UPENN_ITMAT

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

Two needs one deed: #MoodDisorders & #ChronicPain alleviated by single-agent therapeutic approach. More in doi.org/10.1038/s415... #Psilocybin @jmcichon #MentalHealth #Anxiety #Depression #TranslationalScience

Novel MEPAN #MouseModel recapitulating #HumanPhenotype of #MovementDisorder, #OpticNeuropathy, defects in protein #Lipoylation, & reduced mitochondrial #OxidativePhosphorylation in the #Brain doi.org/10.1073/pnas... #MitochondrialMedicine #TranslationalScience

BTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1,000s of omics datasets AbstractMotivation. Summary statistics from genome-wide association studies (GWAS) are widely used in fine-mapping and colocalization analyses to identify

Scalable algorithms integrating #FunctionalGenomics with #GWAS results: doi.org/10.1093/bioi... @lisanwang @PNGC_UPENN #ImmuneSystem #Cardiovascular

How is #BrainDevelopment linked to the emergence of #MentalHealthDisorders? Harmonizing & sharing #Neuroimaging data & well-defined psychiatric phenotypes are essential building blocks to pursue answers: doi.org/10.1016/j.ne... @sattertt @pennlinc.bsky.social #TranslationalScience

Novel immunological states characterize the #Glioma landscape with #Prognostic value doi.org/10.1093/neuo... @Amankulor_Lab #CancerResearch #BrainTumor #Immunogenetics #SingleCell #TranslationalScience

Mechanistic insight into #BowelDisease: Mechanically stressed intestinal smooth muscle cells alter #GeneTranscription towards #Inflammation insight.jci.org/articles/vie... @HeoLab #MechanoBiology #InflammatoryBowelDisease #Chrons #Colitis #TranslationalScience

Circadian Control of Pulmonary Endothelial Signaling Occurs via the NADPH Oxidase 2-NLRP3 Pathway - Shaon Sengupta, Yool Lee, Jian Qin Tao, Isha Akolia, Natalia Louneva, Kaitlyn Forrest, Oindrila Paul... Circadian rhythms are endogenous oscillations that occur with a 24-h periodicity and support organismal homeostasis. While the role of the circadian clock in sy...

Elucidating the bidirectional relationship between #CircadianClock & #Inflammation involving specific #MolecularPathways such as NOX2 in #PulmonaryVasculature journals.sagepub.com/doi/10.1177/... @SenguptaShaon #NLRP3 #TranslationalScience

Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology This study examines associations between fine particulate matter air pollution exposure, dementia severity, and dementia-associated neuropathologic change.

Examining environmental factors potentially linked to disease expression in Alzheimer Disease jamanetwork.com/journals/jam... @tnrlab.bsky.social #Alzheimers #Dementia #MentalHealth #Brain #AirQuality #AirPollution #TranslationalScience

Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome Pharmacological recovery of mitochondrial function improves blood-brain barrier function and cognition in 22q11.2 deletion syndrome, a risk factor for schizophrenia.

Characterizing the role of #Mitochondria in the #BloodBrainBarrier (BBB) & how impaired #MitochondrialFunction within the BBB relates to disease expression doi.org/10.1126/scit... #Neuroscience #TranslationalScience

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Allogeneic #StemCell -derived islet- #CellTherapy as a candidate to restore physiologic #IsletFunction www.nejm.org/doi/10.1056/... #DiabetesResearch #Diabetes #T1D #IsletBiology #TranslationalScience

Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion Author summary All mammals have a unique class of genes that are crucial for normal growth, known as “imprinted genes,” where only one gene copy inherited from a parent is active. Imprinted genes are ...

Igf2/H19 locus as instructive model to study how allele-specific #GenomeArchitecture facilitates enhancer-promoter interaction that dictate tissue-specific #GeneExpression in #SkeletalMuscle doi.org/10.1371/jour... @Marisa_S_B #TranslationalScience

Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity - Nature Communications Scaffolding protein ankyrin-B, implicated in cardiometabolic syndrome, enables mitochondrial fission and flexibility of nutrient utilization under energetic stress in skeletal muscle to support energy...

Discovery of a novel #MolecularPathway to maintain high levels of #PhysicalActivity doi.org/10.1038/s414... @thelorenzolab #Mitochondria #EnduranceExercise #TranslationalScience

Molecular insights to potentially prevent #BetaCell failure in #Type2Diabetes doi.org/10.1016/j.mo... #T2D #DiabetesResearch #IsletBiology #TranslationalScience

#Epigenetics modulation of the topography of #AlzheimerDisease pathology linked to #AtypicalAD presentations doi.org/10.1016/j.ne... #Aging @alzassociation @AlzSocResearch @TheADDF #Alzheimers #Dementia #MentalHealth #Brain #TranslationalScience

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape - Nature Nanotechnology Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA-lipid nanoparticles while enabling high RNA expression.

Translating therapeutic modalities of #LipidNanoparticles to disease indications with pre-existing inflammation www.nature.com/articles/s41... @jakebrenner #LNPs #Nanomedicine #DrugDevelopment #TranslationalScience

The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.

Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism www.nature.com/articles/s41... @ksusztak.bsky.social‬ #TranslationalScience

Deficient #AMPK signaling in AT2 cell dysfunction as druggable signaling hub to mitigate #LungFibrosis in vivo insight.jci.org/articles/vie... #DrugDevelopment #PulmonaryResearch #TranslationalScience

Mouse reporter model to study #MuscleCell contribution during #BoneFracture repair reveals novel mechanism doi.org/10.1073/pnas... @LingQin6 #RegenerativeMedicine #TranslationalScience

Individuals w/ #BMAL1 variants share #DevelopmentalDelay, #AutismSpectrumDisorder, #SleepDisturbances, #Seizure, #MarfanoidHabitus as clinical symptomatology w/ mechanistic links to disrupted BMAL1 function doi.org/10.1073/pnas... @amitaseh #TranslationalScience

Cardiotropic #DrugDelivery system: Proof-of-concept for #LipidNanoparticles targeting cardiomyocyte-specific SERCA2A to modulate contractility & relaxation www.pnas.org/doi/10.1073/... #siRNA #Myocardium #TranslationalScience

#Neuropeptides essential for complex social behavior with phenotypic plasticity in social insect model doi.org/10.1016/j.ce... #SocialAnalysis #SocialHierarchy #TranslationalScience

Join us via Zoom!
Register Here: tinyurl.com/virtualTRIPICA

Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences | Circulation BACKGROUND: Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular ...

Penn Medicine #BioBank growing its impact: Discerning early aortic #aging from imaging data with links to adverse #CardiacRemodeling and poor #CardiovascularOutcomes www.ahajournals.org/doi/10.1161/... @ThePMBioBank #PMBB #TranslationalScience

You’re Invited: Where Science Meets Art: ITMAT Artist-in-Residence Ceramic Showcase on 7/24 from 5-7 PM at the Institute for Contemporary Art in Philadelphia, PA!
RSVP at www.instagram.com/upenn_itmat/

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies Objective Aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB.....

Developing biomarkers to differentiate between #Parkinsons disease (PD) and dementia with #LewyBodyDisease: Implications for #α-synuclein (aSyn) misfolding & aggregation doi.org/10.1002/ana.... @alicechenplotkin.bsky.social‬ #NeuroDegeneration #Neurology #TranslationalScience

Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder Maroni et al. examine the effects of partial loss of the histone lysine methyltransferase DOT1L on neuronal development and function. Using zebrafish and m

Discerning underlying mechanisms linking loss in the methyltransferase DOT1L activity to #NeurodevelopmentalDisorders (#NDDs) doi.org/10.1093/brai... #MentalHealth #Neurology #TranslationalScience

#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.... #MentalHealth #TranslationalScience

In vivo CAR T cell generation to treat cancer and autoimmune disease Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...

Broadening clinical utility of #CARTcelltherapy through in vivo engineering targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets doi.org/10.1126/scie... @carlhjune @Haig_Ag #CellTherapy #CARTCell #TranslationalScience

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Exploring the potential to restore physiologic islet function through fully differ¬entiated, allogeneic pluripotent stem cell–derived islet-cell therapy for #Type1Diabetes www.nejm.org/doi/10.1056/... #StemCell #CellTherapy #TranslationalScience