Afroze Chimthanawala

Epitranscriptomic control of stress adaptations in Escherichia coli Abstract. The impacts of various stressors on bacterial systems have been studied at the phenotypic, transcriptional, and translational levels during the e

🦠💫 RNA modifications and stress

04.02.2026 09:27 — 👍 6    🔁 1    💬 0    📌 0

Abstract deadline for the SMBio26 organized with the University of Sheffield, is postponed to February 27th to accommodate for extra spots made available!

To accommodate for extra spots made available, we're reopening the abstract deadline for the SMBio26 organized together with the University of Sheffield!

Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters.

Program & registration 👉 bit.ly/3NtxZlM

04.02.2026 15:56 — 👍 2    🔁 1    💬 0    📌 0

Dynamic RNA Polymerase compartments organize the transcription of gene clusters https://www.biorxiv.org/content/10.64898/2026.01.07.698080v1

08.01.2026 14:32 — 👍 2    🔁 3    💬 0    📌 0

Hey alpha aficionados - it's almost time for CauloCon 2026! This free, virtual meeting will feature talks from @brunlabcaulo.bsky.social @thanbichlerlab.bsky.social and @lamasonlab.bsky.social with opps for trainee talks. Register using the link below. 👇

02.02.2026 18:58 — 👍 15    🔁 11    💬 2    📌 0

Indeed! Thanks for sharing :)

02.02.2026 07:18 — 👍 1    🔁 0    💬 0    📌 0

From sequence to function: Bridging single-molecule kinetics and molecular diversity Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...

Great to see our Science Review on emerging multiplexed single-molecule methods that use libraries to link sequence to dynamics. A fun collaborative writing project! From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science www.science.org/doi/10.1126/...

30.01.2026 18:59 — 👍 20    🔁 8    💬 2    📌 0

Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing DNA sequence regulates complex reactions and protein-DNA interactions, yet sequence effects remain poorly understood due to the lack of direct, high-throughput approaches to study sequence-dependence ...

New preprint! We share a new *DNA-only* method for single-molecule DNA sequencing, and use this cool tool to link single-molecule reactions/interactions to sequence. Big thanks🙏 to Jagadish Hazra @becs-andrews.bsky.social and all contributors since our 2016 start!
www.biorxiv.org/content/10.1...

05.12.2025 12:04 — 👍 8    🔁 2    💬 1    📌 1

Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction The bacterial SOS response unfolds in a defined temporal order, but the determinants of this hierarchy are unclear. This study shows that intrinsic promoter strength, modulated in part by sigma factor...

1/Now published! We identify a novel regulatory layer underlying SOS response dynamic. Find a short summary about our findings below.
journals.plos.org/plosbiology/...
#MicroSky

10.12.2025 13:46 — 👍 10    🔁 5    💬 1    📌 0

Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet

🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain

📝Program and registration info: meetings.embo.org/event/26-bac...

👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social

#MicroSky

20.11.2025 10:16 — 👍 41    🔁 26    💬 1    📌 0

Genome integrity relies on rapid recycling of DNA Pol III in bacteria | PNAS DNA replication requires precise coordination between DNA unwinding and DNA synthesis. In all domains of life, protein–protein interactions at the ...

Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!

20.11.2025 16:54 — 👍 37    🔁 16    💬 1    📌 2