Douglas Kell

Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. Preprint with @resiapretorius www.preprints.org/manuscript/2... #preprints via @Preprints_org #TeamClots

Thames Water want to pollute illegally until 2040. Ofwat must say NO. Thames water want to make at deal with Ofwat, to pollute illegally for 15 years

🚨Urgent: Thames Water want permission from Ofwat to ILLEGALLY pollute rivers and seas until 2040.

🤮They want your bills to fill their pockets with gold, while they fill your rivers with sewage.

✍️Sign now. Tell Ofwat to say NO to Thames Water before Tuesday 21st October.

Most viruses seem to get more transmissible but less virulent as a pandemic evolves, and that is true for SARS-CoV-2. Of course some folk get MORE susceptible after every infection. Itt is far from over.

#tinnitus is a frequent symptom for #pwLC, #pwME and others. @resiapretorius.bsky.social and I think the evidence is strong (and self-consistent) that it is often caused by #microclots and summarise it at www.preprints.org/manuscript/2... #TeamClots

YouTube video by Jillian Angeline "Get rid of the microclots" | Will 2 Win: Overcoming Long COVID with Jillian Angeline

May be of interest to #pwLC and #pwME www.youtube.com/watch?v=H-NX... #TeamClots

#Medsky🧪 #IDsky #Immunosky #publichealth
Recent research has shown that human plasmacytoid dendritic cells (pDCs) have been altered by #SARSCoV2 🦠This could have implications for both viral persistence and the development of #LongCOVID, with the Omicron subvariants having a more prominent effect.

Ferritin in plasma is not in fact a marker of iron deficiency. dbkgroup.org/Papers/kell_...

New preprint with @resiapretorius.bsky.social showing the amyloidogenic potential of the proteome of thrombi in various embolisms and atherosclerotic plaques. #TeamClots www.preprints.org/manuscript/2...

My chum reminds me: "The England India cricket series was a day longer than Liz Truss's premiership in duration (46 days from start to finish). Far more enjoyable, exciting, happy and socially more cohesive." Too right.

1/
Many of us who developed #LongCOVID in the first wave in 2020, noticed an abrupt change in our nails -

@resiapretorius.bsky.social
Via @dbkell.bsky.social

www.preprints.org/manuscript/2...

(A to F) Whole blood scanning electron microscopy of micrograph data previously collected in published studies. (A) A few plasma deposits are discernible within the blood sample of a healthy participant 173 ; (B) systemic lupus erythematosus174; (C and D) acute COVID-19 during the initial wave in 202030; (E) rheumatoid Arthritis; (F) Alzheimer's-type disease. 176

COVID-associated endothelial dysfunction and endothelialitis. Schematic representation of COVID-associated ED and endothelialitis. (1) Under pathological conditions, Type I and Type II endothelial activation—together with endothelial cell injury, such as endothelial cell apoptosis and necrosis—are all involved in ED. 39 (2) Endothelial activation promotes the production of various cytokines, chemokines, and other biomolecules that are involved in coagulation and the immune response. 40 (3) Viral persistence may contribute to ongoing endothelial inflammation or ED in Long COVID. 87 88 (4) After invasion of the endothelial cells by the virus, P-selectin, TF, ICAM1, VCAM1, and PAI-1 are expressed on these cells and ultra-large VWF multimers are also released. 58 (5) The downregulation of ACE2 favors ED 39 135 136 137 and leads to (6) a dysregulated local RAS with increased levels of Angiotensin II. 55 (7) Capillary rarefication (indicating an inflammatory response) has also been noted in patients suffering from Long COVID. 30 (8) Platelet hyperactivation is a key feature of a hypercoagulable state and has also been noted as a prominent feature in the pathobiology of acute infection 68 69 and Long COVID. 71 Created with BioRender.com. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; ED, endothelial dysfunction; ICAM1, intercellular adhesion molecule 1; PAI-1, plasminogen activator inhibitor 1; RAS, renin–angiotensin system; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TF, tissue factor; VCAM1, vascular cell adhesion molecule 1; VWF, Von Willebrand factor.

Recap A Perspective on How Fibrinaloid Microclots and
Platelet Pathology May be Applied in Clinical
Investigations
@dbkell.bsky.social et al
www.thieme-connect.com/products/ejo...
@davidjoffe64.bsky.social et al
pmc.ncbi.nlm.nih.gov/articles/PMC...

Pleased to see our paper on #preeclampsia and cell #senescence and seeming prevention by #ergothioneine is now published, with @resiapretorius.bsky.social @louiseckenny.bsky.social @lorenkell.bsky.social @themoorelab.bsky.social and others doi.org/10.1016/j.jr.... Hope we can get RCTs done now.

Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria Antimicrobial resistance is a massive threat, but it can take decades to develop a new antibiotic. That time could be drastically reduced if we were able to anticipate desirable properties of a chemic...

New preprint on the antibacterial mode of action of colistin www.biorxiv.org/content/10.1...

AmyloGram Reveals Amyloidogenic Potential in Stroke Thrombus Proteomes Background: Amyloidogenic proteins play a central role in a range of pathological conditions, yet their presence in thrombi has only recently been recognized. Whether computational prediction tools ca...

New bioinformatics preprint w bsky.app/profile/resi... and others on the amyloid nature of the thrombus (clot) proteome in ischaemic stroke www.biorxiv.org/content/10.1... #TeamClots

www.biorxiv.org/content/10.1... New preprint on proteins involved in colistin sensitivity/resistance #AMR

A new review with
@resiapretorius.bsky.social on two more imaging methods for measuring effects of #fibrinaloid #microclots on the #microcirculation and endothelial damage. #TeamClots #pwLC #pwME preprints.org/manuscript/2.... Much pricier than #nailfold #capillaroscopy but impactful.

‘I could hear the Camerons sniggering at us’ – Sarah Vine’s How Not to Be a Political Wife, digested by John Crace Michael Gove’s ex on her compassionate pieces for the Daily Mail, struggling to survive on an MP’s salary, doing Sam Cam’s ironing and becoming a laughing stock after Brexit

johncrace right on the button when analysing these ghastly people who destroyed the UK www.theguardian.com/books/2025/j...

@resiapretorius.bsky.social @dbkell.bsky.social @ruhoy.bsky.social @kaufmanmd.bsky.social @putrinolab.bsky.social @virusesimmunity.bsky.social

Documentary "Chronically Ignored", 92 min, now via online stream, just 14 days. Unfortunately with payment, but I'd be grateful for watching & sharing ♥️

@dbkell.bsky.social

The MAHA Report Cites Studies That Don’t Exist The Trump administration’s “Make America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.

More idiotic incompetence... www.notus.org/health-scien...

Another new preprint with
@resiapretorius.bsky.social
is available, on a technique called #Nailfold #Capillaroscopy that we think will be an important complement to #microclot measurements. preprints.org/manuscript/2... #TeamClots

Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance | Stroke

🧠 Daily Feed of Brain Damage 🧠

Part 2

Sincerest thanks to @resiapretorius.bsky.social and @dbkell.bsky.social

www.ahajournals.org/doi/10.1161/...

Screenshot of this study intro

ME/CFS Incidence Is Higher Following COVID-19

"Other studies have shown that many acute viral, bacterial, and protozoal illnesses can be followed by ME/CFS — including COVID-19. This study highlights the clinical similarity between #MECFS and #longCOVID — the two..."

www.jwatch.org/na58371/2025...

Jeff Bridges says he’s ‘feeling good’ nearly 5 years after cancer diagnosis, but dealing with ‘long-term’ Covid effects | CNN Jeff Bridges is sharing some good news pertaining to his health.

“My dance with #COVIDー19 makes my cancer look like a piece of cake.” #LongCOVID - Jeff Bridges

www.cnn.com/2025/05/10/e...

Next, I’d like to address 🇨🇦 + 🌍 countries -

You must establish:

- There is no white genocide in South Africa.

- The video Trump showed to the South African President was from the Congo and previously published by Reuters on Feb 3, 2025.

- Trump did this knowingly and intentionally.

Trump Bans International Students at Harvard in Horrifying Move This will hurt so many students—and destroy Harvard.

Shameful. #EduSky #AcademicSky

Our paper with @bsky.resiapretorius.social relating #BloodStasis in #TCM to fibrinaloid #microclots formation is published in full form #OpenAccess at www.mdpi.com/1424-8247/18... #TeamClots @livuniresearch.bsky.social

I am giving a talk on #LongCovid and #MECFS at this event on May 22 www.tickettailor.com/events/clini... but note that tickets are not (at all) free, I'm afraid. #TeamClots

Pleased that the paper on #TCM and #Microclots and blood stasis with
@resiapretorius.bsky.social
preprinted at preprints.org/manuscript/2... has just been accepted for full publication. #TeamClots

Not yet. We are hoping one will soon start (I am not involved directly but gave advice, freely). I am in touch with Vlad (more accurately his partner).