AMR, antibiotic use increasing | Pharmacy Daily ANTIBIOTIC prescriptions in Australia have increased, antibiotic resistance is on the up, and less than half the antibiotics given after surgeries were appropriate, according to the Australian Centre ...

Antibiotic use in Australia is lower than a decade ago, and hospitals use last-line antibiotics carefully. However, rising #AMR and inconsistent prescribing, especially after surgery and in geriatrics, highlight the need to strengthen antimicrobial stewardship.
pharmacydaily.com.au/news/amr-ant...

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.

faculty-einstein.icims.com/jobs/17847/a...

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era - Nature Reviews Microbiology In this Review, Castañeda-Barba, Top and Stalder use the One Health framework to synthesize the recent literature on the ecological and evolutionary factors that determine the successful local and glo...

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era - www.nature.com/articles/s41...

The way to accelerate science is to SLOW it down.

Fewer papers please! We’re drowning in meaningless text.

One GREAT paper per lab per decade is more than enough.

q.e.d 👇

Like the genetic code, bitcoin, or national borders, our methods for evaluating science are a "frozen accident": things that were formed from historical circumstances rather than careful design, and that persist not because they are optimal, but because replacing them is extraordinarily difficult.

Why we must act now on tackling antimicrobial resistance Antimicrobial resistance threatens our health and economic security. Organizations are urged to sign the Davos Compact on AMR to tackle this global threat.

#AMR is a prominent topic at the World Economic Forum Annual Meeting 2026 this week in Davos, where leaders are advancing the Davos Compact on AMR and calling for urgent, coordinated action on innovation, stewardship, sustainable agriculture, and financing.

www.weforum.org/stories/2026...

And my group at the Centre for Emerging Viral Diseases is also hiring: We are looking for a postdoc for our work on mucosal immunity and respiratory viruses!

jobs.unige.ch/www/wd_porta...

YouTube video by John Greally Epigenetics: History, Molecules, and Diseases -- Book overview

I finally got around to putting together a quick overview of what my book is all about.

youtu.be/xPt1xy4_i-o?...

#epigenetics #epigeneticsbook #epigenome

The Microflora Danica atlas of Danish environmental microbiomes - Nature Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Denmark just mapped its entire environmental microbiome. More than 10,000 samples revealing hidden, dominant nitrifiers that shape fertilizer use, water quality, and climate impact. A national microbiome atlas could transform sustainable agriculture across Europe.
#AMR
www.nature.com/articles/s41...

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

Covid inquiry live updates: UK did 'too little, too late', leading to thousands more Covid deaths, says inquiry The inquiry says an earlier lockdown could have saved 23,000 lives in the first wave in England - and lockdown could have been avoided altogether with earlier interventions.

Confiner une semaine plus tôt aurait permis d'éviter 23 000 décès pendant la 1ère vague de #Covid19 en Angleterre, soit la moitié du total, selon une modélisation.

Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.

1/3

This garbage is what we’re up against.

I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.

These bottom-feeding influencer scum are preying on the desperate.

Small things matter: Lack of extraislet β cells in type 1 diabetes Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.

Open access link to new study in Science Advances:

Small things matter: Lack of extraislet β cells in type 1 diabetes.

🧪 #medsky
www.science.org/doi/10.1126/...

Dark genome holds clues to Neanderthal face shape | Institute of Genetics and Cancer | Institute of Genetics and Cancer Differences in a specific region of the Neanderthal genetic code may have contributed to their distinctive protruding jawline, a study suggests.

Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social

In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells.

doi.org/10.1016/j.stem.2020.09.001

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

I am on a quest to follow all the Bioinformaticians here on #Bluesky.

Rhymes with Haystack | Albert | Substack Biotech, Next Generation Sequencing, Single cell and Spatial Biology, Next Generation Proteomics, Synthetic Biology, Small Molecules and Biologics pharma, and related topics. Click to read Rhymes with...

I am a Bioinformatics Scientist and write about: Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, Compute Acceleration in biotech // long-form posts at albertvilella.substack.com

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...

Toward Same-Day Genome Sequencing in the Critical Care Setting | New England Journal of Medicine www.nejm.org/doi/full/10....

Awesome re-analysis of the Franklin / Crick / Watson story. Explains how Franklin produced (with considerable skill) the *pictures* that made the penny drop for slow-on-the-uptake Watson. Sadly, paywalled.

www.cambridge.org/core/journal...

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...

Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.

In a new preprint, we share some clues about when, how, and why this happens!

www.biorxiv.org/content/10.1...

Why I gave the world wide web away for free | Tim Berners-Lee My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for

Tim Berners-Lee: Why I gave the world wide web away for free.

"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."

🧪💻🛜
www.theguardian.com/technology/2...

Cerebellar Contributions to Action and Cognition: Prediction, Timescale, and Continuity The cerebellum is implicated in nearly every domain of human cognition, yet our understanding of how this subcortical structure contributes to cognition remains elusive. Efforts on this front have ten...

The cerebellum isn’t just about coordinating movement. It’s implicated in nearly every domain of cognition—from language to social behavior.

But how exactly does the cerebellum contribute to action and cognition? 🧵

Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818

EMBO Molecular Medicine: Vol 17, No 9 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our September issue is online! www.embopress.org/toc/17574684...

On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...

Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

Ce que les pleurs de bébé nous disent vraiment – et pourquoi l’instinct maternel est un mythe Est-il possible de traduire les pleurs des bébés pour comprendre avec exactitude leurs besoins ?

👶 On ne naît pas parent, on le devient. Comme l'expérimentent celles et ceux qui volent au secours de leur progéniture lorsque leurs #cris de détresse retentissent. Explications de @nicolasmathevon.bsky.social
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...

Remembering A. James Hudspeth, hair cell explorer Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

A. James Hudpseth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

By @callimcflurry.bsky.social

www.thetransmitter.org/hearing/reme...

Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome - Nature Communications This study identified prevalent giant extrachromosomal elements from the human oral microbiome. The genetic and ecological analysis provides insight on the potential contribution of this element in ad...

We are happy to announce that our latest manuscript has been published in Nature Communications! We identified the highly abundant and prevalent (>70% in population) giant (Max. 395kb) extrachromosomal element in the human mouth, named "Inocle".
www.nature.com/articles/s41...

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪