Andrew Monteith

Infections as ecosystems: community metabolic interactions in microbial pathogenesis | Infection and Immunity Microbial communities are present on nearly every surface of the human body. These microbiomes exist as dynamic ecosystems that are influenced by heterogeneous nutritional and chemical landscapes, the...

Excited to have our new mini review on Microbiome Metabolism out today in I&I as part of the @asm.org New Voices in Microbiology collection! Check it out!

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journals.asm.org/doi/10.1128/...

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a s...

Happy to share Iván’s first-author pub from the lab! www.cell.com/cell-reports...

Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity Cell metabolism plays a key role in shaping immune cell differentiation and function, with each immune cell subset depending on distinct metabolic pathways. While there have been extensive studies and...

Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen

A successful collaboration across borders, and hopefully, the first of many!

Happy you were willing to help us! Looking forward to our next multi-lab collaboration here at @utkmicrobiology.bsky.social

Mitochondria sense bacterial lactate and drive release of neutrophil extracellular traps Historically, neutrophil mitochondria were overlooked as they do not contribute to energy homeostasis. Wise et al. reveal that neutrophil mitochondria can sense bacterial persistence in the phagosome ...

The debut paper from the lab is live! Check out the amazing work by @ashleydwise.bsky.social and collaborators discovering that mitochondria are not just the 'powerhouse of the cell' but adapted by neutrophils to sense bacterial persistence and trigger NETosis.

www.cell.com/cell-host-mi...

Diabetes potentiates the emergence and expansion of antibiotic resistance Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.

Delighted to share our new study. A collaboration with the Thurlow lab. Antibiotic resistance rapidly emerges and thrives in diabetic mice. A worrying coming together of two major and growing health problems worldwide www.science.org/doi/10.1126/...