The Microflora Danica atlas of Danish environmental microbiomes - Nature Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Denmark just mapped its entire environmental microbiome. More than 10,000 samples revealing hidden, dominant nitrifiers that shape fertilizer use, water quality, and climate impact. A national microbiome atlas could transform sustainable agriculture across Europe.
#AMR
www.nature.com/articles/s41...

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

Covid inquiry live updates: UK did 'too little, too late', leading to thousands more Covid deaths, says inquiry The inquiry says an earlier lockdown could have saved 23,000 lives in the first wave in England - and lockdown could have been avoided altogether with earlier interventions.

Confiner une semaine plus tôt aurait permis d'éviter 23 000 décès pendant la 1ère vague de #Covid19 en Angleterre, soit la moitié du total, selon une modélisation.

Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.

1/3

This garbage is what we’re up against.

I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.

These bottom-feeding influencer scum are preying on the desperate.

Small things matter: Lack of extraislet β cells in type 1 diabetes Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.

Open access link to new study in Science Advances:

Small things matter: Lack of extraislet β cells in type 1 diabetes.

🧪 #medsky
www.science.org/doi/10.1126/...

Dark genome holds clues to Neanderthal face shape | Institute of Genetics and Cancer | Institute of Genetics and Cancer Differences in a specific region of the Neanderthal genetic code may have contributed to their distinctive protruding jawline, a study suggests.

Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social

In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells.

doi.org/10.1016/j.stem.2020.09.001

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

I am on a quest to follow all the Bioinformaticians here on #Bluesky.

Rhymes with Haystack | Albert | Substack Biotech, Next Generation Sequencing, Single cell and Spatial Biology, Next Generation Proteomics, Synthetic Biology, Small Molecules and Biologics pharma, and related topics. Click to read Rhymes with...

I am a Bioinformatics Scientist and write about: Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, Compute Acceleration in biotech // long-form posts at albertvilella.substack.com

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...

Toward Same-Day Genome Sequencing in the Critical Care Setting | New England Journal of Medicine www.nejm.org/doi/full/10....

Awesome re-analysis of the Franklin / Crick / Watson story. Explains how Franklin produced (with considerable skill) the *pictures* that made the penny drop for slow-on-the-uptake Watson. Sadly, paywalled.

www.cambridge.org/core/journal...

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...

Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.

In a new preprint, we share some clues about when, how, and why this happens!

www.biorxiv.org/content/10.1...

Why I gave the world wide web away for free | Tim Berners-Lee My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for

Tim Berners-Lee: Why I gave the world wide web away for free.

"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."

🧪💻🛜
www.theguardian.com/technology/2...

Cerebellar Contributions to Action and Cognition: Prediction, Timescale, and Continuity The cerebellum is implicated in nearly every domain of human cognition, yet our understanding of how this subcortical structure contributes to cognition remains elusive. Efforts on this front have ten...

The cerebellum isn’t just about coordinating movement. It’s implicated in nearly every domain of cognition—from language to social behavior.

But how exactly does the cerebellum contribute to action and cognition? 🧵

Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818

EMBO Molecular Medicine: Vol 17, No 9 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our September issue is online! www.embopress.org/toc/17574684...

On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...

Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

Ce que les pleurs de bébé nous disent vraiment – et pourquoi l’instinct maternel est un mythe Est-il possible de traduire les pleurs des bébés pour comprendre avec exactitude leurs besoins ?

👶 On ne naît pas parent, on le devient. Comme l'expérimentent celles et ceux qui volent au secours de leur progéniture lorsque leurs #cris de détresse retentissent. Explications de @nicolasmathevon.bsky.social
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...

Remembering A. James Hudspeth, hair cell explorer Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

A. James Hudpseth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

By @callimcflurry.bsky.social

www.thetransmitter.org/hearing/reme...

Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome - Nature Communications This study identified prevalent giant extrachromosomal elements from the human oral microbiome. The genetic and ecological analysis provides insight on the potential contribution of this element in ad...

We are happy to announce that our latest manuscript has been published in Nature Communications! We identified the highly abundant and prevalent (>70% in population) giant (Max. 395kb) extrachromosomal element in the human mouth, named "Inocle".
www.nature.com/articles/s41...

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪

I fail to understand the value of using epigenetic aging clocks in any situation.

They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.

More expensive and less meaningful than a fortune telling machine.

Parlement européen : la motion de censure contre Ursula von der Leyen largement rejetée La présidente de la Commission européenne est parvenue à préserver la confiance d’une majorité de députés à Strasbourg, malgré des tensions au sein du camp «pro-européen».

Parlement européen : la motion de censure contre Ursula von der Leyen largement rejetée

www.lefigaro.fr/internationa...

How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.

Reading:

How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

A simple path, followed by an equation.
Basic research leads to knowledge, which leads to nonprofitable ideas, which leads to profitable ideas, which leads to commercial products, which leads to jobs, which fuels the economy.

Kill research=kill the economy

Somewhere, something incredible is waiting to be known.

Somewhere, something incredible is waiting to be known.

Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2
@jci-insight.bsky.social
insight.jci.org/articles/vie...