jeff Bridges

www.cnn.com/2025/05/10/e...

Next, I’d like to address 🇨🇦 + 🌍 countries -

You must establish:

- There is no white genocide in South Africa.

- The video Trump showed to the South African President was from the Congo and previously published by Reuters on Feb 3, 2025.

- Trump did this knowingly and intentionally.

Trump Bans International Students at Harvard in Horrifying Move This will hurt so many students—and destroy Harvard.

Shameful. #EduSky #AcademicSky

Our paper with @bsky.resiapretorius.social relating #BloodStasis in #TCM to fibrinaloid #microclots formation is published in full form #OpenAccess at www.mdpi.com/1424-8247/18... #TeamClots @livuniresearch.bsky.social

I am giving a talk on #LongCovid and #MECFS at this event on May 22 www.tickettailor.com/events/clini... but note that tickets are not (at all) free, I'm afraid. #TeamClots

Pleased that the paper on #TCM and #Microclots and blood stasis with
@resiapretorius.bsky.social
preprinted at preprints.org/manuscript/2... has just been accepted for full publication. #TeamClots

Not yet. We are hoping one will soon start (I am not involved directly but gave advice, freely). I am in touch with Vlad (more accurately his partner).

YouTube video by Garys Economics Meeting Gary's favourite economist: Ha-Joon Chang

www.youtube.com/watch?v=MGt7...

Prima Facie - Liverpool Everyman & Playhouse Theatres

Hoping to see the brilliant #jodiecomer but it's sold out a year away! everymanplayhouse.com/event/prima-...

A screenshot from the letter from ME researchers to funders over at https://psp-me.co.uk/campaign-strategic-approach-mecfs-research/. It reads: "MRC and NIHR have awarded £7.34m in ME/CFS research since 2013, including £3.2m to DecodeME (link). This is just £2.67 per person with ME (pwME) per year. Charities fund just under £2 per pwME per year (link). This compares with the UK’s annual spend of £74 per person on health research (link). Despite being at least twice as prevalent, ME/CFS receives approximately 20-times less research funding than multiple sclerosis (link). ME/CFS’s annual cost to the UK economy is at least £3.3 billion (link); the cost of Long Covid to UK GDP is £1.5 billion annually (link)." (Sorry, none of the links were actual links in the source document so I cannot share their sources with you) (I also note they quote the ancient and incorrect prevalence figure of 250k in the same letter so presumably the amount per person is even less!)

A screenshot from the letter from ME researchers to funders over at https://psp-me.co.uk/campaign-strategic-approach-mecfs-research/. It reads: "A recent application to the highlight notice, having taken into account advice from academic experts, UKRI funders and PPI groups about the imperative to align and synergise molecular pathogenesis approaches across both ME/CFS and Long Covid, and from an internationally recognised team with multiple relevant, recent publications in Science, Nature and Lancet, was declined with one referee allocating a score of ‘1/6; poor’. Another research team with a similar output profile has shelved all plans to work on ME/CFS after four attempts to obtain funding since 2020. Each application was revised in line with the feedback but then compromised by highly inappropriate reviews, two of which indicated that the reviewer had not read the grant (e.g., by criticizing experiments that were not proposed anywhere in the application), and one of which indicated that the reviewer had little or no relevant knowledge (e.g., by stating that there is a universal treatment for ME/CFS). Other reviews used earlier published research with conclusions based on highly questionable data to criticize the validity of the approach, which had already pinpointed a molecular signature of ME/CFS. This work remains unpublished without funds needed to push it through to completion." No prizes for guessing what the 'earlier published research with conclusions based on highly questionable data' is either. This feels very systemic and also shows the levels of gaslighting from our government regarding their delivery plan - they've suggested they just need to encourage more research grant proposals and that will fix it. But when good grant proposals are being turned down like this by Wessely and co, that just won't cut it.

Signatories include @daltmann.bsky.social , @claguenjc36.bsky.social, @dbkell.bsky.social and @cgatist.bsky.social - Thank you so much for this!!

The letters do not mince their words either which by now is the only way to talk about M.E. if you ask me.

A big day for many Long Cövid collaborators.
@resiapretorius.bsky.social @dbkell.bsky.social @drgrahamlj.bsky.social @putrinolab.bsky.social

Our Endotheliitis paper won a prestigious award 🥂🙏🏻

doi.org/10.1055/s-00...

🧪 Gez Medinger talks to @resiapretorius.bsky.social &
@dbkell.bsky.social
(also Many #TeamClots
links
dbkgroup.org/longcovid/)
Part 1
Doug kell microclots
youtu.be/2Q2tf9E3kzw?...

Part 2 nattokinase
youtu.be/6q2WS4NuiBQ?...

Part 3
Microclots treatments
Jack Laubscher
youtu.be/vWisaTFp4KI?...

Trying to rebuild my #NEISvoid and #ChronicIllness communities here! This starter pack looks helpful for anyone else trying to do the same:

go.bsky.app/GcGzAae

New preprint with @resiapretorius.bsky.social, @louiseckenny.bsky.social et al. on Cellular #senescence, #preeclampsia and #ergothioneine www.preprints.org/manuscript/2...

Interesting juxtaposition at bbc.co.uk/news/article...: